Hematopoietic stem cell differentiation (WP2849)

Growth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off separately from erythrocytes and megakaryocytes. Adapted from an open access image attributed to ZooFari and Mikael Häggström (http://en.wikipedia.org/wiki/User:Mikael_H%C3%A4ggstr%C3%B6m/Gallery#Medical_collaborations) and augmented from literature and NHLBI Progenitor Cell Biology Consortium (PCBC) collaborators.
last edited

Authors

AlexanderPico, BeverlyTorokStorb, Nsalomonis, DanielKuppers, Nohj, Xiusim, DebFrench, Jseita, Khanspers, MaintBot, Fehrhart, Mkutmon, WRoth, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Cell Type Ontology: peripheral blood stem cell

Pathway Ontology: Interleukin mediated signaling pathway

Participants

Label Type Compact Identifier
TENX GeneProduct uniprot:P22105
RHOH GeneProduct uniprot:Q15669
NFATC2 GeneProduct ensembl:ENSG00000101096
LEF1 GeneProduct uniprot:Q9UJU2
LMO2 GeneProduct ensembl:ENSG00000135363
FOS GeneProduct ensembl:ENSG00000170345
PIM1 GeneProduct uniprot:P11309
ZNF835 GeneProduct uniprot:Q9Y2P0
CSF1 GeneProduct ensembl:ENSG00000184371
CD34 GeneProduct uniprot:P28906
GATA2 GeneProduct uniprot:P23769
FOSB GeneProduct uniprot:P53539
HMGN5 GeneProduct uniprot:P82970
IRF5 GeneProduct uniprot:Q13568
SPI1 GeneProduct ensembl:ENSG00000066336
THB GeneProduct uniprot:P10828
IKZF1 GeneProduct ensembl:ENSG00000185811
CSF3 GeneProduct ensembl:ENSG00000108342
CBFA2T3 GeneProduct ensembl:ENSG00000129993
MYB GeneProduct ensembl:ENSG00000118513
T3JAM GeneProduct uniprot:Q9Y228
NCKAP1L GeneProduct ensembl:ENSG00000123338
KLF1 GeneProduct ensembl:ENSG00000105610
VAV1 GeneProduct ensembl:ENSG00000141968
C2TA GeneProduct uniprot:P33076
TRIM29 GeneProduct ensembl:ENSG00000137699
STAT5A GeneProduct ensembl:ENSG00000126561
KCNH2 GeneProduct ensembl:ENSG00000055118
S14L2 GeneProduct uniprot:O76054
LYL1 GeneProduct ensembl:ENSG00000104903
CDH1 GeneProduct uniprot:CDH1
IL5 GeneProduct ensembl:ENSG00000113525
HES6 GeneProduct uniprot:Q96HZ4
MUC1 GeneProduct uniprot:P15941
LMO2 GeneProduct uniprot:LMO2
GATA1 GeneProduct ensembl:ENSG00000102145
RUN1T1 GeneProduct uniprot:RUN1T1
PBX1 GeneProduct uniprot:PBX1
HLF GeneProduct uniprot:HLF
PRDM5 GeneProduct uniprot:PRDM5
ZFP37 GeneProduct uniprot:ZFP37
SCF GeneProduct ensembl:ENSG00000049130
TPO GeneProduct ensembl:ENSG00000115705
IL3 GeneProduct ensembl:ENSG00000164399
EPO GeneProduct ensembl:ENSG00000130427
IL6 GeneProduct ensembl:ENSG00000136244
IL1A GeneProduct ensembl:ENSG00000115008
CSF2 GeneProduct ensembl:ENSG00000164400
IL1B GeneProduct ensembl:ENSG00000125538
SCF GeneProduct ensembl:ENSG00000049130
IL3 GeneProduct ensembl:ENSG00000164399
CSF2 GeneProduct ensembl:ENSG00000164400
CSF2 GeneProduct ensembl:ENSG00000164400
CXCR4 GeneProduct ensembl:ENSG00000121966
MXI1 GeneProduct ensembl:ENSG00000119950
RIOK3 GeneProduct ensembl:ENSG00000101782
ALK4 GeneProduct ensembl:ENSG00000135503
MIR15A GeneProduct ensembl:ENSG00000283785
MIR223 Rna ensembl:ENSG00000284567
MIR17 Rna mirbase.mature:MIMAT0000070
MIR24A Rna ensembl:ENSG00000207617
