IGF-1 signaling (WP2892)

The activated IGF-1R (Insulin-like growth factor 1 receptor) regulates cellular adhesion, cytoskeletal organization and migration through interaction with adhesion molecules and integrin. In normal physiology the IGF-1R stimulates linear body growth, promotes neuronal survival and myelination, postnatal mammary gland development and lactation and is implicated in bone formation and renal function (Fortes et al,2013).
last edited


Zari, Mkutmon, Evelo, Egonw, Khanspers, Jmelius, and Eweitz

Cited In


Bos taurus



Pathway Ontology: signaling pathway


Label Type Compact Identifier
KRAS GeneProduct ncbigene:541140
MTOR GeneProduct ncbigene:100139219
AKT1 GeneProduct ensembl:ENSBTAG00000017636
RAF1 GeneProduct ncbigene:521196
MAPK12 GeneProduct ncbigene:512943
SHC3 GeneProduct ncbigene:512696
BRAF GeneProduct ensembl:ENSBTAG00000021761
MAPK13 GeneProduct ncbigene:535327
IRS2 GeneProduct ensembl:ENSBTAG00000012019
MAPK3 GeneProduct ncbigene:531391
MAPK10 GeneProduct ncbigene:537631
MAPK9 GeneProduct ncbigene:534125
AKT2 GeneProduct ncbigene:534923
MAPK11 GeneProduct ncbigene:618906
IRS1 GeneProduct ensembl:ENSBTAG00000021308
IGF1R GeneProduct ncbigene:281848
BAD GeneProduct ncbigene:615013
MAPK15 GeneProduct ncbigene:512125
NRAS GeneProduct ncbigene:506322
ARAF GeneProduct ncbigene:540421
PIK3 GeneProduct None
SHC1 GeneProduct ncbigene:507196
MAPK4 GeneProduct ensembl:ENSBTAG00000009907
SHC4 GeneProduct ncbigene:524734
MAPK7 GeneProduct ncbigene:537703
MAPK1 GeneProduct ensembl:ENSBTAG00000010312
MAPK6 GeneProduct ncbigene:538094
IGF1 GeneProduct ncbigene:281239
HRAS GeneProduct ncbigene:100298939
MAPK14 GeneProduct ncbigene:534492
MAPK8 GeneProduct ensembl:ENSBTAG00000007876
SHC2 GeneProduct ensembl:ENSBTAG00000016072
AKT3 GeneProduct ncbigene:100137872


  1. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev. 1995 Feb;16(1):3–34. PubMed Europe PMC Scholia
  2. Fortes MRS, Li Y, Collis E, Zhang Y, Hawken RJ. The IGF1 pathway genes and their association with age of puberty in cattle. Anim Genet. 2013 Feb;44(1):91–5. PubMed Europe PMC Scholia