Ebstein-Barr virus LMP1 signaling (WP262)

Latent membrane protein 1 (LMP1) of the Ebstein-Barr Virus (EBV) elicits its oncogenice effects through the activation of several downstream pathways suchs as Pi3K/akt, IRF4, and NFkB pathways. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP262 CPTAC Assay Portal]
last edited

Authors

Thomas, MartijnVanIersel, MaintBot, Khanspers, Christine Chichester, AlexanderPico, Zari, Mkutmon, Roelod, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: Epstein-Barr virus infection pathway oxidative phosphorylation pathway

Participants

Label Type Compact Identifier
MAP3K3 GeneProduct ensembl:ENSG00000198909
p52 GeneProduct ensembl:ENSG00000077150
JNK GeneProduct ensembl:ENSG00000107643
TNF GeneProduct ensembl:ENSG00000232810
p65 GeneProduct ensembl:ENSG00000173039
LMP1 GeneProduct ensembl:ENSG00000196923
p65 GeneProduct ensembl:ENSG00000173039
p100 GeneProduct ensembl:ENSG00000077150
I-Kappa-B GeneProduct ensembl:ENSG00000100906
IL8 GeneProduct ensembl:ENSG00000169429
p65 GeneProduct ensembl:ENSG00000173039
TRADD GeneProduct ensembl:ENSG00000102871
IFNB GeneProduct ensembl:ENSG00000171855
IKK-beta GeneProduct ensembl:ENSG00000104365
TRAF6 GeneProduct ensembl:ENSG00000175104
IKK-alpha GeneProduct ensembl:ENSG00000213341
MAP3K7 GeneProduct ensembl:ENSG00000135341
p50 GeneProduct ensembl:ENSG00000109320
IRAK1 GeneProduct ensembl:ENSG00000184216
TRAF1 GeneProduct ensembl:ENSG00000056558
p50 GeneProduct ensembl:ENSG00000109320
CCL5 GeneProduct ensembl:ENSG00000271503
NIK GeneProduct ensembl:ENSG00000006062
TAB1 GeneProduct ensembl:ENSG00000135341
p65 GeneProduct ensembl:ENSG00000173039
IKK-alpha GeneProduct ncbigene:1147
IKK-gamma GeneProduct ensembl:ENSG00000269335
p65 GeneProduct ensembl:ENSG00000173039
p50 GeneProduct ensembl:ENSG00000109320
CCL20 GeneProduct ensembl:ENSG00000115009
p38 GeneProduct ensembl:ENSG00000100030
p65 GeneProduct ensembl:ENSG00000173039
I-Kappa-B GeneProduct ensembl:ENSG00000100906
HSP90 GeneProduct ncbigene:3320
SFC complex GeneProduct None
p50/p52 GeneProduct ensembl:ENSG00000109320

References

  1. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. J Biol Chem. 2006 Mar 24;281(12):7863–72. PubMed Europe PMC Scholia
  2. Song Y-J, Jen K-Y, Soni V, Kieff E, Cahir-McFarland E. IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2689–94. PubMed Europe PMC Scholia
  3. Lee J-S, Lee J-Y, Son JW, Oh J-H, Shin D-M, Yuk J-M, et al. Expression and regulation of the CC-chemokine ligand 20 during human tuberculosis. Scand J Immunol. 2008 Jan;67(1):77–85. PubMed Europe PMC Scholia
  4. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, et al. Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. J Leukoc Biol. 2008 Mar;83(3):648–62. PubMed Europe PMC Scholia