Nuclear receptors meta-pathway (WP2882)

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. In response, these receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors generally only happens when a ligand is present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor, which, in turn, activates the receptor, resulting in up- or down-regulation of gene expression. A unique property of nuclear receptors that differentiates them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. As a consequence, nuclear receptors play key roles in both embryonic development and adult homeostasis. As discussed below, nuclear receptors may be classified according to either mechanism or homology. [From Wikipedia, the free encyclopedia]
last edited

Authors

Riannefijten, MaintBot, Egonw, Fehrhart, Mkutmon, Elisa, Eweitz, and Susan

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: regulatory pathway transcription factor mediated signaling pathway

Participants

Label Type Compact Identifier
SLC7A11 GeneProduct ensembl:ENSG00000151012
CYP2A6 GeneProduct ensembl:ENSG00000255974
HSP90AA1 GeneProduct ensembl:ENSG00000080824
IL17B GeneProduct ensembl:ENSG00000127743
SLC26A2 GeneProduct ensembl:ENSG00000155850
NR3C1 GeneProduct ensembl:ENSG00000113580
KEAP1 GeneProduct ensembl:ENSG00000079999
CCL2 GeneProduct ensembl:ENSG00000108691
SPRY1 GeneProduct ensembl:ENSG00000164056
Bile acidneosynthesis Pathway wikipathways:WP1788
PPARD GeneProduct ensembl:ENSG00000112033
CYP2B6 GeneProduct ensembl:ENSG00000197408
SMARCA1 GeneProduct ensembl:ENSG00000102038
SDPR GeneProduct ensembl:ENSG00000168497
CYP3A4 GeneProduct ensembl:ENSG00000160868
NCOA1 GeneProduct ensembl:ENSG00000084676
Bile acid &xenobiotics transport Pathway wikipathways:WP1788
EPHA2 GeneProduct ensembl:ENSG00000142627
NR0B2 GeneProduct ensembl:ENSG00000131910
TGFB2 GeneProduct ensembl:ENSG00000092969
KTN1 GeneProduct ensembl:ENSG00000126777
NR0B2 GeneProduct ensembl:ENSG00000131910
HBEGF GeneProduct ensembl:ENSG00000113070
CES1 GeneProduct ensembl:ENSG00000198848
SRGN GeneProduct ensembl:ENSG00000122862
PTGR1 GeneProduct ensembl:ENSG00000106853
PPARGC1A GeneProduct ensembl:ENSG00000109819
PDK4 GeneProduct ensembl:ENSG00000004799
UGT1A3 GeneProduct ensembl:ENSG00000243135
ZIC2 GeneProduct ensembl:ENSG00000043355
TSC22D3 GeneProduct ensembl:ENSG00000157514
ABCB11 GeneProduct ensembl:ENSG00000073734
NCOA2 GeneProduct ensembl:ENSG00000140396
SMC1A GeneProduct ensembl:ENSG00000072501
RGS2 GeneProduct ensembl:ENSG00000116741
CBR1 GeneProduct ensembl:ENSG00000159228
CYP1A1 GeneProduct ensembl:ENSG00000140465
TGFB1 GeneProduct ensembl:ENSG00000105329
BHLHE40 GeneProduct ensembl:ENSG00000134107
ARL5B GeneProduct ensembl:ENSG00000165997
IL12A GeneProduct ensembl:ENSG00000168811
SLC2A11 GeneProduct ensembl:ENSG00000133460
GSTA2 GeneProduct ensembl:ENSG00000244067
SLC2A1 GeneProduct ensembl:ENSG00000117394
