Histone modifications (WP2369)

Histones can undergo many post-translational modifications that are involved in transcription regulation. This pathway provides an overview of various modifications for histones H3 and H4 and the enzymes that catalyze the modifications, where known. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2369 CPTAC Assay Portal]
last edited

Authors

Egonw, Khanspers, MaintBot, AlexanderPico, Lindarieswijk, Mkutmon, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: altered transcription pathway

Participants

Label Type Compact Identifier
ASH1L GeneProduct ensembl:ENSG00000116539
H3F3A GeneProduct ensembl:ENSG00000163041
H3 Protein None
H3F3B GeneProduct ensembl:ENSG00000132475
HIST1H3D GeneProduct ensembl:ENSG00000197409
HIST1H3J GeneProduct ensembl:ENSG00000197153
HIST2H3A GeneProduct ensembl:ENSG00000203852
HIST2H3C GeneProduct ensembl:ENSG00000203811
HIST2H3D GeneProduct ensembl:ENSG00000183598
H3 Protein None
H3 Protein None
H3 Protein None
H3 Protein None
H3 Protein None
H3 Protein None
H3 Protein None
H3 Protein None
H3 Protein None
H3 Protein None
DOT1L GeneProduct ensembl:ENSG00000104885
EHMT1 GeneProduct ensembl:ENSG00000181090
EHMT2 GeneProduct ncbigene:10919
EZH1 GeneProduct ensembl:ENSG00000108799
EZH2 GeneProduct ensembl:ENSG00000106462
MLL GeneProduct ensembl:ENSG00000118058
MLL2 GeneProduct ensembl:ENSG00000167548
MLL3 GeneProduct ensembl:ENSG00000055609
MLL5 GeneProduct ensembl:ENSG00000005483
NSD1 GeneProduct ensembl:ENSG00000165671
PRDM2 GeneProduct ensembl:ENSG00000116731
SET GeneProduct ensembl:ENSG00000119335
SETBP1 GeneProduct ensembl:ENSG00000152217
SETD1A GeneProduct ensembl:ENSG00000099381
SETD1B GeneProduct ensembl:ENSG00000139718
SETD2 GeneProduct ensembl:ENSG00000181555
SETD3 GeneProduct ensembl:ENSG00000183576
SETD4 GeneProduct ensembl:ENSG00000185917
SETD5 GeneProduct ensembl:ENSG00000168137
SETD6 GeneProduct ensembl:ENSG00000103037
SETD7 GeneProduct ensembl:ENSG00000145391
SETD8 GeneProduct ensembl:ENSG00000183955
SETD9 GeneProduct ensembl:ENSG00000155542
SETDB1 GeneProduct ensembl:ENSG00000143379
SETDB2 GeneProduct ensembl:ENSG00000136169
SETMAR GeneProduct ensembl:ENSG00000170364
SMYD1 GeneProduct ensembl:ENSG00000115593
SMYD2 GeneProduct ensembl:ENSG00000143499
SMYD3 GeneProduct ensembl:ENSG00000185420
SMYD4 GeneProduct ensembl:ENSG00000186532
SMYD5 GeneProduct ensembl:ENSG00000135632
SUV39H1 GeneProduct ensembl:ENSG00000101945
SUV39H2 GeneProduct ensembl:ENSG00000152455
SUV420H1 GeneProduct ensembl:ENSG00000110066
SUV420H2 GeneProduct ensembl:ENSG00000133247
EZH1 GeneProduct ensembl:ENSG00000108799
EZH2 GeneProduct ensembl:ENSG00000106462
EED GeneProduct ensembl:ENSG00000074266
AEBP2 GeneProduct ensembl:ENSG00000139154
H4 Protein None
SUV420H1 GeneProduct ensembl:ENSG00000110066
SUV420H2 GeneProduct ensembl:ENSG00000133247
MLL GeneProduct ensembl:ENSG00000118058
MLL2 GeneProduct ensembl:ENSG00000167548
MLL3 GeneProduct ensembl:ENSG00000055609
KMT2B GeneProduct ensembl:ENSG00000272333
SETD1A GeneProduct ensembl:ENSG00000099381
SETD1B GeneProduct ensembl:ENSG00000139718
SUV39H1 GeneProduct ensembl:ENSG00000101945
SUV39H2 GeneProduct ensembl:ENSG00000152455
SETD2 GeneProduct ensembl:ENSG00000181555
H3 Protein None
H3 Protein None
H3 Protein None
H3 Protein None
H3 Protein None
H3 Protein None
H3 Protein None
H4 Protein None
H4 Protein None
H4 Protein None
H4 Protein None
H4 Protein None
HIST1H4C GeneProduct ensembl:ENSG00000197061
HIST1H4H GeneProduct ensembl:ENSG00000158406
HIST1H4I GeneProduct ensembl:ENSG00000276180
HIST1H4J GeneProduct ensembl:ENSG00000197238
HIST4H4 GeneProduct ensembl:ENSG00000197837
HIST1H3C GeneProduct ensembl:ENSG00000278272
KMT2B GeneProduct ensembl:ENSG00000272333
HIST1H3G GeneProduct ensembl:ENSG00000273983
HIST1H4K GeneProduct ensembl:ENSG00000273542
HIST1H4E GeneProduct ensembl:ENSG00000276966
HIST1H3H GeneProduct ensembl:ENSG00000278828
HIST1H4B GeneProduct ensembl:ENSG00000278705
HIST1H4L GeneProduct ensembl:ENSG00000275126
HIST1H3A GeneProduct ensembl:ENSG00000275714
HIST1H4G GeneProduct ensembl:ENSG00000275663
HIST1H3F GeneProduct ensembl:ENSG00000277775
HIST1H3B GeneProduct ensembl:ENSG00000274267
HIST1H4F GeneProduct ensembl:ENSG00000274618
HIST1H3I GeneProduct ensembl:ENSG00000275379
HIST1H4D GeneProduct ensembl:ENSG00000277157
HIST1H4A GeneProduct ensembl:ENSG00000278637
HIST1H3E GeneProduct ensembl:ENSG00000274750

References

  1. Rea S, Eisenhaber F, O’Carroll D, Strahl BD, Sun ZW, Schmid M, et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature. 2000 Aug 10;406(6796):593–9. PubMed Europe PMC Scholia
  2. Krogan NJ, Dover J, Khorrami S, Greenblatt JF, Schneider J, Johnston M, et al. COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem. 2002 Mar 29;277(13):10753–5. PubMed Europe PMC Scholia
  3. Strahl BD, Grant PA, Briggs SD, Sun Z-W, Bone JR, Caldwell JA, et al. Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol. 2002 Mar;22(5):1298–306. PubMed Europe PMC Scholia
  4. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 2002 Nov 15;16(22):2893–905. PubMed Europe PMC Scholia
  5. Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, et al. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 2004 Jun 1;18(11):1251–62. PubMed Europe PMC Scholia