Hair follicle development: organogenesis - part 2 of 3 (WP2839)

The hair follicle (HF) is the biological unit responsible for producing a single hair shaft. The follicles are arranged with concentric epithelial progenitor layers surrounding the dermal core, which is the dermal papilla (DP). Classically, the development of the follicle itself can be divided into three stages: [https://www.wikipathways.org/index.php/Pathway:WP2804 Induction], Organogenesis and [https://www.wikipathways.org/index.php/Pathway:WP2840 Cytodifferentiation]. Hair follicle development is a process dependent on epithelial-mesenchymal transitions orchestrated by many signaling pathways. Here we find one of three complex regulatory pathways assembled from a text mining approach portraying the development of this key mammal-specific structure.
last edited

Authors

Danieltrinunes, Egonw, MaintBot, AlexanderPico, Jmelius, Khanspers, DeSl, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Cell Type Ontology: hair follicle cell

Pathway Ontology: regulatory pathway

Participants

Label Type Compact Identifier
RUNX2 GeneProduct uniprot:Q13950
NCAM Protein uniprot:P13591
TP63 GeneProduct uniprot:Q9H3D4
FOXI3 GeneProduct uniprot:A8MTJ6
CCND1 Protein uniprot:P24385
CDH1 GeneProduct uniprot:P12830
LEF1 Protein uniprot:Q9UJU2
SNAI1 Protein uniprot:O95863
Activin A GeneProduct uniprot:P08476
FZD1 Protein uniprot:Q9UP38
NF-kB Protein uniprot:P19838
WntPathway Pathway wikipathways:WP428
EDAR Protein uniprot:Q9UNE0
EDA Protein uniprot:Q92838
EdaPathway Pathway None
ShhPathway Pathway wikipathways:WP4249
SHH Protein uniprot:Q15465
EDAR Protein uniprot:Q9UNE0
B-catenin GeneProduct uniprot:P35222
EDA Protein uniprot:Q92838
SHH Protein uniprot:Q15465
LRP5/6 Protein uniprot:O75197
BMP s Protein uniprot:P12644
PTCH Protein uniprot:Q13635
SMO Protein uniprot:Q99835
ShhPathway Pathway wikipathways:WP4249
SHH Protein uniprot:Q15465
PTCH1 Protein uniprot:Q13635
SMO Protein uniprot:Q99835
NOG Protein uniprot:Q9BZE4
PDGFRA Protein uniprot:P16234
PDGF Protein uniprot:P04085
PDGF Protein uniprot:P04085
Noggin Protein uniprot:Q9BZE4
PTCH1 Protein uniprot:Q13635
CCND1 Protein uniprot:P24385
GJB6 GeneProduct uniprot:O95452
LEF1 Protein uniprot:Q9UJU2
FGFR2 Protein uniprot:P21802
GLI2 Protein uniprot:P10070
CCND2 Protein uniprot:P30279
ITGB1 Protein uniprot:P05556
PrimaryCilia Pathway wikipathways:WP4536
Ras-MAPKPathway Pathway None
Tgf-B2Pathway Pathway None
GLI1 Protein uniprot:P08151
GLI s Protein uniprot:P08151
FGF Protein uniprot:P05230
WNT5A Protein uniprot:P41221
WNT5A Protein uniprot:P41221
MYC Protein uniprot:P01106
Laminin-511 Protein uniprot:O15230

References