EPHA3 GeneProduct ensembl:ENSG00000044524
CYP2C9 GeneProduct ensembl:ENSG00000138109
GPR115 GeneProduct ensembl:ENSG00000153294
BAAT GeneProduct ensembl:ENSG00000136881
Transcriptionfactors Pathway wikipathways:WP1822
GPX3 GeneProduct ensembl:ENSG00000211445
UGT1A1 GeneProduct ensembl:ENSG00000241635
TNFAIP3 GeneProduct ensembl:ENSG00000118503
ALDH3A1 GeneProduct ensembl:ENSG00000108602
Phase 2metabolism Pathway wikipathways:WP702
SRC GeneProduct ensembl:ENSG00000197122
UGT1A9 GeneProduct ensembl:ENSG00000241119
B3GNT5 GeneProduct ensembl:ENSG00000176597
FGD4 GeneProduct ensembl:ENSG00000139132
ABCC3 GeneProduct ensembl:ENSG00000108846
MAFG GeneProduct ensembl:ENSG00000197063
GPR153 GeneProduct ensembl:ENSG00000158292
TGFA GeneProduct ensembl:ENSG00000163235
SLC2A6 GeneProduct ensembl:ENSG00000160326
DNAJB1 GeneProduct ensembl:ENSG00000132002
SP1 GeneProduct ensembl:ENSG00000185591
CYP3A5 GeneProduct ensembl:ENSG00000106258
CYP7A1 GeneProduct ensembl:ENSG00000167910
CYP4A11 GeneProduct ensembl:ENSG00000187048
CES3 GeneProduct ensembl:ENSG00000172828
SULT2A1 GeneProduct ensembl:ENSG00000105398
CAP2 GeneProduct ensembl:ENSG00000112186
GSTA1 GeneProduct ensembl:ENSG00000243955
UGT1A3 GeneProduct ensembl:ENSG00000243135
PTGS2 GeneProduct ensembl:ENSG00000073756
THBD GeneProduct ensembl:ENSG00000178726
CYP8B1 GeneProduct ensembl:ENSG00000180432
IL12B GeneProduct ensembl:ENSG00000113302
IFNG GeneProduct ensembl:ENSG00000111537
Transcriptionfactors Pathway wikipathways:WP1822
PPARA GeneProduct ensembl:ENSG00000186951
UGT2B7 GeneProduct ensembl:ENSG00000171234
UGT1A9 GeneProduct ensembl:ENSG00000241119
SULT2A1 GeneProduct ensembl:ENSG00000105398
CES5A GeneProduct ensembl:ENSG00000159398
PPARA GeneProduct ensembl:ENSG00000186951
CCL20 GeneProduct ensembl:ENSG00000115009
Drug and steroidmetabolism Pathway wikipathways:WP496
NAV3 GeneProduct ensembl:ENSG00000067798
EDN2 GeneProduct ensembl:ENSG00000127129
ANGPTL4 GeneProduct ensembl:ENSG00000167772
ACOX1 GeneProduct ensembl:ENSG00000161533
PDGFB GeneProduct ensembl:ENSG00000100311
ABCB1 GeneProduct ensembl:ENSG00000085563
SLCO2B1 GeneProduct ensembl:ENSG00000137491
TXN GeneProduct ensembl:ENSG00000136810
SP1 GeneProduct ensembl:ENSG00000185591
GSTA3 GeneProduct ensembl:ENSG00000174156
IP6K3 GeneProduct ensembl:ENSG00000161896
SEC14L1 GeneProduct ensembl:ENSG00000129657
SLC7A5 GeneProduct ensembl:ENSG00000103257
UGT1A3 GeneProduct ensembl:ENSG00000243135
NFE2L2 GeneProduct ensembl:ENSG00000116044
HSPA1A GeneProduct ensembl:ENSG00000204389
CYP2A6 GeneProduct ensembl:ENSG00000255974
ABCG5 GeneProduct ensembl:ENSG00000138075
IRS2 GeneProduct ensembl:ENSG00000185950
SOD3 GeneProduct ensembl:ENSG00000109610
POU5F1 GeneProduct ensembl:ENSG00000204531
NR0B2 GeneProduct ensembl:ENSG00000131910
ABCB4 GeneProduct ensembl:ENSG00000005471
SLC2A10 GeneProduct ensembl:ENSG00000197496
