Ectoderm differentiation (WP2858)

Model depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from: https://www.synapse.org/#!Synapse:syn1773109. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2858 CPTAC Assay Portal]
last edited

Authors

Nsalomonis, Egonw, MaintBot, Zari, Khanspers, Fehrhart, Susan, Mkutmon, Marvin M2, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: regulatory pathway

Participants

Label Type Compact Identifier
TSKU GeneProduct ensembl:ENSG00000182704
SMAD4 GeneProduct ensembl:ENSG00000141646
PGM1 GeneProduct ensembl:ENSG00000079739
PLCXD3 GeneProduct ensembl:ENSG00000182836
CELSR2 GeneProduct ensembl:ENSG00000143126
PPFIBP2 GeneProduct ensembl:ENSG00000166387
FZD4 GeneProduct ensembl:ENSG00000174804
FZD8 GeneProduct ensembl:ENSG00000177283
ROR2 GeneProduct ensembl:ENSG00000169071
MIR34C GeneProduct ensembl:ENSG00000207562
ASTN1 GeneProduct ensembl:ENSG00000152092
LDB2 GeneProduct ncbigene:9079
CCL2 GeneProduct ensembl:ENSG00000108691
TNFRSF11B GeneProduct ensembl:ENSG00000164761
MIR486 Rna mirbase.mature:MIMAT0002177
BCAS3 GeneProduct ensembl:ENSG00000141376
GAS2L1 GeneProduct ensembl:ENSG00000185340
PIM1 GeneProduct ncbigene:5292
ZBTB2 GeneProduct ncbigene:57621
CLVS1 GeneProduct ensembl:ENSG00000177182
BAZ1A GeneProduct ncbigene:11177
HIST1H2BH GeneProduct ncbigene:8345
ZNF219 GeneProduct ensembl:ENSG00000165804
GRAMD1B GeneProduct ensembl:ENSG00000023171
ANKS1B GeneProduct ensembl:ENSG00000185046
FOXL1 GeneProduct ensembl:ENSG00000176678
GATA6 GeneProduct ensembl:ENSG00000141448
UBTF GeneProduct ncbigene:7343
GREB1 GeneProduct ensembl:ENSG00000196208
DMD GeneProduct ensembl:ENSG00000198947
C1GALT1 GeneProduct ensembl:ENSG00000106392
KCNK10 GeneProduct ensembl:ENSG00000100433
NLK GeneProduct ensembl:ENSG00000087095
MECP2 GeneProduct ensembl:ENSG00000169057
MYC GeneProduct ncbigene:4609
ZFHX4 GeneProduct ensembl:ENSG00000091656
ZBTB2 GeneProduct ncbigene:57621
MIR361 GeneProduct ensembl:ENSG00000199051
RRBP1 GeneProduct ensembl:ENSG00000125844
WDR44 GeneProduct ensembl:ENSG00000131725
KIFC3 GeneProduct ensembl:ENSG00000140859
PTPRB GeneProduct ensembl:ENSG00000127329
NARS2 GeneProduct ensembl:ENSG00000137513
ARHGDIG GeneProduct ensembl:ENSG00000242173
POU2F2 GeneProduct ensembl:ENSG00000028277
PODXL GeneProduct ensembl:ENSG00000128567
CLDN11 GeneProduct ensembl:ENSG00000013297
ELOVL2 GeneProduct ensembl:ENSG00000197977
SKIL GeneProduct ncbigene:6498
SORCS1 GeneProduct ensembl:ENSG00000108018
PRKAG2 GeneProduct ensembl:ENSG00000106617
PHF8 GeneProduct ensembl:ENSG00000172943
SPRY2 GeneProduct ensembl:ENSG00000136158
TRIM33 GeneProduct ensembl:ENSG00000197323
RHPN1 GeneProduct ensembl:ENSG00000158106
FZD5 GeneProduct ensembl:ENSG00000163251
PLXNA2 GeneProduct ensembl:ENSG00000076356
STC1 GeneProduct ensembl:ENSG00000159167
JAKMIP1 GeneProduct ensembl:ENSG00000152969
MYC GeneProduct ncbigene:4609
MZF1 GeneProduct ensembl:ENSG00000099326
LY6E GeneProduct ensembl:ENSG00000160932
ST8SIA4 GeneProduct ensembl:ENSG00000113532
SERPINB6 GeneProduct ensembl:ENSG00000124570
ARHGDIG GeneProduct ensembl:ENSG00000242173
AES GeneProduct ensembl:ENSG00000104964
NFATC1 GeneProduct ensembl:ENSG00000131196
ZBTB2 GeneProduct ncbigene:57621
GLB1 GeneProduct ensembl:ENSG00000170266
PI4KA GeneProduct ensembl:ENSG00000241973
EDA GeneProduct ensembl:ENSG00000158813
ARX GeneProduct ensembl:ENSG00000004848
RGMA GeneProduct ensembl:ENSG00000182175
TRPM2 GeneProduct ensembl:ENSG00000142185
MIR15B GeneProduct ensembl:ENSG00000207779
