NRF2 pathway (WP2884)

NRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2884 CPTAC Assay Portal]
last edited

Authors

Riannefijten, MaintBot, Bart Smeets, Fehrhart, Egonw, Zari, Mkutmon, Elisa, AlexanderPico, L Dupuis, Susan, and Khanspers

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: regulatory pathway nuclear factor, erythroid 2 like 2 signaling pathway

Participants

Label Type Compact Identifier
Ligand Metabolite chebi:48705
SLC2A1 GeneProduct ensembl:ENSG00000117394
CES3 GeneProduct ensembl:ENSG00000172828
ME1 GeneProduct ensembl:ENSG00000065833
PRDX1 GeneProduct ensembl:ENSG00000117450
GSTA1 GeneProduct ensembl:ENSG00000243955
SLC2A11 GeneProduct ensembl:ENSG00000133460
GPX2 GeneProduct ensembl:ENSG00000176153
HGF GeneProduct ensembl:ENSG00000019991
UGT1A4 GeneProduct ensembl:ENSG00000244474
FGF13 GeneProduct ensembl:ENSG00000129682
BLVRB GeneProduct ensembl:ENSG00000090013
GCLC GeneProduct ensembl:ENSG00000001084
MGST3 GeneProduct ensembl:ENSG00000143198
SLC7A11 GeneProduct ensembl:ENSG00000151012
NFE2L2 GeneProduct ensembl:ENSG00000116044
GSTA3 GeneProduct ensembl:ENSG00000174156
SLC2A13 GeneProduct ensembl:ENSG00000151229
ABCC2 GeneProduct ensembl:ENSG00000023839
TXN GeneProduct ensembl:ENSG00000136810
ABCC4 GeneProduct ensembl:ENSG00000125257
SOD3 GeneProduct ensembl:ENSG00000109610
SLC2A9 GeneProduct ensembl:ENSG00000109667
GPX3 GeneProduct ensembl:ENSG00000211445
ADH7 GeneProduct ensembl:ENSG00000196344
EPHA3 GeneProduct ensembl:ENSG00000044524
GSR GeneProduct ensembl:ENSG00000104687
HSP90AB1 GeneProduct ensembl:ENSG00000096384
GSTT1 GeneProduct ensembl:ENSG00000277656
SLC2A7 GeneProduct ensembl:ENSG00000197241
SLC2A14 GeneProduct ensembl:ENSG00000173262
SRXN1 GeneProduct ensembl:ENSG00000271303
UGT1A7 GeneProduct ensembl:ENSG00000244122
PGD GeneProduct ensembl:ENSG00000142657
CBR1 GeneProduct ensembl:ENSG00000159228
ALDH3A1 GeneProduct ensembl:ENSG00000108602
CYP2A6 GeneProduct ensembl:ENSG00000255974
PPARD GeneProduct ensembl:ENSG00000112033
CBR3 GeneProduct ensembl:ENSG00000159231
TGFB1 GeneProduct ensembl:ENSG00000105329
G6PD GeneProduct ensembl:ENSG00000160211
UGT1A6 GeneProduct ensembl:ENSG00000167165
TXNRD1 GeneProduct ensembl:ENSG00000198431
TGFB2 GeneProduct ensembl:ENSG00000092969
ABCC3 GeneProduct ensembl:ENSG00000108846
UGT1A9 GeneProduct ensembl:ENSG00000241119
GSTP1 GeneProduct ensembl:ENSG00000084207
CES5A GeneProduct ensembl:ENSG00000159398
PTGR1 GeneProduct ensembl:ENSG00000106853
GSTA5 GeneProduct ensembl:ENSG00000182793
UGT1A1 GeneProduct ensembl:ENSG00000241635
PRDX6 GeneProduct ensembl:ENSG00000117592
HSP90AA1 GeneProduct ensembl:ENSG00000080824
GGT1 GeneProduct ensembl:ENSG00000100031
GSTA4 GeneProduct ensembl:ENSG00000170899
NQO1 GeneProduct ensembl:ENSG00000181019
DNAJB1 GeneProduct ensembl:ENSG00000132002
CES1 GeneProduct ensembl:ENSG00000198848
CES4A GeneProduct ensembl:ENSG00000172824
TGFA GeneProduct ensembl:ENSG00000163235
GSTT2 GeneProduct ensembl:ENSG00000099984
UGT2B7 GeneProduct ensembl:ENSG00000171234
SLC2A10 GeneProduct ensembl:ENSG00000197496
SLC2A12 GeneProduct ensembl:ENSG00000146411
GSTA2 GeneProduct ensembl:ENSG00000244067
GCLM GeneProduct ensembl:ENSG00000023909
ABCC5 GeneProduct ensembl:ENSG00000114770
MAFF GeneProduct ensembl:ENSG00000185022
NRG1 GeneProduct ensembl:ENSG00000157168
SLC2A5 GeneProduct ensembl:ENSG00000142583
MGST2 GeneProduct ensembl:ENSG00000085871
SERPINA1 GeneProduct ensembl:ENSG00000197249
SQSTM1 GeneProduct ensembl:ENSG00000161011
EGR1 GeneProduct ensembl:ENSG00000120738
CES2 GeneProduct ensembl:ENSG00000172831
SLC2A4 GeneProduct ensembl:ENSG00000181856
SLC2A2 GeneProduct ensembl:ENSG00000163581
UGT1A3 GeneProduct ensembl:ENSG00000243135
SLC2A6 GeneProduct ensembl:ENSG00000160326