IL11 GeneProduct ensembl:ENSG00000095752
DNAJC7 GeneProduct ensembl:ENSG00000168259
CYP1B1 GeneProduct ensembl:ENSG00000138061
NFKB2 GeneProduct ensembl:ENSG00000077150
MGST3 GeneProduct ensembl:ENSG00000143198
TXNRD3 GeneProduct ensembl:ENSG00000197763
GSR GeneProduct ensembl:ENSG00000104687
NR1H4 GeneProduct ensembl:ENSG00000012504
SLC19A2 GeneProduct ensembl:ENSG00000117479
IL1B GeneProduct ensembl:ENSG00000125538
FKBP5 GeneProduct ensembl:ENSG00000096060
NCOA6 GeneProduct ensembl:ENSG00000198646
CYP1A2 GeneProduct ensembl:ENSG00000140505
MGST2 GeneProduct ensembl:ENSG00000085871
MGAM GeneProduct ensembl:ENSG00000179087
MAFF GeneProduct ensembl:ENSG00000185022
GSTT2 GeneProduct ensembl:ENSG00000099984
FTL GeneProduct ensembl:ENSG00000087086
LRRC8A GeneProduct ensembl:ENSG00000136802
TGFB1 GeneProduct ensembl:ENSG00000105329
SRXN1 GeneProduct ensembl:ENSG00000271303
EPB41L4B GeneProduct ensembl:ENSG00000095203
CDC42EP3 GeneProduct ensembl:ENSG00000163171
BIRC3 GeneProduct ensembl:ENSG00000023445
SERTAD2 GeneProduct ensembl:ENSG00000179833
HGF GeneProduct ensembl:ENSG00000019991
CYP7A1 GeneProduct ensembl:ENSG00000167910
GSTA4 GeneProduct ensembl:ENSG00000170899
SLC10A1 GeneProduct ensembl:ENSG00000100652
GPX2 GeneProduct ensembl:ENSG00000176153
MT1IP GeneProduct ncbigene:644314
ABCC2 GeneProduct ensembl:ENSG00000023839
Cell proliferationand differentiation Pathway wikipathways:WP2029
GPAM GeneProduct ensembl:ENSG00000119927
UGT1A4 GeneProduct ensembl:ENSG00000244474
SULT1A1 GeneProduct ensembl:ENSG00000196502
DNAJC15 GeneProduct ensembl:ENSG00000120675
JUN GeneProduct ensembl:ENSG00000177606
SLC2A9 GeneProduct ensembl:ENSG00000109667
EGR1 GeneProduct ensembl:ENSG00000120738
S100P GeneProduct ensembl:ENSG00000163993
ETNK2 GeneProduct ensembl:ENSG00000143845
GADD45B GeneProduct ensembl:ENSG00000099860
ABCC3 GeneProduct ensembl:ENSG00000108846
SNAI2 GeneProduct ensembl:ENSG00000019549
CPEB4 GeneProduct ensembl:ENSG00000113742
SERPINA1 GeneProduct ensembl:ENSG00000197249
TXNRD1 GeneProduct ensembl:ENSG00000198431
PCK1 GeneProduct ensembl:ENSG00000124253
FTH1 GeneProduct ensembl:ENSG00000167996
STAT3 GeneProduct ensembl:ENSG00000168610
NQO1 GeneProduct ensembl:ENSG00000181019
JUNB GeneProduct ensembl:ENSG00000171223
Metabolism Pathway wikipathways:WP702
G6PD GeneProduct ensembl:ENSG00000160211
CXCR7 GeneProduct ensembl:ENSG00000144476
AMIGO2 GeneProduct ensembl:ENSG00000139211
ADH7 GeneProduct ensembl:ENSG00000196344
MFGE8 GeneProduct ensembl:ENSG00000140545
SLC27A5 GeneProduct ensembl:ENSG00000083807
CYP2C19 GeneProduct ensembl:ENSG00000165841
TGFBR2 GeneProduct ensembl:ENSG00000163513
PRDX6 GeneProduct ensembl:ENSG00000117592
PRDX1 GeneProduct ensembl:ENSG00000117450
STOM GeneProduct ensembl:ENSG00000148175
SCNN1A GeneProduct ensembl:ENSG00000111319
MYOF GeneProduct ensembl:ENSG00000138119
Cell proliferationand apoptosis Pathway wikipathways:WP179
