Farnesoid X receptor pathway (WP2879)

The farnesoid X receptor (FXR, a.k.a. NR1H4) is a nuclear receptor that responds to levels of bile acids present in the body and regulates many processes related to bile acids synthesis and transport. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2879 CPTAC Assay Portal]
last edited

Authors

Riannefijten, MaintBot, Khanspers, Egonw, Fehrhart, Susan, AlexanderPico, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: bile acid signaling pathway

Participants

Label Type Compact Identifier
NR1H4 GeneProduct ncbigene:9971
FXR ligand Metabolite chebi:48705
NR1H4 GeneProduct ncbigene:9971
RXRA GeneProduct ncbigene:6256
Ligand Metabolite chebi:48705
NR1H4 GeneProduct ncbigene:9971
RXRA GeneProduct ncbigene:6256
Ligand Metabolite chebi:48705
NR1H4 GeneProduct ncbigene:9971
Ligand Metabolite chebi:48705
RXRA GeneProduct ncbigene:6256
UGT2B4 GeneProduct ncbigene:7363
SULT2A1 GeneProduct ncbigene:6822
SLC27A5 GeneProduct ncbigene:10998
SLC10A1 GeneProduct ncbigene:6554
CYP7A1 GeneProduct ncbigene:1581
NR0B2 GeneProduct ncbigene:8431
FGF19 GeneProduct ncbigene:9965
IRS2 GeneProduct ncbigene:8660
ABCB11 GeneProduct ncbigene:8647
BAAT GeneProduct ncbigene:570
CYP3A4 GeneProduct ncbigene:1576
FKBP5 GeneProduct ncbigene:2289
IP6K3 GeneProduct ncbigene:117283
ABCB4 GeneProduct ncbigene:5244
NR0B2 GeneProduct ncbigene:8431
PPARGC1A GeneProduct ncbigene:10891
SLCO2B1 GeneProduct ncbigene:11309
CYP8B1 GeneProduct ncbigene:1582

References

  1. Handschin C, Meyer UA. Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Arch Biochem Biophys. 2005 Jan 15;433(2):387–96. PubMed Europe PMC Scholia
  2. Gadaleta RM, van Mil SWC, Oldenburg B, Siersema PD, Klomp LWJ, van Erpecum KJ. Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. Biochim Biophys Acta. 2010 Jul;1801(7):683–92. PubMed Europe PMC Scholia
  3. Fijten RRR, Jennen DGJ, van Delft JHM. Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia