Aryl hydrocarbon receptor pathway (WP2873)

The aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic metabolism, e.g. cytochrome P450 enzymes. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


Riannefijten, MaintBot, Egonw, Khanspers, AlexanderPico, MirellaKalafati, DeSl, and Eweitz

Cited In


Homo sapiens



Pathway Ontology: regulatory pathway aryl hydrocarbon receptor signaling pathway


Label Type Compact Identifier
EGFR pathway Pathway wikipathways:WP1910
EP300 GeneProduct ensembl:ENSG00000100393
HSP90AA1 GeneProduct ensembl:ENSG00000080824
Ligand Metabolite chebi:72768
SRC GeneProduct ensembl:ENSG00000197122
AIP GeneProduct ensembl:ENSG00000110711
AHR GeneProduct ensembl:ENSG00000106546
EGFR GeneProduct ensembl:ENSG00000146648
HSP90AA1 GeneProduct ensembl:ENSG00000080824
TNF GeneProduct ensembl:ENSG00000232810
ARNT GeneProduct ncbigene:405
CDC37 GeneProduct ensembl:ENSG00000105401
AHR GeneProduct ensembl:ENSG00000106546
ARNT GeneProduct ncbigene:405
AIP GeneProduct ensembl:ENSG00000110711
SRC GeneProduct ensembl:ENSG00000197122
SRC GeneProduct ensembl:ENSG00000197122
CDC37 GeneProduct ensembl:ENSG00000105401
AHR GeneProduct ensembl:ENSG00000106546
ARNT GeneProduct ncbigene:405
AHR GeneProduct ensembl:ENSG00000106546
Ligand Metabolite chebi:72768
Ligand Metabolite chebi:72768
Ligand Metabolite chebi:72768
PTGES3 GeneProduct ensembl:ENSG00000110958
PTGES3 GeneProduct ensembl:ENSG00000110958
NCOA1 GeneProduct ensembl:ENSG00000084676
UGT1A3 GeneProduct ensembl:ENSG00000243135
SLC7A5 GeneProduct ensembl:ENSG00000103257
UGT1A4 GeneProduct ensembl:ENSG00000244474
MYOF GeneProduct ensembl:ENSG00000138119
IFNG GeneProduct ensembl:ENSG00000111537
SERPINB2 GeneProduct ensembl:ENSG00000197632
TGFB1 GeneProduct ensembl:ENSG00000105329
CAP2 GeneProduct ensembl:ENSG00000112186
UGT1A9 GeneProduct ensembl:ENSG00000241119
POLK GeneProduct ensembl:ENSG00000122008
UGT1A7 GeneProduct ensembl:ENSG00000244122
IL12A GeneProduct ensembl:ENSG00000168811
CES3 GeneProduct ensembl:ENSG00000172828
IL17B GeneProduct ensembl:ENSG00000127743
IL1B GeneProduct ensembl:ENSG00000125538
JUNB GeneProduct ensembl:ENSG00000171223
IL12B GeneProduct ensembl:ENSG00000113302
MGST1 GeneProduct ensembl:ENSG00000008394
UGT1A6 GeneProduct ensembl:ENSG00000167165
AHRR GeneProduct ensembl:ENSG00000063438
CDKN1B GeneProduct ensembl:ENSG00000111276
CYP1B1 GeneProduct ensembl:ENSG00000138061
UGT1A1 GeneProduct ensembl:ENSG00000241635
ALDH3A1 GeneProduct ensembl:ENSG00000108602
GSTA2 GeneProduct ensembl:ENSG00000244067
JUND GeneProduct ensembl:ENSG00000130522
NQO1 GeneProduct ensembl:ENSG00000181019
IGFBP1 GeneProduct ensembl:ENSG00000146678
NFE2L2 GeneProduct ensembl:ENSG00000116044
BAX GeneProduct ensembl:ENSG00000087088
JUN GeneProduct ensembl:ENSG00000177606
CYP1A2 GeneProduct ensembl:ENSG00000140505
IL2 GeneProduct ensembl:ENSG00000109471
HES1 GeneProduct ensembl:ENSG00000114315
CYP1A1 GeneProduct ensembl:ENSG00000140465


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