JUN GeneProduct ensembl:ENSG00000177606
GGT1 GeneProduct ensembl:ENSG00000100031
HSP90AB1 GeneProduct ensembl:ENSG00000096384
Co-activators Unknown None
NR1I3 GeneProduct ensembl:ENSG00000143257
ENC1 GeneProduct ensembl:ENSG00000171617
PPP1R14C GeneProduct ensembl:ENSG00000198729
CES2 GeneProduct ensembl:ENSG00000172831
ALOX5AP GeneProduct ensembl:ENSG00000132965
SQSTM1 GeneProduct ensembl:ENSG00000161011
GCLC GeneProduct ensembl:ENSG00000001084
GCC1 GeneProduct ensembl:ENSG00000179562
Antioxidantproteins Pathway wikipathways:WP408
UGT1A7 GeneProduct ensembl:ENSG00000244122
CES4A GeneProduct ensembl:ENSG00000172824
FGF13 GeneProduct ensembl:ENSG00000129682
PDE4B GeneProduct ensembl:ENSG00000184588
CYP3A4 GeneProduct ensembl:ENSG00000160868
CYP4A11 GeneProduct ensembl:ENSG00000187048
ABCC5 GeneProduct ensembl:ENSG00000114770
SLC2A7 GeneProduct ensembl:ENSG00000197241
bile acidconjugation Pathway wikipathways:WP1788
NR1H3 GeneProduct ensembl:ENSG00000025434
SLC2A13 GeneProduct ensembl:ENSG00000151229
PGD GeneProduct ensembl:ENSG00000142657
CYP7A1 GeneProduct ensembl:ENSG00000167910
SLC2A4 GeneProduct ensembl:ENSG00000181856
FASN GeneProduct ensembl:ENSG00000169710
GCLM GeneProduct ensembl:ENSG00000023909
AGER GeneProduct ensembl:ENSG00000204305
ACAA1 GeneProduct ensembl:ENSG00000060971
CDKN1C GeneProduct ensembl:ENSG00000129757
RXRA GeneProduct ensembl:ENSG00000186350
BLVRB GeneProduct ensembl:ENSG00000090013
UGT2B4 GeneProduct ensembl:ENSG00000156096
UGT1A9 GeneProduct ensembl:ENSG00000241119
FGFBP1 GeneProduct ensembl:ENSG00000137440
SREBF1 GeneProduct ensembl:ENSG00000072310
Inflammation Pathway wikipathways:WP453
UGT1A6 GeneProduct ensembl:ENSG00000167165
SERPINB2 GeneProduct ensembl:ENSG00000197632
SLC2A2 GeneProduct ensembl:ENSG00000163581
UGT1A4 GeneProduct ensembl:ENSG00000244474
BIRC2 GeneProduct ensembl:ENSG00000110330
CYP3A4 GeneProduct ensembl:ENSG00000160868
PMP2 GeneProduct ensembl:ENSG00000147588
GSTA5 GeneProduct ensembl:ENSG00000182793
AKAP13 GeneProduct ensembl:ENSG00000170776
TNS4 GeneProduct ensembl:ENSG00000131746
NRG1 GeneProduct ensembl:ENSG00000157168
KAT2B GeneProduct ensembl:ENSG00000114166
GSTT1 GeneProduct ensembl:ENSG00000277656
ME1 GeneProduct ensembl:ENSG00000065833
ABCC4 GeneProduct ensembl:ENSG00000125257
HMOX1 GeneProduct ensembl:ENSG00000100292
POLK GeneProduct ensembl:ENSG00000122008
ALAS1 GeneProduct ensembl:ENSG00000023330
SLC2A8 GeneProduct ensembl:ENSG00000136856
CBR3 GeneProduct ensembl:ENSG00000159231
GSTA2 GeneProduct ensembl:ENSG00000244067
SULT2A1 GeneProduct ensembl:ENSG00000105398
ESR1 GeneProduct ensembl:ENSG00000091831
SLC2A12 GeneProduct ensembl:ENSG00000146411
CYP2B6 GeneProduct ensembl:ENSG00000197408
GSTP1 GeneProduct ensembl:ENSG00000084207
CES3 GeneProduct ensembl:ENSG00000172828
UGT1A4 GeneProduct ensembl:ENSG00000244474
PPP2R4 GeneProduct ensembl:ENSG00000119383
EP300 GeneProduct ensembl:ENSG00000100393
TGFBR3 GeneProduct ensembl:ENSG00000069702
CYP3A7 GeneProduct ensembl:ENSG00000160870
ANKRD1 GeneProduct ensembl:ENSG00000148677
ABHD2 GeneProduct ensembl:ENSG00000140526
SPINK13 GeneProduct ensembl:ENSG00000214510
SERPINB9 GeneProduct ensembl:ENSG00000170542
HSP90AA1 GeneProduct ensembl:ENSG00000080824
UGT1A6 GeneProduct ensembl:ENSG00000167165
PPARGC1A GeneProduct ensembl:ENSG00000109819
EHHADH GeneProduct ensembl:ENSG00000113790
CYP2A6 GeneProduct ensembl:ENSG00000255974
SLC2A14 GeneProduct ensembl:ENSG00000173262
CUL1 GeneProduct ensembl:ENSG00000055130
ABCC2 GeneProduct ensembl:ENSG00000023839
DNER GeneProduct ensembl:ENSG00000187957
PLK2 GeneProduct ensembl:ENSG00000145632
ABCG8 GeneProduct ensembl:ENSG00000143921
PRRG4 GeneProduct ensembl:ENSG00000135378
UGT1A7 GeneProduct ensembl:ENSG00000244122
MGST1 GeneProduct ensembl:ENSG00000008394
SLC2A5 GeneProduct ensembl:ENSG00000142583
SLC2A3 GeneProduct ensembl:ENSG00000059804
FGF19 GeneProduct ensembl:ENSG00000162344
UGT1A1 GeneProduct ensembl:ENSG00000241635
NR1I3 GeneProduct ensembl:ENSG00000143257
DNAJC7 GeneProduct ensembl:ENSG00000168259
HSP90AA1 GeneProduct ensembl:ENSG00000080824
RXRA GeneProduct ensembl:ENSG00000186350
NR1I3 GeneProduct ensembl:ENSG00000143257
NCOA1 GeneProduct ensembl:ENSG00000084676
EGFR pathway Pathway wikipathways:WP1910
EP300 GeneProduct ensembl:ENSG00000100393
UGT1A6 GeneProduct ensembl:ENSG00000167165
AHRR GeneProduct ensembl:ENSG00000063438
SRC GeneProduct ensembl:ENSG00000197122
CDKN1B GeneProduct ensembl:ENSG00000111276
AIP GeneProduct ensembl:ENSG00000110711
CYP1B1 GeneProduct ensembl:ENSG00000138061
UGT1A1 GeneProduct ensembl:ENSG00000241635
ALDH3A1 GeneProduct ensembl:ENSG00000108602
GSTA2 GeneProduct ensembl:ENSG00000244067
AHR GeneProduct ensembl:ENSG00000106546
JUND GeneProduct ensembl:ENSG00000130522
NQO1 GeneProduct ensembl:ENSG00000181019
IGFBP1 GeneProduct ensembl:ENSG00000146678
NFE2L2 GeneProduct ensembl:ENSG00000116044
BAX GeneProduct ensembl:ENSG00000087088
JUN GeneProduct ensembl:ENSG00000177606
CYP1A2 GeneProduct ensembl:ENSG00000140505
EGFR GeneProduct ensembl:ENSG00000146648
HSP90AA1 GeneProduct ensembl:ENSG00000080824
TNF GeneProduct ensembl:ENSG00000232810
PTGES3 GeneProduct ensembl:ENSG00000110958
IL2 GeneProduct ensembl:ENSG00000109471
HES1 GeneProduct ensembl:ENSG00000114315
ARNT GeneProduct ncbigene:405
CDC37 GeneProduct ensembl:ENSG00000105401
CYP1A1 GeneProduct ensembl:ENSG00000140465
AHR GeneProduct ensembl:ENSG00000106546
ARNT GeneProduct ncbigene:405
AIP GeneProduct ensembl:ENSG00000110711
SRC GeneProduct ensembl:ENSG00000197122
SRC GeneProduct ensembl:ENSG00000197122
CDC37 GeneProduct ensembl:ENSG00000105401
AHR GeneProduct ensembl:ENSG00000106546
ARNT GeneProduct ncbigene:405
AHR GeneProduct ensembl:ENSG00000106546
Ligand Protein None
Ligand Protein None
Ligand Protein None
