Focal adhesion: PI3K-Akt-mTOR signaling pathway (WP2841)

Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. Source: KEGG http://www.genome.jp/kegg-bin/show_pathway?org_name=mmu&mapno=04151 http://www.genome.jp/kegg-bin/show_pathway?org_name=mmu&mapno=04150 http://www.genome.jp/kegg-bin/show_pathway?org_name=mmu&mapno=04152
last edited

Authors

Zgan, Khanspers, MaintBot, Egonw, Jmelius, Mkutmon, DeSl, Marvin M2, and Eweitz

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: signaling pathway phosphatidylinositol 3-kinase signaling pathway mTOR signaling pathway cell adhesion signaling pathway

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