Aryl hydrocarbon receptor pathway (WP2586)

The Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or polycyclic aromatic hydrocarbons which are widespread environmental pollutant causing a variety of severe health effects, e.g. immunosuppression, carcinogenesis and hepatotoxicity. AhR is a member of basic helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. In the absence of ligand, the AhR can be found in the cytosol, bound to a dimer of the heat shock protein of 90 kDa (Hsp90) and the immunophilin-like protein, AIP (also known as XAP2 and ARA9). Upon ligand binding, the AHR translocates to the nucleus and binds with ARNT. The AHR/ARNT heterodimer binds to xenobiotic response elements and regulates a diverse set of genes. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


Prakamya1986, AlexanderPico, Mkutmon, MaintBot, Zari, Egonw, MirellaKalafati, DeSl, Khanspers, and Eweitz

Cited In


Homo sapiens



Pathway Ontology: regulatory pathway


Label Type Compact Identifier
KLF6 GeneProduct ncbigene:1316
VEGFA GeneProduct ncbigene:7422
CCL1 GeneProduct ncbigene:6346
NQO1 Protein ncbigene:1728
CDKN1B GeneProduct ncbigene:1027
HSP90AA1 Protein ncbigene:3320
ESR1 Protein ncbigene:2099
Unknown None
DRE region Complex None
XRE Unknown None
ARNT GeneProduct ncbigene:405
AIP GeneProduct ensembl:ENSG00000110711
TCDD Metabolite chebi:28119
Calcium channel Unknown None
CYP1A1 GeneProduct ncbigene:1543
EGFR GeneProduct ncbigene:1956
EP300 Protein ncbigene:2033
PAH Metabolite chebi:33848
pRb Protein uniprot:P06400
Proliferation and tumorigenesis Pathway None
EBNA-3 Protein ncbigene:17494212
ZAC1 Protein ncbigene:5325
RET Protein ncbigene:5979
NFE2L2 Rna ncbigene:4780
AIP GeneProduct ensembl:ENSG00000110711
AHR GeneProduct ncbigene:196
P23 GeneProduct ensembl:ENSG00000110711
AHR GeneProduct ncbigene:196
AHR GeneProduct ncbigene:196
HSP90AA1 GeneProduct ncbigene:3320
HSP90AA1 GeneProduct ncbigene:3320
MYC Protein ncbigene:4609
TATA Complex None
EGFR pathway Pathway wikipathways:WP1910
TNF GeneProduct ncbigene:7124
CDC37 GeneProduct ncbigene:11140
SRC Protein ncbigene:6714
RAF1 GeneProduct ensembl:ENSG00000132155
MAP2K1 GeneProduct ensembl:ENSG00000169032
MAPK1 Protein ncbigene:5594
PTGS2 GeneProduct ncbigene:5743
PSRC1 GeneProduct ncbigene:84722
RELA GeneProduct ncbigene:5970
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ncbigene:5970
NFKB1 GeneProduct ncbigene:4790
EP300 Protein ncbigene:2033
PSRC1 GeneProduct ncbigene:84722
Angiogenesis Pathway wikipathways:WP1539
NCOA7 Protein ncbigene:135112
NRIP1 Protein ncbigene:8204
CYP1A1 Protein ncbigene:1543
CD36 GeneProduct ncbigene:948
LPL Protein ncbigene:4023
NFE2L2 GeneProduct ncbigene:4780
FGF21 Protein ncbigene:26291
HPGDS Protein ncbigene:27306
GCLC Protein ncbigene:2729
Oxidative stress Pathway wikipathways:WP408
NRIP1 Protein ncbigene:8204
NF1 Protein ncbigene:4763
NCOA7 Protein ncbigene:135112
NCOR2 Protein ncbigene:9612
CYP1A2 GeneProduct ncbigene:1544
CYP1B1 GeneProduct ncbigene:1545
Estrogen metabolism Pathway wikipathways:WP697
CDKN1A GeneProduct ncbigene:1026
CDK2 GeneProduct ncbigene:1017
RB1 GeneProduct ncbigene:5925
E2F1 GeneProduct ncbigene:1869
Cell cycle inhibition Pathway None
Detoxification and metabolism of xenobiotics Pathway None
Cell survival Pathway None
AHRR GeneProduct ncbigene:57491
EP300 Protein ncbigene:2033
FAS / FAS-L (Apoptosis) Pathway wikipathways:WP254
NRAS GeneProduct ensembl:ENSG00000213281
HRAS GeneProduct ensembl:ENSG00000174775
KRAS GeneProduct ensembl:ENSG00000133703
TCDD Metabolite chebi:28119
PAH Metabolite chebi:33848
Cell survival Pathway None
Modulation of estrogen receptor signaling Pathway wikipathways:WP712
HSP90AA1 GeneProduct ncbigene:3320


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