UGT1A9 GeneProduct ensembl:ENSG00000241119
Hepatocyteproliferation Pathway wikipathways:WP313
NR1H3 GeneProduct ensembl:ENSG00000025434
SCP2 GeneProduct ensembl:ENSG00000116171
CPT1A GeneProduct ensembl:ENSG00000110090
APOC3 GeneProduct ensembl:ENSG00000110245
FABP1 GeneProduct ensembl:ENSG00000163586
CCND1 GeneProduct ensembl:ENSG00000110092
PLTP GeneProduct ensembl:ENSG00000100979
DBI GeneProduct ensembl:ENSG00000155368
APOA2 GeneProduct ensembl:ENSG00000158874
CPT2 GeneProduct ensembl:ENSG00000157184
APOA1 GeneProduct ensembl:ENSG00000118137
CYP4A11 GeneProduct ensembl:ENSG00000187048
ACADM GeneProduct ensembl:ENSG00000117054
CDK4 GeneProduct ensembl:ENSG00000135446
CYP7A1 GeneProduct ensembl:ENSG00000167910
MYC GeneProduct ensembl:ENSG00000136997
mitochondrialomega-oxidation Pathway wikipathways:WP206
SLC27A1 GeneProduct ensembl:ENSG00000130304
Cholesterolcatabolism Pathway wikipathways:WP4190
peroxisomalbeta-oxidation Pathway wikipathways:WP1878
KLK15 GeneProduct ensembl:ENSG00000174562
APOA5 GeneProduct ensembl:ENSG00000110243
CDK1 GeneProduct ensembl:ENSG00000170312
CYP8B1 GeneProduct ensembl:ENSG00000180432
PPAR alpha ligand Unknown None
PPARA GeneProduct ensembl:ENSG00000186951
PPARA GeneProduct ensembl:ENSG00000186951
RXRA GeneProduct ensembl:ENSG00000186350
Ligand Unknown None
lipoproteinmetabolism Pathway wikipathways:WP4129
fatty acidtransport Pathway wikipathways:WP357
mitochondrialbeta-oxidation Pathway wikipathways:WP368
SLCO1B1 GeneProduct ensembl:ENSG00000134538
HSP90AA1 GeneProduct ensembl:ENSG00000080824
NR1I2 GeneProduct ensembl:ENSG00000144852
SRPX2 GeneProduct ensembl:ENSG00000102359
NCOA3 GeneProduct ensembl:ENSG00000124151
FOXO1 GeneProduct ensembl:ENSG00000150907
CYP4F12 GeneProduct ensembl:ENSG00000186204
CYP3A4 GeneProduct ensembl:ENSG00000160868
UGT1A1 GeneProduct ensembl:ENSG00000241635
DNAJC7 GeneProduct ensembl:ENSG00000168259
ABCC4 GeneProduct ensembl:ENSG00000125257
NRIP1 GeneProduct ensembl:ENSG00000180530
Unknown Unknown None
CYP2B6 GeneProduct ensembl:ENSG00000197408
GSTA2 GeneProduct ensembl:ENSG00000244067
PSMC5 GeneProduct ensembl:ENSG00000087191
PPARGC1A GeneProduct ensembl:ENSG00000109819
NCOA1 GeneProduct ensembl:ENSG00000084676
NCOA2 GeneProduct ensembl:ENSG00000140396
ABCB1 GeneProduct ensembl:ENSG00000085563
NR1I2 GeneProduct ensembl:ENSG00000144852
RXRA GeneProduct ensembl:ENSG00000186350
NR1I2 GeneProduct ensembl:ENSG00000144852
Co-activators Unknown None
NR1I3 GeneProduct ensembl:ENSG00000143257
NR1I2 GeneProduct ensembl:ENSG00000144852
NR3C1 GeneProduct ensembl:ENSG00000113580
RXRA GeneProduct ensembl:ENSG00000186350
NR1I3 GeneProduct ensembl:ENSG00000143257
NR1I2 GeneProduct ensembl:ENSG00000144852
NR3C1 GeneProduct ensembl:ENSG00000113580
HSP90AA1 GeneProduct ensembl:ENSG00000080824
p23 GeneProduct ensembl:ENSG00000110958
HSP90AA1 GeneProduct ensembl:ENSG00000080824
p23 GeneProduct ensembl:ENSG00000110958
