Parkin-ubiquitin proteasomal system pathway (WP2359)

This pathway describes the Parkin-Ubiquitin proteasome degradation system. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


Khanspers, MaintBot, Ddigles, AlexanderPico, Eweitz, and Fehrhart

Cited In


Homo sapiens



Pathway Ontology: ubiquitin/proteasome degradation pathway


Label Type Compact Identifier
SEPTIN5 GeneProduct ensembl:ENSG00000184702
Caspase-1 GeneProduct ncbigene:834
TUBAL3 GeneProduct ncbigene:79861
HSPA8 GeneProduct ncbigene:3312
TUBA4A GeneProduct ncbigene:7277
UBCH7 GeneProduct ncbigene:7332
PSMD8 GeneProduct ncbigene:5714
UBE2G1 GeneProduct ncbigene:7326
Proteasomal Degradation Pathway wikipathways:WP183
UBE2G2 GeneProduct ncbigene:7327
UBCH8 GeneProduct ncbigene:9246
UBE2J1 GeneProduct ncbigene:51465
TUBB8 GeneProduct ncbigene:347688
Cyclin E GeneProduct ncbigene:898
UBE1 GeneProduct ncbigene:7317
PSMD11 GeneProduct ncbigene:5717
Cullin 1 GeneProduct ncbigene:8454
UBE2J2 GeneProduct ncbigene:118424
FBXW7 GeneProduct ncbigene:55294
Parkin GeneProduct ncbigene:5071
Synphilin 1 GeneProduct ncbigene:9627
CASK GeneProduct ncbigene:8573
Caspase-8 GeneProduct ncbigene:841
CHIP GeneProduct ncbigene:10273
PAELR GeneProduct ncbigene:2861
Alpha-synuclein GeneProduct ncbigene:6622
SIAH1 GeneProduct ncbigene:6477
DORFIN GeneProduct ncbigene:25897
SIAH2 GeneProduct ncbigene:6478
TUBA3E GeneProduct ncbigene:112714
TUBA3D GeneProduct ncbigene:113457
TUBA3C GeneProduct ncbigene:7278
TUBA1C GeneProduct ncbigene:84790
TUBA1B GeneProduct ncbigene:10376
TUBA1A GeneProduct ncbigene:7846
TUBA8 GeneProduct ncbigene:51807
TUBA4B GeneProduct ensembl:ENSG00000243910
TUBB6 GeneProduct ncbigene:84617
TUBB4Q GeneProduct ncbigene:56604
TUBB4 GeneProduct ncbigene:10382
TUBB3 GeneProduct ncbigene:10381
TUBB2C GeneProduct ncbigene:10383
TUBB2B GeneProduct ncbigene:347733
TUBB2A GeneProduct ncbigene:7280
TUBB1 GeneProduct ncbigene:81027
TUBB GeneProduct ncbigene:203068
PSMD10 GeneProduct ncbigene:5716
PSMD1 GeneProduct ncbigene:5707
PSMC6 GeneProduct ncbigene:5706
PSMC5 GeneProduct ncbigene:5705
PSMC4 GeneProduct ncbigene:5704
PSMC3 GeneProduct ncbigene:5702
PSMC2 GeneProduct ncbigene:5701
PSMC1 GeneProduct ncbigene:5700
PSMD7 GeneProduct ncbigene:5713
PSMD6 GeneProduct ncbigene:9861
PSMD5 GeneProduct ncbigene:5711
PSMD4 GeneProduct ncbigene:5710
PSMD3 GeneProduct ncbigene:5709
PSMD2 GeneProduct ncbigene:5708
PSMD14 GeneProduct ncbigene:10213
PSMD13 GeneProduct ncbigene:5719
PSMD12 GeneProduct ncbigene:5718
PSMD9 GeneProduct ncbigene:5715
HSPA7 GeneProduct ensembl:ENSG00000225217
HSPA6 GeneProduct ncbigene:3310
HSPA5 GeneProduct ncbigene:3309
HSPA4 GeneProduct ncbigene:3308
HSPA2 GeneProduct ncbigene:3306
HSPA1L GeneProduct ncbigene:3305
HSPA1B GeneProduct ncbigene:3304
HSPA1A GeneProduct ncbigene:3303
HSPA14 GeneProduct ncbigene:51182
HSPA9 GeneProduct ncbigene:3313


  1. Smith SB, Dampier W, Tozeren A, Brown JR, Magid-Slav M. Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis. PLoS One. 2012;7(3):e33174. PubMed Europe PMC Scholia