MIR155 Rna mirbase.mature:MIMAT0000165
MIR181A Rna ensembl:ENSG00000207759
MIR128A Rna ensembl:ENSG00000207654
MIR10A Rna mirbase.mature:MIMAT0000253
MIR130A Rna ensembl:ENSG00000208009
MIR16-1 GeneProduct ensembl:ENSG00000208006
MIR451 Rna mirbase.mature:MIMAT0001631
MIR221 Rna ensembl:ENSG00000207870
MIR222 Rna ensembl:ENSG00000207870
MIR150 Rna ensembl:ENSG00000207782
TPO GeneProduct ensembl:ENSG00000115705
TPO GeneProduct ensembl:ENSG00000115705
GATA1 GeneProduct ensembl:ENSG00000102145
GATA1 GeneProduct ensembl:ENSG00000102145
GATA1 GeneProduct ensembl:ENSG00000102145
ABO GeneProduct ensembl:ENSG00000175164
CD41 GeneProduct ensembl:ENSG00000005961
CD42 GeneProduct ensembl:ENSG00000169704
CD34 GeneProduct None
CD235a GeneProduct ensembl:ENSG00000170180
SPI1 GeneProduct ensembl:ENSG00000066336
RUNX1 GeneProduct ensembl:ENSG00000159216
NOTCH1 GeneProduct ensembl:ENSG00000148400
MIR223 Rna ensembl:ENSG00000284567
MIR155 Rna mirbase.mature:MIMAT0000165
MIR223 GeneProduct ensembl:ENSG00000284567
MIR155 Rna mirbase.mature:MIMAT0000165
FLI1 GeneProduct ensembl:ENSG00000151702
UM279 Metabolite None
CD41 GeneProduct ensembl:ENSG00000005961
GATA2 GeneProduct ensembl:ENSG00000179348
NFE2 GeneProduct ensembl:ENSG00000123405
CD61 GeneProduct ncbigene:3690
LOXL3 GeneProduct uniprot:LOXL3
TXK GeneProduct uniprot:TXK
GATA5 GeneProduct uniprot:GATA5
WNT11 GeneProduct uniprot:WNT11
HEXIM1 GeneProduct uniprot:HEXIM1
ZGLP1 GeneProduct uniprot:ZGLP1
EGF GeneProduct uniprot:EGF
TGFB1 GeneProduct uniprot:TGFB1
LBX2 GeneProduct uniprot:LBX2
ELF1 GeneProduct uniprot:ELF1
ZNF792 GeneProduct uniprot:ZNF792
RCAN1 GeneProduct uniprot:RCAN1
FLI1 GeneProduct uniprot:FLI1
HEXIM2 GeneProduct uniprot:HEXIM2
NLK GeneProduct uniprot:NLK
MED12L GeneProduct uniprot:MED12L
ZNF789 GeneProduct uniprot:ZNF789
F2R GeneProduct uniprot:F2R
PADI4 GeneProduct uniprot:PADI4
MEF2C GeneProduct uniprot:MEF2C
CRLF3 GeneProduct uniprot:CRLF3
PIM2 GeneProduct uniprot:PIM2
IL3 GeneProduct ensembl:ENSG00000164399
IL6 GeneProduct ensembl:ENSG00000136244
SCF GeneProduct ensembl:ENSG00000049130
CSF2 GeneProduct ensembl:ENSG00000164400
CSF3 GeneProduct ensembl:ENSG00000108342
IL3 GeneProduct ensembl:ENSG00000164399
IL6 GeneProduct ensembl:ENSG00000136244
SCF GeneProduct ensembl:ENSG00000049130
CSF2 GeneProduct ensembl:ENSG00000164400
CSF2 GeneProduct ensembl:ENSG00000164400
IL3 GeneProduct ensembl:ENSG00000164399
IL3 GeneProduct ensembl:ENSG00000164399
IL6 GeneProduct ensembl:ENSG00000136244
SCF GeneProduct ensembl:ENSG00000049130
CSF2 GeneProduct ensembl:ENSG00000164400

References

  1. Slavov SN, Gimenes Teixeira HL, Rego EM. The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis. Braz J Med Biol Res. 2010 Jul;43(7):619–26. PubMed Europe PMC Scholia
  2. Zhang L, Sankaran VG, Lodish HF. MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment. Leukemia. 2012 Nov;26(11):2310–6. PubMed Europe PMC Scholia
  3. Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, et al. Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell. 2014 Apr 24;157(3):549–64. PubMed Europe PMC Scholia