NR3C1 GeneProduct ensembl:ENSG00000113580
HSP90AA1 GeneProduct ensembl:ENSG00000080824
p23 GeneProduct ensembl:ENSG00000110958
NR3C1 GeneProduct ensembl:ENSG00000113580
NR3C1 GeneProduct ensembl:ENSG00000113580
NR3C1 GeneProduct ensembl:ENSG00000113580
NR3C1 GeneProduct ensembl:ENSG00000113580
NR3C1 GeneProduct ensembl:ENSG00000113580
NR3C1 GeneProduct ensembl:ENSG00000113580
NR1H3 GeneProduct ensembl:ENSG00000025434
RXRA GeneProduct ensembl:ENSG00000186350
PTGES3 GeneProduct ensembl:ENSG00000110958
RXRA GeneProduct ensembl:ENSG00000186350
NR1H3 GeneProduct ensembl:ENSG00000025434
CYP2B6 GeneProduct ensembl:ENSG00000197408
CYP2C9 GeneProduct ensembl:ENSG00000138109
VDR GeneProduct ensembl:ENSG00000111424
RXRA GeneProduct ensembl:ENSG00000186350
CYP3A4 GeneProduct ensembl:ENSG00000160868
VDR GeneProduct ensembl:ENSG00000111424
RXRA GeneProduct ensembl:ENSG00000186350
VDR GeneProduct ensembl:ENSG00000111424
ESR1 GeneProduct ensembl:ENSG00000091831
ESR1 GeneProduct ensembl:ENSG00000091831
ESR1 GeneProduct ensembl:ENSG00000091831
ESR1 GeneProduct ensembl:ENSG00000091831
ESR1 GeneProduct ensembl:ENSG00000091831
ESR1 GeneProduct ensembl:ENSG00000091831
ESR1 GeneProduct ensembl:ENSG00000091831
NR1H3 GeneProduct ensembl:ENSG00000025434
RXRA GeneProduct ensembl:ENSG00000186350
NR1H4 GeneProduct ensembl:ENSG00000012504
RXRA GeneProduct ensembl:ENSG00000186350
NR1H4 GeneProduct ensembl:ENSG00000012504
RXRA GeneProduct ensembl:ENSG00000186350
Bile aciddetoxification Pathway wikipathways:WP1788
NR1H4 GeneProduct ensembl:ENSG00000012504
UGT1A4 GeneProduct ensembl:ENSG00000244474
UGT1A6 GeneProduct ensembl:ENSG00000167165
UGT1A9 GeneProduct ensembl:ENSG00000241119
UGT1A3 GeneProduct ensembl:ENSG00000243135
CYP2C9 GeneProduct ensembl:ENSG00000138109
CYP3A5 GeneProduct ensembl:ENSG00000106258
CYP2C19 GeneProduct ensembl:ENSG00000165841
SULT2A1 GeneProduct ensembl:ENSG00000105398
ABCC2 GeneProduct ensembl:ENSG00000023839
ABCC3 GeneProduct ensembl:ENSG00000108846
EHHADH GeneProduct ensembl:ENSG00000113790
FOXO1 GeneProduct ensembl:ENSG00000150907
Inflammation Pathway wikipathways:WP453
Growth andapoptosis Pathway wikipathways:WP2657
Signaltransduction Pathway wikipathways:WP1909
Inflammation Pathway wikipathways:WP453
Growth andapoptosis Pathway wikipathways:WP2657
Signaltransduction Pathway wikipathways:WP1909
Metabolism Pathway wikipathways:WP702
Transport Pathway wikipathways:WP1936
Nuclearreceptors Pathway None
Multi-drugresistance Pathway wikipathways:WP2489
Drug and steroidmetabolism Pathway wikipathways:WP496
Phase 2metabolism Pathway wikipathways:WP702
Multi-drugresistance Pathway wikipathways:WP2489
Phase 2metabolism Pathway wikipathways:WP702
Drug and steroidmetabolism Pathway wikipathways:WP496
Phase 2metabolism Pathway wikipathways:WP702
Drug and steroidmetabolism Pathway wikipathways:WP496
Multi-drugresistance Pathway wikipathways:WP2489