SLC2A8 GeneProduct ensembl:ENSG00000136856
FTL GeneProduct ensembl:ENSG00000087086
EPHA2 GeneProduct ensembl:ENSG00000142627
HMOX1 GeneProduct ensembl:ENSG00000100292
MAFG GeneProduct ensembl:ENSG00000197063
HBEGF GeneProduct ensembl:ENSG00000113070
HSPA1A GeneProduct ensembl:ENSG00000204389
KEAP1 GeneProduct ensembl:ENSG00000079999
FTH1 GeneProduct ensembl:ENSG00000167996
TGFBR2 GeneProduct ensembl:ENSG00000163513
SLC2A3 GeneProduct ensembl:ENSG00000059804
PDGFB GeneProduct ensembl:ENSG00000100311
AGER GeneProduct ensembl:ENSG00000204305
TXNRD3 GeneProduct ensembl:ENSG00000197763
CYP4A11 GeneProduct ensembl:ENSG00000187048
RXRA GeneProduct ensembl:ENSG00000186350
Ligand Metabolite chebi:48705
GSTM5 GeneProduct ensembl:ENSG00000134201
GSTM1 GeneProduct ensembl:ENSG00000134184
GSTM2 GeneProduct ensembl:ENSG00000213366
GSTM3 GeneProduct ensembl:ENSG00000134202
GSTM4 GeneProduct ensembl:ENSG00000168765
SLC5A2 GeneProduct ensembl:ENSG00000140675
SLC5A1 GeneProduct ensembl:ENSG00000100170
SLC5A4 GeneProduct ensembl:ENSG00000100191
SLC5A10 GeneProduct ensembl:ENSG00000154025
SLC5A9 GeneProduct ensembl:ENSG00000117834
SLC5A6 GeneProduct ensembl:ENSG00000138074
SLC5A11 GeneProduct ensembl:ENSG00000158865
SLC5A12 GeneProduct ensembl:ENSG00000148942
SLC5A3 GeneProduct ensembl:ENSG00000198743
SLC5A7 GeneProduct ensembl:ENSG00000115665
SLC5A8 GeneProduct ensembl:ENSG00000256870
SLC5A5 GeneProduct ensembl:ENSG00000105641
SLC6A2 GeneProduct ensembl:ENSG00000103546
SLC6A1 GeneProduct ensembl:ENSG00000157103
SLC6A4 GeneProduct ensembl:ENSG00000108576
SLC6A11 GeneProduct ensembl:ENSG00000132164
SLC6A9 GeneProduct ensembl:ENSG00000196517
SLC6A6 GeneProduct ensembl:ENSG00000131389
SLC6A13 GeneProduct ensembl:ENSG00000010379
SLC6A14 GeneProduct ensembl:ENSG00000268104
SLC6A3 GeneProduct ensembl:ENSG00000142319
SLC6A7 GeneProduct ensembl:ENSG00000011083
SLC6A8 GeneProduct ensembl:ENSG00000130821
SLC6A5 GeneProduct ensembl:ENSG00000165970
SLC6A16 GeneProduct ensembl:ENSG00000063127
SLC6A15 GeneProduct ensembl:ENSG00000072041
SLC6A18 GeneProduct ensembl:ENSG00000164363
SLC6A20 GeneProduct ensembl:ENSG00000163817
SLC6A17 GeneProduct ensembl:ENSG00000197106
SLC6A19 GeneProduct ensembl:ENSG00000174358
SLC39A2 GeneProduct ensembl:ENSG00000165794
SLC39A1 GeneProduct ensembl:ENSG00000143570
SLC39A4 GeneProduct ensembl:ENSG00000147804
SLC39A10 GeneProduct ensembl:ENSG00000196950
SLC39A9 GeneProduct ensembl:ENSG00000029364
SLC39A6 GeneProduct ensembl:ENSG00000141424
SLC39A11 GeneProduct ensembl:ENSG00000133195
SLC39A12 GeneProduct ensembl:ENSG00000148482
SLC39A3 GeneProduct ensembl:ENSG00000141873
SLC39A7 GeneProduct ensembl:ENSG00000112473
SLC39A8 GeneProduct ensembl:ENSG00000138821
SLC39A5 GeneProduct ensembl:ENSG00000139540
SLC39A13 GeneProduct ensembl:ENSG00000165915
SLC39A14 GeneProduct ensembl:ENSG00000104635
NFE2L2 GeneProduct ensembl:ENSG00000116044
KEAP1 GeneProduct ensembl:ENSG00000079999
NFE2L2 GeneProduct ensembl:ENSG00000116044
Ligand Metabolite chebi:48705
NFE2L2 GeneProduct ensembl:ENSG00000116044

References

  1. Banning A, Deubel S, Kluth D, Zhou Z, Brigelius-Flohé R. The GI-GPx gene is a target for Nrf2. Mol Cell Biol. 2005 Jun;25(12):4914–23. PubMed Europe PMC Scholia
  2. Hayes JD, McMahon M. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci. 2009 Apr;34(4):176–88. PubMed Europe PMC Scholia
  3. Müller M, Banning A, Brigelius-Flohé R, Kipp A. Nrf2 target genes are induced under marginal selenium-deficiency. Genes Nutr. 2010 Dec;5(4):297–307. PubMed Europe PMC Scholia
  4. Bock KW. From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans. Biochem Pharmacol. 2011 Jul 1;82(1):9–16. PubMed Europe PMC Scholia
  5. Fijten RRR, Jennen DGJ, van Delft JHM. Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia