Spinal cord injury (WP2431)

This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons. An example therapy is the administration of the immunosuppressant FK506, also used in transplantation to offer neuroprotection. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2431 CPTAC Assay Portal].
last edited

Authors

DMicael, MaintBot, Nsalomonis, Egonw, Ariutta, Mkutmon, Evelo, Zari, Khanspers, Lindarieswijk, DeSl, Eweitz, and Susan

Cited In

Organism

Homo sapiens

Communities

Diseases

Annotations

Cell Type Ontology: astrocyte of the spinal cord

Pathway Ontology: disease pathway neurological disorder pathway

Disease Ontology: post-traumatic stress disorder spinal cord disease

Participants

Label Type Compact Identifier
LTB4 Metabolite pubchem.compound:169
NGFR GeneProduct ensembl:ENSG00000064300
APEX1 GeneProduct ensembl:ENSG00000100823
MIF GeneProduct ensembl:ENSG00000240972
LEP GeneProduct ensembl:ENSG00000174697
LGALS3 GeneProduct ensembl:ENSG00000131981
TNFSF13 GeneProduct ensembl:ENSG00000161955
LTB4R GeneProduct ensembl:ENSG00000213903
AQP1 GeneProduct ensembl:ENSG00000240583
NO Metabolite pubchem.compound:145068
TNFSF13B GeneProduct ensembl:ENSG00000102524
AIF1 GeneProduct ncbigene:199
PTPRZ1 GeneProduct ensembl:ENSG00000106278
PDYN GeneProduct ensembl:ENSG00000101327
LTB GeneProduct ensembl:ENSG00000227507
PLXNA2 GeneProduct ensembl:ENSG00000076356
FECHP1 GeneProduct ensembl:ENSG00000235534
CSPG4 GeneProduct ensembl:ENSG00000173546
CD47 GeneProduct ensembl:ENSG00000196776
C1QB GeneProduct ensembl:ENSG00000173369
CDC42 GeneProduct ensembl:ENSG00000070831
ZFP36 GeneProduct ensembl:ENSG00000128016
FCGR2A GeneProduct ensembl:ENSG00000143226
PRB1 GeneProduct ensembl:ENSG00000251655
PTPRA GeneProduct ensembl:ENSG00000132670
IL1B GeneProduct ensembl:ENSG00000125538
ZFP36 GeneProduct ensembl:ENSG00000128016
NOS2 GeneProduct ensembl:ENSG00000007171
TNF GeneProduct ensembl:ENSG00000232810
NR4A1 GeneProduct ensembl:ENSG00000123358
IL4 GeneProduct ensembl:ENSG00000113520
BTG2 GeneProduct ensembl:ENSG00000159388
BTG2 GeneProduct ensembl:ENSG00000159388
FBR GeneProduct None
CDK2 GeneProduct ensembl:ENSG00000123374
NOS1 GeneProduct ensembl:ENSG00000089250
IL2 GeneProduct ensembl:ENSG00000109471
TNF GeneProduct ensembl:ENSG00000232810
IL6 GeneProduct ensembl:ENSG00000136244
TLR4 GeneProduct ensembl:ENSG00000136869
FOS GeneProduct ensembl:ENSG00000170345
IL1B GeneProduct ensembl:ENSG00000125538
TGFB1 GeneProduct ensembl:ENSG00000105329
TLR4 GeneProduct ensembl:ENSG00000136869
TNF GeneProduct ensembl:ENSG00000232810
EGR1 GeneProduct ensembl:ENSG00000120738
FOS GeneProduct ensembl:ENSG00000170345
MMP12 GeneProduct ensembl:ENSG00000262406
IFNG GeneProduct ensembl:ENSG00000111537
MBP GeneProduct ensembl:ENSG00000197971
RTN4 GeneProduct ensembl:ENSG00000115310
C5 GeneProduct ensembl:ENSG00000106804
CXCL1 GeneProduct ensembl:ENSG00000163739
CXCL8 GeneProduct ensembl:ENSG00000169429
AQP4 GeneProduct ensembl:ENSG00000171885
IL1B GeneProduct ensembl:ENSG00000125538
NOS2 GeneProduct ensembl:ENSG00000007171
TNF GeneProduct ensembl:ENSG00000232810
ARG1 GeneProduct ensembl:ENSG00000118520
EPHA4 GeneProduct ensembl:ENSG00000116106
EPHNB2 GeneProduct ensembl:ENSG00000125266
CXCL10 GeneProduct ensembl:ENSG00000169245
CCNG1 GeneProduct ensembl:ENSG00000113328
MMP9 GeneProduct ensembl:ENSG00000100985
NCAN GeneProduct ensembl:ENSG00000130287
