Dopamine metabolism (WP2436)

Dopamine is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body. It is an amine synthesized by removing a carboxyl group from a molecule of its precursor chemical L-DOPA, which is synthesized in the brain and kidneys. Dopamine is also synthesized in plants and most animals. The dopamine system plays a central role in several significant medical conditions, including Parkinson's disease. Parkinson's disease is an age-related disorder characterized by movement disorders such as stiffness of the body, slowing of movement, and trembling of limbs when they are not in use. The main symptoms are caused by the loss of dopamine-secreting cells in the substantia nigra. These dopamine cells are especially vulnerable to damage, and a variety of insults, including encephalitis (as depicted in the book and movie "Awakenings"), repeated sports-related concussions, and some forms of chemical poisoning such as MPTP, can lead to substantial cell loss, producing a parkinsonian syndrome that is similar in its main features to Parkinson's disease. The most widely used treatment for parkinsonism is administration of L-DOPA, the metabolic precursor for dopamine. L-DOPA is converted to dopamine in the brain and various parts of the body by the enzyme DOPA decarboxylase. L-DOPA is used rather than dopamine itself because, unlike dopamine, it is capable of crossing the blood-brain barrier. Description source: [https://en.wikipedia.org/wiki/Dopamine Wikipedia] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2436 CPTAC Assay Portal]
last edited

Authors

Mostaszewski, MaintBot, Egonw, DeSl, Marvin M2, Mkutmon, AMTan, and Khanspers

Cited In

Organism

Homo sapiens

Communities

Annotations

Cell Type Ontology: dopaminergic neuron

Pathway Ontology: dopamine metabolic pathway classic metabolic pathway dopamine degradation pathway dopamine signaling pathway dopamine biosynthetic pathway

Participants

Label Type Compact Identifier
TYR GeneProduct ncbigene:7299
iron(2+) Metabolite chebi:29033
FAD Metabolite hmdb:HMDB0001248
Dopamine Metabolite hmdb:HMDB0000073
Dopamine semiquinone Metabolite None
SOD1 GeneProduct ncbigene:6647
Dopamine quinone Metabolite hmdb:HMDB0012219
Glutathione Metabolite hmdb:HMDB0000125
5-glutathionyl dopamine Metabolite None
L-Dopa Metabolite hmdb:HMDB0000181
CO2 Metabolite hmdb:HMDB0001967
DDC GeneProduct ncbigene:1644
DDC GeneProduct ncbigene:1644
Leukoaminochrome Metabolite hmdb:HMDB0012992
Dopaminochrome Metabolite pubchem.compound:170262
NQO1 GeneProduct ncbigene:1728
L-Dopa quinone Metabolite chebi:16852
Leucodopachrome Metabolite hmdb:HMDB0004067
L-Dopachrome Metabolite hmdb:HMDB0001430
5,6-Dihydroxyindole Metabolite hmdb:HMDB0004058
DHICA Metabolite hmdb:HMDB0001253
ICQA Metabolite pubchem.compound:46173450
Neuromelanin Metabolite wikidata:Q1981297
L-Tyrosine Metabolite hmdb:HMDB0000158
Tetrahydrobiopterin Metabolite hmdb:HMDB0000027
4a-Hydroxytetrahydrobiopterin Metabolite hmdb:HMDB0002281
TH GeneProduct ncbigene:7054
PRKACA GeneProduct ncbigene:5566
PRKACB GeneProduct ncbigene:5567
PRKACG GeneProduct ncbigene:5568
PPP2CA GeneProduct ncbigene:5515
PPP2CB GeneProduct ncbigene:5516
DOPAL Metabolite hmdb:HMDB0003791
3-Methoxytyramine Metabolite hmdb:HMDB0000022
ROS Metabolite chebi:26523
S-Adenosylhomocysteine Metabolite hmdb:HMDB0000939
1-chloro-2,4-dinitrobenzene Metabolite chebi:34718
S-Adenosylmethionine Metabolite hmdb:HMDB0001185
N-Methylserotonin Metabolite hmdb:HMDB0004369
H2O Metabolite hmdb:HMDB0002111
O2 Metabolite hmdb:HMDB0001377
H2O2 Metabolite hmdb:HMDB0003125
Ammonia Metabolite hmdb:HMDB0000051
MAOA GeneProduct ncbigene:4128
COMT GeneProduct ncbigene:1312
FAD Metabolite hmdb:HMDB0001248
MAOB GeneProduct ncbigene:4129
Homovanillin Metabolite hmdb:HMDB0005175
DOPET Metabolite hmdb:HMDB0005784
DOPAC Metabolite chebi:41941
Homovanillic acid Metabolite hmdb:HMDB0000118

References

  1. Jones DR, Moussaud S, McLean P. Targeting heat shock proteins to modulate α-synuclein toxicity. Ther Adv Neurol Disord. 2014 Jan;7(1):33–51. PubMed Europe PMC Scholia