RalA downstream regulated genes (WP2290)

Downstream genes of RalA signaling pathways, including the Rac-family GTPase-activating protein RLIP (also known as RLIP76 and ralA binding protein 1 (RALBP1)), CDC42(cell division cycle 42), RAC1 (ras-related C3 botulinum toxin substrate 1), RAC2, RAC3, the Y-box transcription factor ZO-1-associated nucleic acidbinding protein (ZONAB, also known as cold shock domain protein A (CSDA)), and two subunits of the exocyst complex, SEC5 (also known as exocyst complex component 2 (EXOC2)) and EXO84 (also known as EXOC8), which are involved in regulating cell proliferation, apoptosis and migration
last edited


Mkutmon, MaintBot, Ddigles, and Zari

Cited In


Homo sapiens



Pathway Ontology: Ras family mediated signaling pathway

Disease Ontology: chronic myeloid leukemia


Label Type Compact Identifier
ZONAB GeneProduct ncbigene:8531
RALBP1 GeneProduct ncbigene:10928
EXOC84 GeneProduct ncbigene:149371
RAC3 GeneProduct ncbigene:5881
NRAS GeneProduct ncbigene:4893
HRAS GeneProduct ncbigene:3265
RAC2 GeneProduct ncbigene:5880
CDC42 GeneProduct ncbigene:998
KRAS GeneProduct ncbigene:3845
SEC5 GeneProduct ncbigene:55770
RAC1 GeneProduct ncbigene:5879
RalA GeneProduct ncbigene:5898


  1. Fei J, Li Y, Zhu X, Luo X. miR-181a post-transcriptionally downregulates oncogenic RalA and contributes to growth inhibition and apoptosis in chronic myelogenous leukemia (CML). PLoS One. 2012;7(3):e32834. PubMed Europe PMC Scholia