PPAR signaling pathway (WP2316)

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Adapted from KEGG: http://www.genome.jp/kegg/pathway/mmu/mmu03320.html
last edited

Authors

Thomas, MaintBot, Ddigles, AlexanderPico, Khanspers, DeSl, Fehrhart, and Fcastriota

Cited In

Organism

Mus musculus

Communities

Annotations

Cell Type Ontology: white fat cell cell of skeletal muscle

Pathway Ontology: peroxisome proliferator-activated receptor signaling pathway transcription factor mediated signaling pathway signaling pathway

Participants

Label Type Compact Identifier
Acaa1b GeneProduct ncbigene:235674
Ppard GeneProduct ncbigene:19015
Pparg GeneProduct ncbigene:19016
Ubc GeneProduct ncbigene:22190
Pck2 GeneProduct ncbigene:74551
Cyp4a31 GeneProduct ncbigene:666168
Cyp8b1 GeneProduct ncbigene:13124
Ucp1 GeneProduct ncbigene:22227
Slc27a1 GeneProduct ncbigene:26457
Hmgcs2 GeneProduct ncbigene:15360
Cyp4a10 GeneProduct ncbigene:13117
Rxrb GeneProduct ncbigene:20182
Aqp7 GeneProduct ncbigene:11832
Scd2 GeneProduct ncbigene:20250
Acox1 GeneProduct ncbigene:11430
Cyp4a12b GeneProduct ncbigene:13118
Adipocytokine signaling pathway GeneProduct kegg.genes:path:mmu04920
Scd3 GeneProduct ncbigene:30049
Scd4 GeneProduct ncbigene:329065
Nr1h3 GeneProduct ncbigene:22259
Rxra GeneProduct ncbigene:20181
Acsbg2 GeneProduct ncbigene:328845
Fabp1 GeneProduct ncbigene:14080
Cyp4a14 GeneProduct ncbigene:13119
Rxrg GeneProduct ncbigene:20183
Rxrb GeneProduct ncbigene:20182
Acsl6 GeneProduct ncbigene:216739
Angptl4 GeneProduct ncbigene:57875
Cyp27a1 GeneProduct ncbigene:104086
Acsl3 GeneProduct ncbigene:74205
Fabp7 GeneProduct ncbigene:12140
Acadm GeneProduct ncbigene:11364
Cpt1b GeneProduct ncbigene:12895
Cpt1c GeneProduct ncbigene:78070
Rxra GeneProduct ncbigene:20181
Cyp4a12a GeneProduct ncbigene:277753
Fabp3 GeneProduct ncbigene:14077
Cyp4a32 GeneProduct ncbigene:100040843
Fabp2 GeneProduct ncbigene:14079
Acsl4 GeneProduct ncbigene:50790
Dbi GeneProduct ncbigene:13167
Slc27a2 GeneProduct ncbigene:26458
Slc27a4 GeneProduct ncbigene:26569
Apoa2 GeneProduct ncbigene:11807
Cd36 GeneProduct ncbigene:12491
Slc27a1 GeneProduct ncbigene:26457
Fabp1 GeneProduct ncbigene:14080
Me1 GeneProduct ncbigene:17436
Adipoq GeneProduct ncbigene:11450
Apoc3 GeneProduct ncbigene:11814
Acsl5 GeneProduct ncbigene:433256
Fabp4 GeneProduct ncbigene:11770
Ppara GeneProduct ncbigene:19013
Fads2 GeneProduct ncbigene:56473
Rxrg GeneProduct ncbigene:20183
Cyp7a1 GeneProduct ncbigene:13122
Pltp GeneProduct ncbigene:18830
Gyk GeneProduct ncbigene:14933
Primary bile acid biosynthesis GeneProduct kegg.genes:path:mmu00120
Plin1 GeneProduct ncbigene:103968
Slc27a5 GeneProduct ncbigene:26459
Acox3 GeneProduct ncbigene:80911
Apoa5 GeneProduct ncbigene:66113
Acox2 GeneProduct ncbigene:93732
Pck1 GeneProduct ncbigene:18534
Cpt2 GeneProduct ncbigene:12896
Acsl1 GeneProduct ncbigene:14081
Fabp6 GeneProduct ncbigene:16204
Rxrb GeneProduct ncbigene:20182
Mmp1b GeneProduct ncbigene:83996
Olr1 GeneProduct ncbigene:108078
Slc27a4 GeneProduct ncbigene:26569
Cyp4a29-ps GeneProduct ncbigene:230639
Cd36 GeneProduct ncbigene:12491
Mmp1a GeneProduct ncbigene:83995
Slc27a6 GeneProduct ncbigene:225579
Cyp4a30b-ps GeneProduct ncbigene:435802
Acsbg1 GeneProduct ncbigene:94180
unsaturated fatty acids Metabolite chebi:27208
Scp2 GeneProduct ncbigene:20280
Scd1 GeneProduct ncbigene:20249
cytochrome P450 4A14-like GeneProduct ncbigene:640109
Lpl GeneProduct ncbigene:16956
Glycerophospholipid metabolism GeneProduct kegg.genes:path:mmu00564
Ilk GeneProduct ncbigene:16202
Apoa1 GeneProduct ncbigene:11806
Synthesis and degradation of ketone bodies Pathway wikipathways:WP543
Gk2 GeneProduct ncbigene:14626
Fabp3 GeneProduct ncbigene:14077
Fatty acid metabolism Pathway wikipathways:WP336
Rxrg GeneProduct ncbigene:20183
Cpt1a GeneProduct ncbigene:12894
Rxra GeneProduct ncbigene:20181
Sorbs1 GeneProduct ncbigene:20411
Fabp4 GeneProduct ncbigene:11770
Fabp5 GeneProduct ncbigene:16592
Ehhadh GeneProduct ncbigene:74147
Pdpk1 GeneProduct ncbigene:18607
Acadl GeneProduct ncbigene:11363
Acaa1a GeneProduct ncbigene:113868
saturated fatty acids Metabolite chebi:26607
eicosanoid Metabolite chebi:23899
Ciprofibrate Metabolite wikidata:Q3496452
NSAIDs Metabolite chebi:35475
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
unsaturated fatty acids Metabolite chebi:27208
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
unsaturated fatty acids Metabolite chebi:27208
eicosanoid Metabolite chebi:23899
NSAIDs Metabolite chebi:35475
Thiazolidine derivative Metabolite chebi:35622
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369

References

  1. Fujii H. PPARs-mediated intracellular signal transduction. Nihon Rinsho. 2005 Apr;63(4):565–71. PubMed Europe PMC Scholia