Chemokine signaling pathway (WP2292)

Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production. Source: [ KEGG]
last edited


Thomas, MaintBot, Christine Chichester, Mkutmon, Leaguile, AlexanderPico, Jmelius, Khanspers, and AMTan

Cited In


Mus musculus



Pathway Ontology: chemokine mediated signaling pathway


Label Type Compact Identifier
Cx3cr1 GeneProduct ncbigene:13051
Leukocyte transendothelial migration Pathway kegg.genes:path:mmu04670
Arrb2 GeneProduct ncbigene:216869
Cxcl16 GeneProduct ncbigene:66102
Gngt2 GeneProduct ncbigene:14710
Gm13306 GeneProduct ncbigene:100039863
Crkl GeneProduct ncbigene:12929
Gng4 GeneProduct ncbigene:14706
Ccl22 GeneProduct ncbigene:20299
Pik3r1 GeneProduct ncbigene:18708
Vav2 GeneProduct ncbigene:22325
Foxo3 GeneProduct ncbigene:56484
Prkaca GeneProduct ncbigene:18747
Adcy2 GeneProduct ncbigene:210044
Ccl17 GeneProduct ncbigene:20295
Gsk3b GeneProduct ncbigene:56637
Gm11787 GeneProduct ensembl:ENSMUSG00000081660
Ppbp GeneProduct ncbigene:57349
Crk GeneProduct ncbigene:12928
Gng10 GeneProduct ncbigene:14700
Prkcb GeneProduct ncbigene:18751
Gnai2 GeneProduct ncbigene:14678
Rac2 GeneProduct ncbigene:19354
Ubiquitin mediated proteolysis Pathway kegg.genes:path:mmu04120
Rac1 GeneProduct ncbigene:19353
Jak2 GeneProduct ncbigene:16452
Cdc42 GeneProduct ncbigene:12540
Raf1 GeneProduct ncbigene:110157
Gm5741 GeneProduct ncbigene:436049
Prex1 GeneProduct ncbigene:277360
Calcium Metabolite kegg.compound:C00076
Ccl4 GeneProduct ncbigene:20303
Gnb5 GeneProduct ncbigene:14697
Pik3r2 GeneProduct ncbigene:18709
Phosphatidylinositol-3,4,5-trisphosphate Metabolite kegg.compound:C05981
Gng5 GeneProduct ncbigene:14707
Ccr8 GeneProduct ncbigene:12776
Ccl7 GeneProduct ncbigene:20306
D-myo-Inositol 1,4,5-trisphosphate Metabolite kegg.compound:C01245
Nfkb1 GeneProduct ncbigene:18033
Chuk GeneProduct ncbigene:12675
Cxcl11 GeneProduct ncbigene:56066
Ptk2 GeneProduct ncbigene:14083
Csk GeneProduct ncbigene:12988
Tiam1 GeneProduct ncbigene:21844
Gnb3 GeneProduct ncbigene:14695
3,5-Cyclic AMP Metabolite kegg.compound:C00575
Pik3r3 GeneProduct ncbigene:18710
Regulation of actin cytoskeleton Pathway wikipathways:WP523
Plcb4 GeneProduct ncbigene:18798
Dock2 GeneProduct ncbigene:94176
Braf GeneProduct ncbigene:109880
Ccr1l1 GeneProduct ncbigene:12770
Ccl9 GeneProduct ncbigene:20308
Cx3cl1 GeneProduct ncbigene:20312
Lyn GeneProduct ncbigene:17096
Prkacb GeneProduct ncbigene:18749
Adcy5 GeneProduct ncbigene:224129
Ccr3 GeneProduct ncbigene:12771
Xcr1 GeneProduct ncbigene:23832
Pxn GeneProduct ncbigene:19303
Shc1 GeneProduct ncbigene:20416
Ccr10 GeneProduct ncbigene:12777
Diacylglycerol Metabolite kegg.compound:C00165
Gng11 GeneProduct ncbigene:66066
Pf4 GeneProduct ncbigene:56744
Gm12844 GeneProduct ncbigene:433749
Jak3 GeneProduct ncbigene:16453
Pak1 GeneProduct ncbigene:18479
Wasl GeneProduct ncbigene:73178
Cxcl5 GeneProduct ncbigene:20311
Bcar1 GeneProduct ncbigene:12927
Gng2 GeneProduct ncbigene:14702
Rasgrp2 GeneProduct ncbigene:19395
Stat1 GeneProduct ncbigene:20846
MAPK signaling pathway Pathway wikipathways:WP493
Shc3 GeneProduct ncbigene:20418
Pik3cb GeneProduct ncbigene:74769
Ccl1 GeneProduct ncbigene:20290
Pik3cd GeneProduct ncbigene:18707
Ccr7 GeneProduct ncbigene:12775
Gsk3a GeneProduct ncbigene:606496
Ccr1 GeneProduct ncbigene:12768
Cytokine-cytokine receptor interaction Pathway kegg.genes:path:mmu04060
Adrbk1 GeneProduct ncbigene:110355
Vav1 GeneProduct ncbigene:22324
Stat2 GeneProduct ncbigene:20847
Ccl11 GeneProduct ncbigene:20292
Grk6 GeneProduct ncbigene:26385
Plcb3 GeneProduct ncbigene:18797
Cxcl9 GeneProduct ncbigene:17329
Shc2 GeneProduct ncbigene:216148
