Pathogenic Escherichia coli infection (WP2272)

Sources: [http://www.genome.jp/kegg/pathway/hsa/hsa05130.html KEGG] Escherichia coli (commonly abbreviated E. coli) is a gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms (endotherms). Most E. coli strains are harmless, but some serotypes are pathogenic and can cause serious food poisoning in humans, and are occasionally responsible for product recalls. E. coli are also responsible for a majority of cases of urinary tract infections. The harmless strains are part of the normal flora of the gut, and can benefit their hosts by producing vitamin K2, and by preventing the establishment of pathogenic bacteria within the intestine. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2272 CPTAC Assay Portal]
last edited

Authors

Nathan Salomonis , Alex Pico , Maintenance bot , Denise Slenter , Andika Tan , Kristina Hanspers , and Marvin Martens

Cited In

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Organism

Homo sapiens

Communities

Diseases

Annotations

Pathway Ontology: pathogenic Escherichia coli infection pathway

Cell Type Ontology: epithelial cell of small intestine epithelial cell of large intestine

Participants

Label Type Compact Identifier
Phosphatidylethanolamine Metabolite kegg.compound:C00350
TUBB6 GeneProduct ncbigene:84617
EspF GeneProduct uniprot:O85622
EspG GeneProduct uniprot:O85646
EspG2 GeneProduct uniprot:Q9EZE8
KRT18 GeneProduct ncbigene:3875
ARHGEF2 GeneProduct ncbigene:9181
ARPC5 GeneProduct ncbigene:10092
TUBB8 GeneProduct ncbigene:347688
OCLN GeneProduct ncbigene:4950
TUBA8 GeneProduct ncbigene:51807
EZR GeneProduct ncbigene:7430
ABL1 GeneProduct ncbigene:25
ITGB1 GeneProduct ncbigene:3688
TUBB3 GeneProduct ncbigene:10381
WASL GeneProduct ncbigene:8976
TUBB2B GeneProduct ncbigene:347733
FYN GeneProduct ncbigene:2534
CDC42 GeneProduct ncbigene:998
EspG2 GeneProduct uniprot:Q9EZE8
Eae GeneProduct uniprot:P43261
TUBB2C GeneProduct ncbigene:10383
TUBA4A GeneProduct ncbigene:7277
StxA GeneProduct uniprot:A8B1H9
TUBA3C GeneProduct ncbigene:7278
EspF GeneProduct uniprot:O85622
StxB GeneProduct uniprot:A7UQX3
TUBB4 GeneProduct ncbigene:10382
TUBA1C GeneProduct ncbigene:84790
EspFU GeneProduct uniprot:P0DJ88
EspH GeneProduct uniprot:O85629
ACTG1 GeneProduct ncbigene:71
TLR5 GeneProduct ncbigene:7100
TUBA3E GeneProduct ncbigene:112714
PRKCA GeneProduct ncbigene:5578
TUBA1A GeneProduct ncbigene:7846
YWHAZ GeneProduct ncbigene:7534
ACTB GeneProduct ncbigene:60
CLDN1 GeneProduct ncbigene:9076
LY96 GeneProduct ncbigene:23643
CTTN GeneProduct ncbigene:2017
actin-related protein 2/3 complex subunit 1B-like GeneProduct ncbigene:653888
NCL GeneProduct ncbigene:4691
WAS GeneProduct ncbigene:7454
TUBA3D GeneProduct ncbigene:113457
HCLS1 GeneProduct ncbigene:3059
ROCK1 GeneProduct ncbigene:6093
Bfp GeneProduct uniprot:Q0H044
EspFU GeneProduct uniprot:P0DJ88
Map GeneProduct uniprot:Q9R8E4
EspFU GeneProduct uniprot:P0DJ88
TUBA1B GeneProduct ncbigene:10376
ARPC1A GeneProduct ncbigene:10552
ARPC4 GeneProduct ncbigene:10093
CTNNB1 GeneProduct ncbigene:1499
ARPC3 GeneProduct ncbigene:10094
RHOA GeneProduct ncbigene:387
TUBAL3 GeneProduct ncbigene:79861
ARPC5L GeneProduct ncbigene:81873
ROCK2 GeneProduct ncbigene:9475
TUBB4Q GeneProduct ncbigene:56604
occludin-like GeneProduct ncbigene:100506658
TUBB1 GeneProduct ncbigene:81027
ARPC2 GeneProduct ncbigene:10109
CD14 GeneProduct ncbigene:929
TUBB GeneProduct ncbigene:203068
CDH1 GeneProduct ncbigene:999
Tir GeneProduct uniprot:P0DJ92
NCK1 GeneProduct ncbigene:4690
NCK2 GeneProduct ncbigene:8440
EspG GeneProduct uniprot:O85646
YWHAQ GeneProduct ncbigene:10971
TUBB2A GeneProduct ncbigene:7280
EspH GeneProduct uniprot:O85629
TLR4 GeneProduct ncbigene:7099
ARPC1B GeneProduct ncbigene:10095
Map GeneProduct uniprot:Q9R8E4
Tir GeneProduct uniprot:P0DJ92
NleH GeneProduct uniprot:D3QNI6
NleA GeneProduct uniprot:Q71HP5
TUBB6 GeneProduct ncbigene:84617
TUBB1 GeneProduct ncbigene:81027
TUBB4Q GeneProduct ncbigene:56604
TUBB8 GeneProduct ncbigene:347688
TUBB2B GeneProduct ncbigene:347733
TUBB4 GeneProduct ncbigene:10382
TUBB2C GeneProduct ncbigene:10383
TUBB GeneProduct ncbigene:203068
TUBB2A GeneProduct ncbigene:7280
TUBB3 GeneProduct ncbigene:10381

References

  1. Kaper JB, Nataro JP, Mobley HL. Pathogenic Escherichia coli. Nat Rev Microbiol. 2004 Feb;2(2):123–40. PubMed Europe PMC Scholia