KIAA1161 GeneProduct ensembl:ENSG00000164976
STX16 GeneProduct ensembl:ENSG00000124222
CROCCP2 GeneProduct ensembl:ENSG00000215908
ELOVL4 GeneProduct ensembl:ENSG00000118402
TOX3 GeneProduct ensembl:ENSG00000103460
CAP2 GeneProduct ensembl:ENSG00000112186
SOCS2 GeneProduct ensembl:ENSG00000120833
ABCC4 GeneProduct ensembl:ENSG00000125257
SCHIP1 GeneProduct ensembl:ENSG00000151967
PPARD GeneProduct ensembl:ENSG00000112033
FOXA2 GeneProduct ensembl:ENSG00000125798
SNCA GeneProduct ensembl:ENSG00000145335
PAX6 GeneProduct ensembl:ENSG00000007372
PAX3 GeneProduct ensembl:ENSG00000135903
ARHGAP15 GeneProduct ensembl:ENSG00000075884
GLI3 GeneProduct ensembl:ENSG00000106571
SHH GeneProduct ensembl:ENSG00000164690
CTNNB1 GeneProduct ensembl:ENSG00000168036
WNT1 GeneProduct ensembl:ENSG00000125084
OGT GeneProduct ensembl:ENSG00000147162
NR2F2 GeneProduct ensembl:ENSG00000185551
BOC GeneProduct ensembl:ENSG00000144857
PAN2 GeneProduct ensembl:ENSG00000135473
CTBP1 GeneProduct ensembl:ENSG00000159692
CCDC88C GeneProduct ensembl:ENSG00000015133
HDAC10 GeneProduct ensembl:ENSG00000100429
VAX2 GeneProduct ensembl:ENSG00000116035
ARHGEF9 GeneProduct ensembl:ENSG00000131089
CTNNA2 GeneProduct ensembl:ENSG00000066032
JUP GeneProduct ensembl:ENSG00000173801
MKS1 GeneProduct ensembl:ENSG00000011143
CCDC130 GeneProduct ensembl:ENSG00000104957
SGSM3 GeneProduct ensembl:ENSG00000100359
SDCBP GeneProduct ensembl:ENSG00000137575
EDA GeneProduct ensembl:ENSG00000158813
FGFR2 GeneProduct ensembl:ENSG00000066468
KRT6A GeneProduct ensembl:ENSG00000205420
HMGB2 GeneProduct ensembl:ENSG00000164104
CTNND2 GeneProduct ensembl:ENSG00000169862
ZBTB16 GeneProduct ensembl:ENSG00000109906
CDH6 GeneProduct ensembl:ENSG00000113361
TSC22D1 GeneProduct ensembl:ENSG00000102804
CDH8 GeneProduct ensembl:ENSG00000150394
NUMA1 GeneProduct ensembl:ENSG00000137497
LHX1 GeneProduct ensembl:ENSG00000273706
TCF3 GeneProduct ensembl:ENSG00000071564
ZBTB7B GeneProduct ensembl:ENSG00000160685
TTC14 GeneProduct ensembl:ENSG00000163728
RAB8B GeneProduct ensembl:ENSG00000166128
NF2 GeneProduct ensembl:ENSG00000186575
NLK GeneProduct ensembl:ENSG00000087095
NLGN1 GeneProduct ensembl:ENSG00000169760
EDA2R GeneProduct ensembl:ENSG00000131080
PTPN13 GeneProduct ensembl:ENSG00000163629
AHI1 GeneProduct ensembl:ENSG00000135541
ZFHX4 GeneProduct ensembl:ENSG00000091656
FYN GeneProduct ensembl:ENSG00000010810
PDE7A GeneProduct ensembl:ENSG00000205268
CDON GeneProduct ensembl:ENSG00000064309
RIT1 GeneProduct ensembl:ENSG00000143622
SMURF1 GeneProduct ensembl:ENSG00000198742
TBL1X GeneProduct ensembl:ENSG00000101849
HDAC6 GeneProduct ensembl:ENSG00000094631
BMP4 GeneProduct ensembl:ENSG00000125378
BMPR1A GeneProduct ensembl:ENSG00000107779
TCF7L1 GeneProduct ensembl:ENSG00000152284
HESX1 GeneProduct ensembl:ENSG00000163666
SIX6 GeneProduct ensembl:ENSG00000184302
ARHGAP10 GeneProduct ensembl:ENSG00000071205
MAFB GeneProduct ensembl:ENSG00000204103
TFAP2C GeneProduct ensembl:ENSG00000087510
MIR124-1 Rna mirbase.mature:MIMAT0000422
SOX2 GeneProduct ensembl:ENSG00000181449
TFAP2A GeneProduct ensembl:ENSG00000137203
ZBTB2 GeneProduct ncbigene:57621
FHL2 GeneProduct ncbigene:2274
SKIL GeneProduct ncbigene:6498
BCOR GeneProduct ncbigene:54880

References

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  8. Leung AW, Kent Morest D, Li JYH. Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from human embryonic stem cells. Dev Biol. 2013 Jul 15;379(2):208–20. PubMed Europe PMC Scholia
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