Sulindac metabolic pathway (WP2542)

Metabolism of sulindac sulfide is catalyzed by MsrA, MsrB2, and MsrB3.
last edited

Authors

Egonw, MirellaKalafati, Mkutmon, Maxvanson, DeSl, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: classic metabolic pathway xenobiotic metabolic pathway

Participants

Label Type Compact Identifier
Sulfindac sulfide Metabolite chemspider:4509492
CYP1B1 GeneProduct ensembl:ENSG00000138061
MsrB2 GeneProduct ensembl:ENSG00000148450
Sulindac-S Metabolite pubchem.compound:11245227
MsrA GeneProduct ensembl:ENSG00000175806
FMO GeneProduct interpro:IPR000960
Sulindac-R Metabolite pubchem.compound:16046677
Sulindac sulfone Metabolite chemspider:4582441
MsrB3 GeneProduct ensembl:ENSG00000174099
CYP1A2 GeneProduct ensembl:ENSG00000140505
CYP1A2 GeneProduct ensembl:ENSG00000140505

References

  1. Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H. Studies on the metabolism and biological activity of the epimers of sulindac. Drug Metab Dispos. 2011 Jun;39(6):1014–21. PubMed Europe PMC Scholia