RalA downstream regulated genes (WP2290)

Downstream genes of RalA signaling pathways, including the Rac-family GTPase-activating protein RLIP (also known as RLIP76 and ralA binding protein 1 (RALBP1)), CDC42(cell division cycle 42), RAC1 (ras-related C3 botulinum toxin substrate 1), RAC2, RAC3, the Y-box transcription factor ZO-1-associated nucleic acidbinding protein (ZONAB, also known as cold shock domain protein A (CSDA)), and two subunits of the exocyst complex, SEC5 (also known as exocyst complex component 2 (EXOC2)) and EXO84 (also known as EXOC8), which are involved in regulating cell proliferation, apoptosis and migration
last edited

Authors

Mkutmon, MaintBot, Ddigles, and Zari

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: Ras family mediated signaling pathway

Disease Ontology: chronic myeloid leukemia

Participants

Label Type Compact Identifier
ZONAB GeneProduct ncbigene:8531
RALBP1 GeneProduct ncbigene:10928
EXOC84 GeneProduct ncbigene:149371
RAC3 GeneProduct ncbigene:5881
NRAS GeneProduct ncbigene:4893
HRAS GeneProduct ncbigene:3265
RAC2 GeneProduct ncbigene:5880
CDC42 GeneProduct ncbigene:998
KRAS GeneProduct ncbigene:3845
SEC5 GeneProduct ncbigene:55770
RAC1 GeneProduct ncbigene:5879
RalA GeneProduct ncbigene:5898

References

  1. Fei J, Li Y, Zhu X, Luo X. miR-181a post-transcriptionally downregulates oncogenic RalA and contributes to growth inhibition and apoptosis in chronic myelogenous leukemia (CML). PLoS One. 2012;7(3):e32834. PubMed Europe PMC Scholia