SLIT1 GeneProduct ensembl:ENSG00000187122
SLIT2 GeneProduct ensembl:ENSG00000145147
SLIT3 GeneProduct ensembl:ENSG00000184347
NTN1 GeneProduct ensembl:ENSG00000065320
RGMA GeneProduct ensembl:ENSG00000182175
MMP9 GeneProduct ensembl:ENSG00000100985
MMP9 GeneProduct ensembl:ENSG00000100985
MMP9 GeneProduct ensembl:ENSG00000100985
CCR2 GeneProduct ensembl:ENSG00000121807
IL1R1 GeneProduct ensembl:ENSG00000115594
IL1A GeneProduct ncbigene:3552
CXCL1 GeneProduct ensembl:ENSG00000163739
CXCL2 GeneProduct ensembl:ENSG00000081041
CCL2 GeneProduct ensembl:ENSG00000108691
PLA2G6 GeneProduct ensembl:ENSG00000184381
PLA2G5 GeneProduct ensembl:ENSG00000127472
PLA2G2A GeneProduct ensembl:ENSG00000188257
melittin Metabolite pubchem.compound:16133648
ANXA1 GeneProduct ensembl:ENSG00000135046
ICAM1 GeneProduct ensembl:ENSG00000090339
SELP GeneProduct ensembl:ENSG00000174175
KLK8 GeneProduct ensembl:ENSG00000129455
GFAP GeneProduct ensembl:ENSG00000131095
CDK4 GeneProduct ensembl:ENSG00000135446
TACR1 GeneProduct ensembl:ENSG00000115353
E2F5 GeneProduct ensembl:ENSG00000133740
RB1 GeneProduct ensembl:ENSG00000139687
PRKCA GeneProduct ensembl:ENSG00000154229
E2F1 GeneProduct ensembl:ENSG00000101412
MAPK1 GeneProduct ensembl:ENSG00000100030
CCND1 GeneProduct ensembl:ENSG00000110092
MYC GeneProduct ensembl:ENSG00000136997
GADD45A GeneProduct ensembl:ENSG00000116717
MAPK3 GeneProduct ensembl:ENSG00000102882
TP53 GeneProduct ensembl:ENSG00000141510
CHST11 GeneProduct ensembl:ENSG00000171310
VCAN GeneProduct ensembl:ENSG00000038427
COL4A1 GeneProduct ensembl:ENSG00000187498
XYLT1 GeneProduct ensembl:ENSG00000103489
COL2A1 GeneProduct ensembl:ENSG00000139219
ACAN GeneProduct ensembl:ENSG00000157766
BCAN GeneProduct ensembl:ENSG00000132692
SOX9 GeneProduct ensembl:ENSG00000125398
TP53 GeneProduct ensembl:ENSG00000141510
GRIN1 GeneProduct ensembl:ENSG00000176884
VIM GeneProduct ensembl:ENSG00000026025
FK506 Metabolite cas:104987-11-3
PPP3CA GeneProduct ensembl:ENSG00000138814
FK506 Metabolite cas:104987-11-3
FK506 Metabolite cas:104987-11-3
GAP43 GeneProduct ensembl:ENSG00000172020
FK506 Metabolite cas:104987-11-3
FKBP1A GeneProduct ensembl:ENSG00000088832
IL2 GeneProduct ensembl:ENSG00000109471
MAG GeneProduct ensembl:ENSG00000105695
RTN4 GeneProduct ensembl:ENSG00000115310
RHOA GeneProduct ensembl:ENSG00000067560
RHOC GeneProduct ensembl:ENSG00000155366
RHOB GeneProduct ensembl:ENSG00000143878
ROCK2 GeneProduct ensembl:ENSG00000134318
OMG GeneProduct ensembl:ENSG00000126861
RTN4R GeneProduct ensembl:ENSG00000040608
LILRB3 GeneProduct ensembl:ENSG00000204577
Arachidonic acid Metabolite hmdb:HMDB0001043
PGH2 Metabolite hmdb:HMDB0001381
PTGS2 GeneProduct ncbigene:5743
ROS GeneProduct ncbigene:6098
NOX4 GeneProduct ensembl:ENSG00000086991
MIR23B Rna ensembl:ENSG00000207563
Olomoucine Metabolite hmdb:HMDB0035233
CDK1 GeneProduct ensembl:ENSG00000170312
GDNF GeneProduct ensembl:ENSG00000168621
SEMA6A GeneProduct ensembl:ENSG00000092421
GJA1 GeneProduct ensembl:ENSG00000152661
BDNF GeneProduct ensembl:ENSG00000176697
2-Methoxyestradiol Metabolite pubchem.compound:66414
RAC1 GeneProduct ensembl:ENSG00000136238
FOXO3 GeneProduct ensembl:ENSG00000118689
CDKN1B GeneProduct ensembl:ENSG00000111276
EGFR GeneProduct ensembl:ENSG00000146648
PD 168393 Metabolite pubchem.compound:4708
CASP3 GeneProduct ensembl:ENSG00000164305

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