Retinoblastoma gene in cancer (WP2446)

Describes the role of retinoblastoma (RB) gene in cancer. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2446 CPTAC Assay Portal]
last edited

Authors

JYoungren, MaintBot, Mkutmon, Egonw, Evelo, Khanspers, Lindarieswijk, AlexanderPico, Fehrhart, Finterly, and Eweitz

Cited In

Organism

Homo sapiens

Communities

CPTAC Diseases

Annotations

Pathway Ontology: disease pathway cancer pathway

Disease Ontology: cancer

Participants

Label Type Compact Identifier
ORC1 GeneProduct ncbigene:4998
RAF1 GeneProduct ncbigene:5894
FAF1 GeneProduct ncbigene:11124
MCM7 GeneProduct ncbigene:4176
RPA1 GeneProduct ncbigene:6117
CCNB2 GeneProduct ncbigene:9133
CDC45 GeneProduct ncbigene:8318
mitotic cell cycle Pathway wikipathways:WP179
SMC2 GeneProduct ncbigene:10592
PLK4 GeneProduct ncbigene:10733
MCM7 GeneProduct ncbigene:4176
ANLN GeneProduct ncbigene:54443
NPAT GeneProduct ncbigene:4863
RRM2 GeneProduct ncbigene:6241
MCM3 GeneProduct ncbigene:4172
TYMS GeneProduct ncbigene:7298
POLA1 GeneProduct ncbigene:5422
M/G1 transition of mitotic cell cycle Pathway None
MDM2 GeneProduct ncbigene:4193
CDT1 GeneProduct ncbigene:81620
G1/S transition of mitotic cell cycle Pathway wikipathways:WP45
DNA replication checkpoint Pathway None
MSH6 GeneProduct ncbigene:2956
cell cycle checkpoint Pathway None
HMGB1 GeneProduct ncbigene:3146
growth factor activity Pathway None
CDK1 GeneProduct ncbigene:983
SUV39H1 GeneProduct ncbigene:6839
KIF4A GeneProduct ncbigene:24137
RFC5 GeneProduct ncbigene:5985
MIR29B2 GeneProduct ensembl:ENSG00000284203
DNA replication Pathway wikipathways:WP466
RFC4 GeneProduct ncbigene:5984
MIR29B1 GeneProduct ensembl:ENSG00000283797
CCNE2 GeneProduct ncbigene:9134
E2F1 GeneProduct ncbigene:1869
SAP30 GeneProduct ncbigene:8819
CCDC6 GeneProduct ncbigene:8030
MCM6 GeneProduct ncbigene:4175
RABIF GeneProduct ncbigene:5877
regulation of cyclin-dependent protein kinase activity Pathway None
DNA repair Pathway wikipathways:WP1805
BARD1 GeneProduct ncbigene:580
POLD3 GeneProduct ncbigene:10714
CDK4 GeneProduct ncbigene:1019
MCM4 GeneProduct ncbigene:4173
PRIM1 GeneProduct ncbigene:5557
CDK2 GeneProduct ncbigene:1017
MIR21 Rna ensembl:ENSG00000284190
POLE GeneProduct ncbigene:5426
CCND3 GeneProduct ncbigene:896
CDC25A GeneProduct ncbigene:993
PRMT2 GeneProduct ncbigene:3275
CDC25B GeneProduct ncbigene:994
G1/S transition of mitotic cell cycle Pathway wikipathways:WP45
CDKN1A GeneProduct ncbigene:1026
RPA3 Protein ncbigene:6119
CCNB1 GeneProduct ncbigene:891
POLE2 GeneProduct ncbigene:5427
RBBP7 GeneProduct ncbigene:5931
CDKN1B GeneProduct ncbigene:1027
DCK GeneProduct ncbigene:1633
MAP kinase activity Pathway wikipathways:WP382
SMARCA2 GeneProduct ncbigene:6595
TOP2A GeneProduct ncbigene:7153
WEE1 GeneProduct ncbigene:7465
CCNE1 GeneProduct ncbigene:898
DHFR GeneProduct ncbigene:1719
SMC3 GeneProduct ncbigene:9126
SKP2 GeneProduct ncbigene:6502
ABL1 GeneProduct ncbigene:25
TFDP1 GeneProduct ncbigene:7027
G2/M transition of mitotic cell cycle Pathway wikipathways:WP1859
ABL1 GeneProduct ncbigene:25
CCND1 GeneProduct ncbigene:595
JNK cascade Pathway None
SIN3A GeneProduct ncbigene:25942
MAPK13 GeneProduct ncbigene:5603
DNMT1 GeneProduct ncbigene:1786
CCNE1 GeneProduct ncbigene:898
H2AFZ GeneProduct ncbigene:3015
TTK GeneProduct ncbigene:7272
histone H3-K9 methylation Pathway None
SMC1A GeneProduct ncbigene:8243
RPA2 Protein ncbigene:6118
CHEK1 GeneProduct ncbigene:1111
RPA1 Protein ncbigene:6117
RBP1 GeneProduct ncbigene:5947
RB1 GeneProduct ncbigene:5925
CDK1 GeneProduct ncbigene:983
HMGB2 GeneProduct ncbigene:3148
TP53 GeneProduct ncbigene:7157
CDC7 GeneProduct ncbigene:8317
PRKDC GeneProduct ncbigene:5591
HDAC1 GeneProduct ncbigene:3065
HLTF GeneProduct ncbigene:6596
MYC GeneProduct ncbigene:4609
CDKN1B GeneProduct ncbigene:1027
FANCG GeneProduct ncbigene:2189
DNA damage response, signal transduction resulting in induction of apoptosis Pathway wikipathways:WP707
RBBP4 GeneProduct ncbigene:5928
