Estrogen receptor pathway (WP2881)

The estrogen receptor is a nuclear receptor that is activated upon ligand binding and subsequently translocates to the nuclear. There, it activates transcription of target genes involved in essential cellular processes. The ER receptor has been implicated in a multitude of diseases, most notably cancer (breast/ovarian). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2881 CPTAC Assay Portal]
last edited

Authors

Riannefijten, MaintBot, Khanspers, Fehrhart, Egonw, Susan, AlexanderPico, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: estrogen signaling pathway

Participants

Label Type Compact Identifier
Estrogen Metabolite chebi:4903
Ligand Metabolite chebi:48705
SP1 GeneProduct ensembl:ENSG00000185591
ESR1 GeneProduct ensembl:ENSG00000091831
JUN GeneProduct ensembl:ENSG00000177606
ESR1 GeneProduct ensembl:ENSG00000091831
ESR1 GeneProduct ensembl:ENSG00000091831
ESR1 GeneProduct ensembl:ENSG00000091831
ESR1 GeneProduct ensembl:ENSG00000091831
ESR1 GeneProduct ensembl:ENSG00000091831
ESR1 GeneProduct ensembl:ENSG00000091831
ESR1 GeneProduct ensembl:ENSG00000091831
PDK4 GeneProduct ensembl:ENSG00000004799
STAT3 GeneProduct ensembl:ENSG00000168610
ACOX1 GeneProduct ensembl:ENSG00000161533
GPAM GeneProduct ensembl:ENSG00000119927
PCK1 GeneProduct ensembl:ENSG00000124253
CYP1A1 GeneProduct ensembl:ENSG00000140465
PPARA GeneProduct ensembl:ENSG00000186951
CYP1A2 GeneProduct ensembl:ENSG00000140505
NR0B2 GeneProduct ensembl:ENSG00000131910
CYP1B1 GeneProduct ensembl:ENSG00000138061
Ligand Metabolite chebi:48705
Ligand Metabolite chebi:48705
Ligand Metabolite chebi:48705

References

  1. Nilsson S, Gustafsson J-Å. Estrogen receptors: therapies targeted to receptor subtypes. Clin Pharmacol Ther. 2011 Jan;89(1):44–55. PubMed Europe PMC Scholia
  2. Fijten RRR, Jennen DGJ, van Delft JHM. Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia