Tryptophan metabolism (WP270)

This pathway describes the metabolism of tryptophan, an essential amino acid. This pathway was originally converted from rat to human, using ortholog information. Original pathway was created by Sebastien Burel.
last edited

Authors

L.M.Ferrante, MaintBot, Khanspers, Egonw, Ddigles, and Fehrhart

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: tryptophan metabolic pathway

Participants

Label Type Compact Identifier
4-(2-Aminophenyl)-2,4-dioxobutanoate Metabolite None
Indolelactate Metabolite chebi:17282
2-Aminomuconate Metabolite None
3-Methylindolepyruvate Metabolite None
7,8-Dihydro-7,8-dihydroxykynurenate Metabolite None
Indole-3-acetate Metabolite None
N-Methylserotonin Metabolite None
C00877 Metabolite chebi:15473
N-Methyltryptamine Metabolite None
4,8-Dihydroxyquinoline Metabolite None
4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate Metabolite chemspider:389617
Oxaloacetate Metabolite None
3-(2-Aminoethyl)-1H-indol-5-ol Metabolite None
Indolepyruvate Metabolite pubchem.compound:803
Melatonin Metabolite chebi:16796
Indole-3-acetaldehyde Metabolite None
Glucobrassicin Metabolite None
Kynurenate Metabolite chebi:58454
C00527 Metabolite None
Formylanthranilate Metabolite None
3-Hydroxy-L-kynurenine Metabolite None
5-Methoxyindoleacetate Metabolite None
3-Methyldioxyindole Metabolite None
2-Aminomuconate Metabolite None
C01144 Metabolite chebi:15453
5-Hydroxyindoleacetaldehyde Metabolite None
3-Hydroxyanthranilate Metabolite None
Indole-3-acetaldoxime Metabolite None
5-Hydroxy-N-formylkynurenine Metabolite None
Isophenoxazine Metabolite None
5-(2-Carboxyethyl)-4,6-dihydroxypicolinate Metabolite None
Indole-3-ethanol Metabolite None
6-Hydroxyindolelactate Metabolite None
Anthranilate Metabolite None
5-Hydroxykynurenamine Metabolite chebi:28715
Anthranilate Metabolite None
5-(3-Carboxy-3-oxopropenyl)-4,6-dihydroxypicolin Metabolite None
2-Formylaminobenzaldehyde Metabolite None
2-Formaminobenzoylacetate Metabolite None
4,6-Dihydroxyquinoline Metabolite chebi:28799
L-Tryptophanyl-tRNA Metabolite None
2,3-Dihydroxyindole Metabolite None
Quinolinate Metabolite chebi:29959
Cinnavalininate Metabolite None
5-Hydroxy-L-tryptophan Metabolite None
3-Hydroxykynurenamine Metabolite None
Formyl-5-hydroxykynurenamine Metabolite None
5-Hydroxyindolepyruvate Metabolite None
3-Methoxyanthranilate Metabolite None
2-Oxoglutarate Metabolite None
N-Acetylindoxyl Metabolite chebi:15363
2-Oxoadipate Metabolite None
7,8-Dihydroxykynurenate Metabolite None
Xanthurenic Metabolite None
5-Hydroxyindoleacetate Metabolite None
C00332 Metabolite chebi:15345
5-(3-Carboxy-3-oxopropyl) -4,6-dihydroxypicolinate Metabolite None
(Z)-5-Oxohex-2-enedioate Metabolite None
5-(2-Formylethyl)-4,6-dihydroxypicolinate Metabolite None
Formyl-N-acetyl-5-methoxykynurenamine Metabolite None
3-Indoleglycolaldehyde Metabolite None
8-Methoxykynurenate Metabolite None
2-Amino-3-carboxymuconate Metabolite None
6-Hydroxykynurenate Metabolite pubchem.compound:440752
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate Metabolite None
5-Hydroxyindoleacetylglycine Metabolite None
Cyp4f1 GeneProduct ncbigene:56266
Dd5 GeneProduct ncbigene:117060
4.2.1.84 GeneProduct None
Ido1 GeneProduct ncbigene:66029
Cyp2e1 GeneProduct ncbigene:25086
Rnf25 GeneProduct ncbigene:301515
Gcdh GeneProduct ncbigene:364975
Aldh9a1 GeneProduct ncbigene:64040
Prmt1 GeneProduct ncbigene:60421
Aldh2 GeneProduct ncbigene:29539
Aldh1a2 GeneProduct ncbigene:116676
Formylkynurenine Metabolite chebi:18377
2.6.1.27 GeneProduct None
4.1.1.- GeneProduct None
1.13.11.10 GeneProduct None
Cyp2d2 GeneProduct ncbigene:25053
Asmt GeneProduct ncbigene:246281
Acetyl-CoA Metabolite chebi:15351
1.14.16.- GeneProduct None
Indole Metabolite chebi:35581
1.5.1.- GeneProduct None
Cyp1a1 GeneProduct ncbigene:24296
Mdm2 GeneProduct ncbigene:314856
Ogdh GeneProduct ncbigene:360975
1.7.3.2 GeneProduct None
Maob GeneProduct ncbigene:25750
Aldh3a2 GeneProduct ncbigene:65183
Maob GeneProduct ncbigene:25750
Ddc GeneProduct ncbigene:24311
Hsd17b10 GeneProduct ncbigene:63864
Aldh9a1 GeneProduct ncbigene:64040
Cat GeneProduct ncbigene:24248
Ube3a GeneProduct ncbigene:361585
5-Methoxytryptamine Metabolite None
1.13.11.- GeneProduct None
Hadh GeneProduct ncbigene:113965
CYP3A4 GeneProduct None
Aldh3a2 GeneProduct ncbigene:65183
2.1.1.47 GeneProduct None
Ddc GeneProduct ncbigene:24311
1.13.11.23 GeneProduct None
Ddc GeneProduct ncbigene:24311
Aldh2 GeneProduct ncbigene:29539
Maob GeneProduct ncbigene:25750
1.1.1.110 GeneProduct None
1.2.3.7 GeneProduct None
Mdm2 GeneProduct ncbigene:314856
Cyp7b1 GeneProduct ncbigene:25429
Ube3a GeneProduct ncbigene:361585
Aadat GeneProduct ncbigene:29416
1.10.3.4 GeneProduct None
Acat1 GeneProduct ncbigene:25014
Ido1 GeneProduct ncbigene:66029
Aldh1a2 GeneProduct ncbigene:116676
4.1.1.43 GeneProduct None
L-Kynurenine Metabolite chebi:16946
Kynu GeneProduct ncbigene:116682
1.14.99.2 GeneProduct None
AFMID GeneProduct ncbigene:688283
Cyp1b1 GeneProduct ncbigene:25426
2.6.1.27 GeneProduct None
1.13.11.17 GeneProduct None
Aanat GeneProduct ncbigene:25120
1.2.1.32 GeneProduct None
Aox1 GeneProduct ncbigene:54349
Dhcr24 GeneProduct ncbigene:298298
3.2.1.147 GeneProduct None
4.1.99.1 GeneProduct None
5-Hydroxykynurenine Metabolite chebi:2076
Aadat GeneProduct ncbigene:29416
Acmsd GeneProduct ncbigene:171385
Ido1 GeneProduct ncbigene:66029
1.14.13.9 GeneProduct None
Tryptamine Metabolite chebi:16765
3.5.99.5 GeneProduct None
Kynu GeneProduct ncbigene:116682
Cyp1a2 GeneProduct ncbigene:24297
Cyp2c80 GeneProduct ncbigene:292330
Cyp2b15 GeneProduct ncbigene:685222
Wars GeneProduct ncbigene:314442
N-Acetylisatin Metabolite chebi:16050
CYP2A13 GeneProduct None
ALDH1A4 GeneProduct None
Inmt GeneProduct ncbigene:368066
Cyp19a1 GeneProduct ncbigene:25147
L-Tryptophan Metabolite chebi:16828
Prmt1 GeneProduct ncbigene:60421
Indole-3-acetamide Metabolite chebi:16031
1.1.1.190 GeneProduct None
Aldh1a1 GeneProduct ncbigene:24188
3.5.1.49 GeneProduct None
3.5.5.1 GeneProduct None
Cyp2j4 GeneProduct ncbigene:65210
CYPC12 GeneProduct None
3.5.1.4 GeneProduct None
Haao GeneProduct ncbigene:56823
3-Indoleacetonitrile Metabolite None
Prmt1 GeneProduct ncbigene:60421
1.3.1.18 GeneProduct None
Abp1 GeneProduct ncbigene:65029
1.4.3.2 GeneProduct None
Rnf25 GeneProduct ncbigene:301515
Maob GeneProduct ncbigene:25750
Kynu GeneProduct ncbigene:116682
Cyp2a1 GeneProduct ncbigene:24894
2-Aminophenol Metabolite chebi:18112
2.1.1.49 GeneProduct None
Mdm2 GeneProduct ncbigene:314856
1.14.16.3 GeneProduct None
Echs1 GeneProduct ncbigene:140547
Tdo2 GeneProduct ncbigene:64206
Cyp2f4 GeneProduct ncbigene:54246
Gcdh GeneProduct ncbigene:364975
Tph1 GeneProduct ncbigene:24848
6-Hydroxymelatonin Metabolite None
Aldh1a4 GeneProduct None
2.6.1.27 GeneProduct None
1.2.1.- GeneProduct None
N-Acetylserotonin Metabolite None
1.13.12.3 GeneProduct None
Aldh1a1 GeneProduct ncbigene:24188
1.13.99.3 GeneProduct None
Cyp2a2 GeneProduct ncbigene:24895
Asmt GeneProduct ncbigene:246281
3.5.1.9 GeneProduct None
1.1.1.191 GeneProduct None

References