Pik3r5 GeneProduct ncbigene:320207
Cxcr6 GeneProduct ncbigene:80901
Cxcl14 GeneProduct ncbigene:57266
Ccl8 GeneProduct ncbigene:20307
Ccl12 GeneProduct ncbigene:20293
Gnai3 GeneProduct ncbigene:14679
Jak-STAT signaling pathway Pathway kegg.genes:path:mmu04630
Stat5b GeneProduct ncbigene:20851
Ccr4 GeneProduct ncbigene:12773
Shc4 GeneProduct ncbigene:271849
Gng7 GeneProduct ncbigene:14708
Cxcr4 GeneProduct ncbigene:12767
Gnb1 GeneProduct ncbigene:14688
Mapk1 GeneProduct ncbigene:26413
Prkcz GeneProduct ncbigene:18762
Gm4356 GeneProduct ncbigene:100043318
Itk GeneProduct ncbigene:16428
Grb2 GeneProduct ncbigene:14784
Pik3ca GeneProduct ncbigene:18706
Rock1 GeneProduct ncbigene:19877
Prkx GeneProduct ncbigene:19108
Rock2 GeneProduct ncbigene:19878
Ccl21c GeneProduct ncbigene:65956
Rela GeneProduct ncbigene:19697
Sos1 GeneProduct ncbigene:20662
Cxcr3 GeneProduct ncbigene:12766
Gng12 GeneProduct ncbigene:14701
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like GeneProduct ncbigene:100503710
Gng8 GeneProduct ncbigene:14709
Adcy7 GeneProduct ncbigene:11513
Rap1a GeneProduct ncbigene:109905
Kras GeneProduct ncbigene:16653
Xcl1 GeneProduct ncbigene:16963
Sos2 GeneProduct ncbigene:20663
Plcb2 GeneProduct ncbigene:18796
Akt2 GeneProduct ncbigene:11652
Ccr5 GeneProduct ncbigene:12774
Ccr2 GeneProduct ncbigene:12772
Gm15776 GeneProduct ncbigene:100043507
Cxcl12 GeneProduct ncbigene:20315
Cxcl1 GeneProduct ncbigene:14825
Ncf1 GeneProduct ncbigene:17969
Gngt1 GeneProduct ncbigene:14699
Cxcl10 GeneProduct ncbigene:15945
Ccl24 GeneProduct ncbigene:56221
Grk4 GeneProduct ncbigene:14772
Ccr6 GeneProduct ncbigene:12458
Ccl3 GeneProduct ncbigene:20302
Akt3 GeneProduct ncbigene:23797
Ccr9 GeneProduct ncbigene:12769
Plcb1 GeneProduct ncbigene:18795
Ikbkb GeneProduct ncbigene:16150
Ccl6 GeneProduct ncbigene:20305
Hras1 GeneProduct ncbigene:15461
Ccl28 GeneProduct ncbigene:56838
Pard3 GeneProduct ncbigene:93742
Tiam2 GeneProduct ncbigene:24001
Ccl2 GeneProduct ncbigene:20296
Akt1 GeneProduct ncbigene:11651
Cxcr1 GeneProduct ncbigene:227288
Cxcl15 GeneProduct ncbigene:20309
Vav3 GeneProduct ncbigene:57257
Nras GeneProduct ncbigene:18176
Fgr GeneProduct ncbigene:14191
Ptk2b GeneProduct ncbigene:19229
Gnb4 GeneProduct ncbigene:14696
Was GeneProduct ncbigene:22376
Ccl19 GeneProduct ncbigene:24047
Prkcz GeneProduct ncbigene:18762
Ccl25 GeneProduct ncbigene:20300
Mapk3 GeneProduct ncbigene:26417
Adcy3 GeneProduct ncbigene:104111
Gm2023 GeneProduct ncbigene:100039053
Grk1 GeneProduct ncbigene:24013
Adcy4 GeneProduct ncbigene:104110
Adcy8 GeneProduct ncbigene:11514
Ccl27a GeneProduct ncbigene:20301
Gm3785 GeneProduct ncbigene:100042311
Gng13 GeneProduct ncbigene:64337
Rhoa GeneProduct ncbigene:11848
Elmo1 GeneProduct ncbigene:140580
c-C motif chemokine 12-like GeneProduct ncbigene:100504977
Hck GeneProduct ncbigene:15162
Cxcl13 GeneProduct ncbigene:55985
Gnai1 GeneProduct ncbigene:14677
Nfkbia GeneProduct ncbigene:18035
Stat3 GeneProduct ncbigene:20848
Cxcr5 GeneProduct ncbigene:12145
Ccl26 GeneProduct ncbigene:541307
Adcy9 GeneProduct ncbigene:11515
Map2k1 GeneProduct ncbigene:26395
Prkcd GeneProduct ncbigene:18753
Gnb2 GeneProduct ncbigene:14693
Ccl5 GeneProduct ncbigene:20304
Nfkbib GeneProduct ncbigene:18036
Grk5 GeneProduct ncbigene:14773
Rap1b GeneProduct ncbigene:215449
Arrb1 GeneProduct ncbigene:109689
Ccl21a GeneProduct ncbigene:18829
Cxcl2 GeneProduct ncbigene:20310
Ikbkg GeneProduct ncbigene:16151
Adcy1 GeneProduct ncbigene:432530
Ccl20 GeneProduct ncbigene:20297
Gng3 GeneProduct ncbigene:14704
Cxcr2 GeneProduct ncbigene:12765
Adcy6 GeneProduct ncbigene:11512
Pik3cg GeneProduct ncbigene:30955