Aryl hydrocarbon receptor pathway (WP2873)

The aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic metabolism, e.g. cytochrome P450 enzymes. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2873 CPTAC Assay Portal]
last edited

Authors

Riannefijten, MaintBot, Egonw, Khanspers, AlexanderPico, MirellaKalafati, DeSl, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: regulatory pathway aryl hydrocarbon receptor signaling pathway

Participants

Label Type Compact Identifier
EGFR pathway Pathway wikipathways:WP1910
EP300 GeneProduct ensembl:ENSG00000100393
HSP90AA1 GeneProduct ensembl:ENSG00000080824
Ligand Metabolite chebi:72768
SRC GeneProduct ensembl:ENSG00000197122
AIP GeneProduct ensembl:ENSG00000110711
AHR GeneProduct ensembl:ENSG00000106546
EGFR GeneProduct ensembl:ENSG00000146648
HSP90AA1 GeneProduct ensembl:ENSG00000080824
TNF GeneProduct ensembl:ENSG00000232810
ARNT GeneProduct ncbigene:405
CDC37 GeneProduct ensembl:ENSG00000105401
AHR GeneProduct ensembl:ENSG00000106546
ARNT GeneProduct ncbigene:405
AIP GeneProduct ensembl:ENSG00000110711
SRC GeneProduct ensembl:ENSG00000197122
SRC GeneProduct ensembl:ENSG00000197122
CDC37 GeneProduct ensembl:ENSG00000105401
AHR GeneProduct ensembl:ENSG00000106546
ARNT GeneProduct ncbigene:405
AHR GeneProduct ensembl:ENSG00000106546
Ligand Metabolite chebi:72768
Ligand Metabolite chebi:72768
Ligand Metabolite chebi:72768
PTGES3 GeneProduct ensembl:ENSG00000110958
PTGES3 GeneProduct ensembl:ENSG00000110958
NCOA1 GeneProduct ensembl:ENSG00000084676
UGT1A3 GeneProduct ensembl:ENSG00000243135
SLC7A5 GeneProduct ensembl:ENSG00000103257
UGT1A4 GeneProduct ensembl:ENSG00000244474
MYOF GeneProduct ensembl:ENSG00000138119
IFNG GeneProduct ensembl:ENSG00000111537
SERPINB2 GeneProduct ensembl:ENSG00000197632
TGFB1 GeneProduct ensembl:ENSG00000105329
CAP2 GeneProduct ensembl:ENSG00000112186
UGT1A9 GeneProduct ensembl:ENSG00000241119
POLK GeneProduct ensembl:ENSG00000122008
UGT1A7 GeneProduct ensembl:ENSG00000244122
IL12A GeneProduct ensembl:ENSG00000168811
CES3 GeneProduct ensembl:ENSG00000172828
IL17B GeneProduct ensembl:ENSG00000127743
IL1B GeneProduct ensembl:ENSG00000125538
JUNB GeneProduct ensembl:ENSG00000171223
IL12B GeneProduct ensembl:ENSG00000113302
MGST1 GeneProduct ensembl:ENSG00000008394
UGT1A6 GeneProduct ensembl:ENSG00000167165
AHRR GeneProduct ensembl:ENSG00000063438
CDKN1B GeneProduct ensembl:ENSG00000111276
CYP1B1 GeneProduct ensembl:ENSG00000138061
UGT1A1 GeneProduct ensembl:ENSG00000241635
ALDH3A1 GeneProduct ensembl:ENSG00000108602
GSTA2 GeneProduct ensembl:ENSG00000244067
JUND GeneProduct ensembl:ENSG00000130522
NQO1 GeneProduct ensembl:ENSG00000181019
IGFBP1 GeneProduct ensembl:ENSG00000146678
NFE2L2 GeneProduct ensembl:ENSG00000116044
BAX GeneProduct ensembl:ENSG00000087088
JUN GeneProduct ensembl:ENSG00000177606
CYP1A2 GeneProduct ensembl:ENSG00000140505
IL2 GeneProduct ensembl:ENSG00000109471
HES1 GeneProduct ensembl:ENSG00000114315
CYP1A1 GeneProduct ensembl:ENSG00000140465

References

  1. Rowlands JC, Gustafsson JA. Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol. 1997 Mar;27(2):109–34. PubMed Europe PMC Scholia
  2. Jeon MS, Esser C. The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family. J Immunol. 2000 Dec 15;165(12):6975–83. PubMed Europe PMC Scholia
  3. Mimura J, Fujii-Kuriyama Y. Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta. 2003 Feb 17;1619(3):263–8. PubMed Europe PMC Scholia
  4. Marchand A, Tomkiewicz C, Marchandeau J-P, Boitier E, Barouki R, Garlatti M. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin. Mol Pharmacol. 2005 Feb;67(2):444–52. PubMed Europe PMC Scholia
  5. Vezina CM, Walker NJ, Olson JR. Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression. Environ Health Perspect. 2004 Nov;112(16):1636–44. PubMed Europe PMC Scholia
  6. Weiss C, Faust D, Dürk H, Kolluri SK, Pelzer A, Schneider S, et al. TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway. Oncogene. 2005 Jul 21;24(31):4975–83. PubMed Europe PMC Scholia
  7. Rodríguez-Sosa M, Elizondo G, López-Durán RM, Rivera I, Gonzalez FJ, Vega L. Over-production of IFN-gamma and IL-12 in AhR-null mice. FEBS Lett. 2005 Nov 21;579(28):6403–10. PubMed Europe PMC Scholia
  8. Bock KW, Köhle C. Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions. Biochem Pharmacol. 2006 Aug 14;72(4):393–404. PubMed Europe PMC Scholia
  9. Köhle C, Bock KW. Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochem Pharmacol. 2007 Jun 15;73(12):1853–62. PubMed Europe PMC Scholia
  10. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, et al. AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines. Chem Res Toxicol. 2007 Dec;20(12):1797–810. PubMed Europe PMC Scholia
  11. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, et al. TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A. Oncogene. 2008 Apr 3;27(15):2198–207. PubMed Europe PMC Scholia
  12. Pavek P, Dvorak Z. Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues. Curr Drug Metab. 2008 Feb;9(2):129–43. PubMed Europe PMC Scholia
  13. Haarmann-Stemmann T, Bothe H, Abel J. Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways. Biochem Pharmacol. 2009 Feb 15;77(4):508–20. PubMed Europe PMC Scholia
  14. Le Vee M, Jouan E, Fardel O. Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes. Toxicol In Vitro. 2010 Sep;24(6):1775–81. PubMed Europe PMC Scholia
  15. Lindsey S, Papoutsakis ET. The aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization. Br J Haematol. 2011 Feb;152(4):469–84. PubMed Europe PMC Scholia
  16. Bock KW. From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans. Biochem Pharmacol. 2011 Jul 1;82(1):9–16. PubMed Europe PMC Scholia
  17. Fijten RRR, Jennen DGJ, van Delft JHM. Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia