T cell receptor and co-stimulatory signaling (WP2583)

The activation and translocation of transcription factors NFAT, AP-1 and NF-kappa-B via the co-stimulatory signaling cascade triggered by MHC peptide, B7 proteins and PD-L1. The activation of NFAT involves a Ca2+/calcineurin disruption of a massive RNA-protein complex prior to its translocation into the nucleus and ultimate transcription factor activity. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2583 CPTAC Assay Portal].
last edited

Authors

Mbrandon, Khanspers, AlexanderPico, Mkutmon, Egonw, AMTan, MaintBot, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: calcineurin signaling pathway Toll-like receptor signaling pathway nuclear factor of activated T-cells signaling pathway

Cell Type Ontology: T cell

Participants

Label Type Compact Identifier
LCK GeneProduct ncbigene:3932
ZAP70 GeneProduct Entrez Gene
PIP2 Metabolite HMDB
LAT / SLP-76 scaffold complex Protein None
PIP3 Metabolite HMDB
PLCG1 GeneProduct Entrez Gene
ITK Protein Entrez Gene
AKT1 GeneProduct Entrez Gene
PKC-a GeneProduct Entrez Gene
SHP1 GeneProduct Entrez Gene
P13K Protein None
Ca2+ Metabolite HMDB
Bcl-xL Protein None
Erk Protein None
NFKB1 GeneProduct ncbigene:4790
AP-1 Protein None
NFAT1 Protein ncbigene:4773
Ras-GAP GeneProduct ncbigene:5921
Ras-GTP Protein None
DAG Metabolite hmdb:HMDB0007223
IP3 Metabolite hmdb:HMDB0001059
Calmodulin Protein ncbigene:801
RasGRP GeneProduct ncbigene:10125
IL2 GeneProduct ncbigene:3558
Calcineurin GeneProduct ncbigene:5530
IkBa Protein uniprot:P25963
IKK complex GeneProduct eccode:2.7.11.10
PTEN Protein Entrez Gene
PDK1 GeneProduct Entrez Gene
Ras-GDP Protein None
PIP2 Metabolite HMDB
MHC peptide Complex None
B7-1/ B7-2 Complex None
B7-1/ B7-2 Complex None
PD-L1 Complex None
NFAT1 Protein Entrez Gene
CSNK1A1 GeneProduct Entrez Gene
GSK3A GeneProduct Entrez Gene
GSK3B GeneProduct Entrez Gene
DYRK1A GeneProduct Entrez Gene
DYRK2 GeneProduct Entrez Gene
NRON GeneProduct Ensembl
FYN GeneProduct Entrez Gene
TCRA GeneProduct Entrez Gene
TCRB GeneProduct Entrez Gene
CD8A GeneProduct Entrez Gene
CD8B GeneProduct Entrez Gene
CD28 GeneProduct Entrez Gene
CTLA4 GeneProduct Entrez Gene
PDCD1 GeneProduct Entrez Gene

References

  1. Srikanth S, Gwack Y. Orai1-NFAT signalling pathway triggered by T cell receptor stimulation. Mol Cells. 2013 Mar;35(3):182–94. PubMed Europe PMC Scholia
  2. Takahashi K, Yan I, Haga H, Patel T. Long noncoding RNA in liver diseases. Hepatology. 2014 Aug;60(2):744–53. PubMed Europe PMC Scholia