Adipogenesis (WP236)

The different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from preadipocytes to adipocytes (fat cells). Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP236 CPTAC Assay Portal]
last edited

Authors

M.Patti, MaintBot, Khanspers, Nsalomonis, MartijnVanIersel, AlexanderPico, and AMTan

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: signaling pathway pertinent to development

Cell Type Ontology: preadipocyte

Participants

Label Type Compact Identifier
STAT5A GeneProduct ncbigene:6776
LPIN2 GeneProduct ncbigene:9663
DDIT3 GeneProduct ncbigene:1649
WNT5B GeneProduct ncbigene:81029
RORA GeneProduct ncbigene:6095
NR3C1 GeneProduct ncbigene:2908
FOXO1A GeneProduct ncbigene:2308
MIXL1 GeneProduct ncbigene:83881
DVL1 GeneProduct ncbigene:1855
SOCS1 GeneProduct ncbigene:8651
KLF6 GeneProduct ncbigene:1316
BMP4 GeneProduct ncbigene:652
IRS1 GeneProduct ncbigene:3667
OSM GeneProduct ncbigene:5008
ID3 GeneProduct ncbigene:3399
AGT GeneProduct ncbigene:183
KLF7 GeneProduct ncbigene:8609
PPARG GeneProduct ncbigene:5468
KLF15 GeneProduct ncbigene:28999
IGF1 GeneProduct ncbigene:3479
ADIPOQ GeneProduct ncbigene:9370
RARA GeneProduct ncbigene:5914
NR2F1 GeneProduct ncbigene:7025
SPOCK GeneProduct ncbigene:6695
ASIP GeneProduct ncbigene:434
WNT1 GeneProduct ncbigene:7471
INS GeneProduct ncbigene:3630
STAT2 GeneProduct ncbigene:6773
SOCS3 GeneProduct ncbigene:9021
STAT5B GeneProduct ncbigene:6777
EBF GeneProduct ncbigene:1879
CNTFR GeneProduct ncbigene:1271
FOXC2 GeneProduct ncbigene:2303
GDF10 GeneProduct ncbigene:2662
MEF2D GeneProduct ncbigene:4209
CTNNB1 GeneProduct ncbigene:1499
PTGIS GeneProduct ncbigene:5740
ADPN GeneProduct ncbigene:80339
PRLR GeneProduct ncbigene:5618
IRS2 GeneProduct ncbigene:8660
LPL GeneProduct ncbigene:4023
SFRP4 GeneProduct ncbigene:6424
ADFP GeneProduct ncbigene:123
TCF1 GeneProduct ncbigene:6927
NCOR2 GeneProduct ncbigene:9612
SP1 GeneProduct ncbigene:6667
CEBPB GeneProduct ncbigene:1051
HIF1A GeneProduct ncbigene:3091
BMP2 GeneProduct ncbigene:650
LMNA GeneProduct ncbigene:4000
NCOR1 GeneProduct ncbigene:9611
C10orf70 GeneProduct ncbigene:55847
DLK1 GeneProduct ncbigene:8788
SREBF1 GeneProduct ncbigene:6720
HMGA1 GeneProduct ncbigene:3159
PCK2 GeneProduct ncbigene:5106
GATA2 GeneProduct ncbigene:2624
MIF GeneProduct ncbigene:4282
MEF2A GeneProduct ncbigene:4205
NCOA1 GeneProduct ncbigene:8648
NRIP1 GeneProduct ncbigene:8204
EGR2 GeneProduct ncbigene:1959
RBL1 GeneProduct ncbigene:5933
AHR GeneProduct ncbigene:196
DF GeneProduct ncbigene:1675
CEBPD GeneProduct ncbigene:1052
UCP1 GeneProduct ncbigene:7350
PLIN GeneProduct ncbigene:5346
WWTR1 GeneProduct ncbigene:25937
MBNL1 GeneProduct ncbigene:4154
FZD1 GeneProduct ncbigene:8321
ZMPSTE24 GeneProduct ncbigene:10269
NDN GeneProduct ncbigene:4692
PPARA GeneProduct ncbigene:5465
TWIST1 GeneProduct ncbigene:7291
GADD45B GeneProduct ncbigene:4616
AGPAT2 GeneProduct ncbigene:10555
BSCL2 GeneProduct ncbigene:26580
GADD45A GeneProduct ncbigene:1647
PCK1 GeneProduct ncbigene:5105
PBEF1 GeneProduct ncbigene:10135
SERPINE1 GeneProduct ncbigene:5054
BMP1 GeneProduct ncbigene:649
NCOA2 GeneProduct ncbigene:10499
FAS GeneProduct ncbigene:355
E2F1 GeneProduct ncbigene:1869
TNF GeneProduct ncbigene:7124
TRIB3 GeneProduct ncbigene:57761
CEBPA GeneProduct ncbigene:1050
WNT10B GeneProduct ncbigene:7480
GATA3 GeneProduct ncbigene:2625
RBL2 GeneProduct ncbigene:5934
TGFB1 GeneProduct ncbigene:7040
STAT6 GeneProduct ncbigene:6778
LIPE GeneProduct ncbigene:3991
SMAD3 GeneProduct ncbigene:4088
SLC2A4 GeneProduct ncbigene:6517
CYP26B1 GeneProduct ncbigene:56603
NR1H3 GeneProduct ncbigene:10062
RB1 GeneProduct ncbigene:5925
GTF3A GeneProduct ncbigene:2971
RXRG GeneProduct ncbigene:6258
PPARGC1A GeneProduct ncbigene:10891
LPIN3 GeneProduct ncbigene:64900
LIF GeneProduct ncbigene:3976
EPAS1 GeneProduct ncbigene:2034
LPIN1 GeneProduct ncbigene:23175
IRS4 GeneProduct ncbigene:8471
STAT3 GeneProduct ncbigene:6774
FRZB GeneProduct ncbigene:2487
GATA4 GeneProduct ncbigene:2626
RXRA GeneProduct ncbigene:6256
LIFR GeneProduct ncbigene:3977
KLF5 GeneProduct ncbigene:688
LEP GeneProduct ncbigene:3952
PPARD GeneProduct ncbigene:5467
IL6ST GeneProduct ncbigene:3572
MEF2B GeneProduct ncbigene:4207
IRS3P GeneProduct ncbigene:442338
GH1 GeneProduct ncbigene:2688
CUGBP1 GeneProduct ncbigene:10658
BMP3 GeneProduct ncbigene:651
CYP26A1 GeneProduct ncbigene:1592
IL6 GeneProduct ncbigene:3569
CDKN1A GeneProduct ncbigene:1026
MEF2C GeneProduct ncbigene:4208
RETN GeneProduct ncbigene:56729
CREB1 GeneProduct ncbigene:1385
SCD GeneProduct ncbigene:6319
STAT1 GeneProduct ncbigene:6772
E2F4 GeneProduct ncbigene:1874

References

  1. Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol. 2000;16:145–71. PubMed Europe PMC Scholia