PCNA GeneProduct ncbigene:5111
CCNA2 GeneProduct ncbigene:890
STMN1 GeneProduct ncbigene:3925
RRM1 GeneProduct ncbigene:6240
RFC3 GeneProduct ncbigene:5983
RB1 GeneProduct ncbigene:5925
RB1 GeneProduct ncbigene:5925
TFDP1 GeneProduct ncbigene:7027
E2F1 GeneProduct ncbigene:1869
RB1 GeneProduct ncbigene:5925
SKP2 GeneProduct ncbigene:6502
RB1 GeneProduct ncbigene:5925
TFDP1 GeneProduct ncbigene:7027
E2F2 GeneProduct ncbigene:1870
ZNF655 Protein ncbigene:79027
RB1 GeneProduct ncbigene:5925
RB1 GeneProduct ncbigene:5925
MDM2 GeneProduct ncbigene:4193
TFDP1 GeneProduct ncbigene:7027
E2F1 GeneProduct ncbigene:1869
MDM2 GeneProduct ncbigene:4193
RBP1 GeneProduct ncbigene:5947
HDAC1 GeneProduct ncbigene:3065
TFDP1 GeneProduct ncbigene:7027
E2F1 GeneProduct ncbigene:1869
RB1 GeneProduct ncbigene:5925
RB1 GeneProduct ncbigene:5925
TFDP1 GeneProduct ncbigene:7027
E2F1 GeneProduct ncbigene:1869
RB1 GeneProduct ncbigene:5925
RB1 GeneProduct ncbigene:5925
RB1 GeneProduct ncbigene:5925
TP53 GeneProduct ncbigene:7157
E2F1 GeneProduct ncbigene:1869
E2F3 GeneProduct ncbigene:1871
TFDP1 GeneProduct ncbigene:7027
G1/S transition of mitotic cell cycle Pathway wikipathways:WP45
TFDP1 GeneProduct ncbigene:7027
E2F1 GeneProduct ncbigene:1869
TFDP1 GeneProduct ncbigene:7027
E2F2 GeneProduct ncbigene:1870
TFDP1 GeneProduct ncbigene:7027
E2F3 GeneProduct ncbigene:1869
regulation of cyclin-dependent protein kinase activity Pathway None
mitotic spindle organization Pathway None
TFDP2 GeneProduct ncbigene:7029
E2F1 GeneProduct ncbigene:1869
TFDP2 GeneProduct ncbigene:7029
E2F2 GeneProduct ncbigene:1870
TFDP2 GeneProduct ncbigene:7029
E2F3 GeneProduct ncbigene:1869
RBP1 GeneProduct ncbigene:5947
HDAC1 GeneProduct ncbigene:3065
TFDP1 GeneProduct ncbigene:7027
E2F2 GeneProduct ncbigene:1870
RB1 GeneProduct ncbigene:5925
RBP1 GeneProduct ncbigene:5947
HDAC1 GeneProduct ncbigene:3065
TFDP1 GeneProduct ncbigene:7027
E2F3 GeneProduct ncbigene:1871
RB1 GeneProduct ncbigene:5925
RBP1 GeneProduct ncbigene:5947
HDAC1 GeneProduct ncbigene:3065
TFDP2 GeneProduct ncbigene:7029
E2F1 GeneProduct ncbigene:1869
RB1 GeneProduct ncbigene:5925
RBP1 GeneProduct ncbigene:5947
HDAC1 GeneProduct ncbigene:3065
TFDP2 GeneProduct ncbigene:7029
E2F2 GeneProduct ncbigene:1870
RB1 GeneProduct ncbigene:5925
RBP1 GeneProduct ncbigene:5947
HDAC1 GeneProduct ncbigene:3065
TFDP2 GeneProduct ncbigene:7029
E2F3 GeneProduct ncbigene:1871
RB1 GeneProduct ncbigene:5925
RBP1 GeneProduct ncbigene:5947
HDAC1 GeneProduct ncbigene:3065
TFDP2 GeneProduct ncbigene:7029
E2F1 GeneProduct ncbigene:1869
RB1 GeneProduct ncbigene:5925
E2F2 GeneProduct ncbigene:1870
TFDP1 GeneProduct ncbigene:7027
RB1 GeneProduct ncbigene:5925
E2F3 GeneProduct ncbigene:1871
TFDP1 GeneProduct ncbigene:7027
RB1 GeneProduct ncbigene:5925
CDK6 GeneProduct ncbigene:1021
CCND1 GeneProduct ncbigene:595

References

  1. Welch PJ, Wang JY. Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms. Mol Cell Biol. 1995 Oct;15(10):5542–51. PubMed Europe PMC Scholia
  2. Welch PJ, Wang JY. A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell. 1993 Nov 19;75(4):779–90. PubMed Europe PMC Scholia
  3. Domínguez R, Famulari A, Vila J. Leukoencephalopathy: the frontier between what is reversible and what is persistent. Rev Neurol. 1997 Dec;25(148):2074. PubMed Europe PMC Scholia
  4. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, et al. An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol Cell. 2004 Oct 8;16(1):47–58. PubMed Europe PMC Scholia
  5. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, et al. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol. 2008 Sep;28(17):5369–80. PubMed Europe PMC Scholia
  6. Garzon R, Heaphy CEA, Havelange V, Fabbri M, Volinia S, Tsao T, et al. MicroRNA 29b functions in acute myeloid leukemia. Blood. 2009 Dec 17;114(26):5331–41. PubMed Europe PMC Scholia
  7. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, et al. MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21098–103. PubMed Europe PMC Scholia