Transcriptionfactors Pathway wikipathways:WP1822
Drug and steroidmetabolism Pathway wikipathways:WP496
Transcriptionfactors Pathway wikipathways:WP1822
Drug and steroidmetabolism Pathway wikipathways:WP496
RXRA GeneProduct ensembl:ENSG00000186350
Phase 1proteins Pathway wikipathways:WP702
Phase 2proteins Pathway wikipathways:WP702
GSTM5 GeneProduct ensembl:ENSG00000134201
GSTM1 GeneProduct ensembl:ENSG00000134184
GSTM2 GeneProduct ensembl:ENSG00000213366
GSTM3 GeneProduct ensembl:ENSG00000134202
GSTM4 GeneProduct ensembl:ENSG00000168765
Transport Pathway wikipathways:WP1936
SLC5A2 GeneProduct ensembl:ENSG00000140675
SLC5A1 GeneProduct ensembl:ENSG00000100170
SLC5A4 GeneProduct ensembl:ENSG00000100191
SLC5A10 GeneProduct ensembl:ENSG00000154025
SLC5A9 GeneProduct ensembl:ENSG00000117834
SLC5A6 GeneProduct ensembl:ENSG00000138074
SLC5A11 GeneProduct ensembl:ENSG00000158865
SLC5A12 GeneProduct ensembl:ENSG00000148942
SLC5A3 GeneProduct ensembl:ENSG00000198743
SLC5A7 GeneProduct ensembl:ENSG00000115665
SLC5A8 GeneProduct ensembl:ENSG00000256870
SLC5A5 GeneProduct ensembl:ENSG00000105641
SLC6A2 GeneProduct ensembl:ENSG00000103546
SLC6A1 GeneProduct ensembl:ENSG00000157103
SLC6A4 GeneProduct ensembl:ENSG00000108576
SLC6A11 GeneProduct ensembl:ENSG00000132164
SLC6A9 GeneProduct ensembl:ENSG00000196517
SLC6A6 GeneProduct ensembl:ENSG00000131389
SLC6A13 GeneProduct ensembl:ENSG00000010379
SLC6A14 GeneProduct ensembl:ENSG00000268104
SLC6A3 GeneProduct ensembl:ENSG00000142319
SLC6A7 GeneProduct ensembl:ENSG00000011083
SLC6A8 GeneProduct ensembl:ENSG00000130821
SLC6A5 GeneProduct ensembl:ENSG00000165970
SLC6A16 GeneProduct ensembl:ENSG00000063127
SLC6A15 GeneProduct ensembl:ENSG00000072041
SLC6A18 GeneProduct ensembl:ENSG00000164363
SLC6A20 GeneProduct ensembl:ENSG00000163817
SLC6A17 GeneProduct ensembl:ENSG00000197106
SLC6A19 GeneProduct ensembl:ENSG00000174358
SLC39A2 GeneProduct ensembl:ENSG00000165794
SLC39A1 GeneProduct ensembl:ENSG00000143570
SLC39A4 GeneProduct ensembl:ENSG00000147804
SLC39A10 GeneProduct ensembl:ENSG00000196950
SLC39A9 GeneProduct ensembl:ENSG00000029364
SLC39A6 GeneProduct ensembl:ENSG00000141424
SLC39A11 GeneProduct ensembl:ENSG00000133195
SLC39A12 GeneProduct ensembl:ENSG00000148482
SLC39A3 GeneProduct ensembl:ENSG00000141873
SLC39A7 GeneProduct ensembl:ENSG00000112473
SLC39A8 GeneProduct ensembl:ENSG00000138821
SLC39A5 GeneProduct ensembl:ENSG00000139540
SLC39A13 GeneProduct ensembl:ENSG00000165915
SLC39A14 GeneProduct ensembl:ENSG00000104635
Growth factorsand receptors Pathway wikipathways:WP2657
NFE2L2 GeneProduct ensembl:ENSG00000116044
KEAP1 GeneProduct ensembl:ENSG00000079999
NFE2L2 GeneProduct ensembl:ENSG00000116044
NFE2L2 GeneProduct ensembl:ENSG00000116044
NFE2L2 GeneProduct ensembl:ENSG00000116044
SCD GeneProduct ensembl:ENSG00000099194

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