Differentiation of white and brown adipocyte (WP2895)

Development of white versus brown adipocytes (figure from Handbook of Obesity). Transcription factors and nuclear regulators controlling the development of white versus brown adipocytes are shown in the pathway. At the bottom a selection of identified markers of white and brown adipocytes were added (from Nascimento et al).
last edited


Mkutmon, Egonw, Susan, Eweitz, and Marvin M2

Cited In


Homo sapiens



Pathway Ontology: regulatory pathway


Label Type Compact Identifier
ZIC1 GeneProduct ensembl:ENSG00000152977
PLAC8 GeneProduct ensembl:ENSG00000145287
PGC-1α GeneProduct ensembl:ENSG00000109819
PGC-1β GeneProduct ensembl:ENSG00000155846
BMP2 GeneProduct ensembl:ENSG00000125845
BMP4 GeneProduct ensembl:ENSG00000125378
Smad1 GeneProduct ensembl:ENSG00000170365
Smad8 GeneProduct ensembl:ENSG00000120693
C/EBPβ GeneProduct ensembl:ENSG00000172216
C/EBPδ GeneProduct ensembl:ENSG00000153879
PRDM16 GeneProduct ensembl:ENSG00000142611
BMP7 GeneProduct ensembl:ENSG00000101144
Smad9 GeneProduct ensembl:ENSG00000120693
EBF3 GeneProduct ensembl:ENSG00000108001
Adiponectin GeneProduct ensembl:ENSG00000181092
Leptin GeneProduct ensembl:ENSG00000174697
C/EBPα GeneProduct ensembl:ENSG00000245848
ASC-1 GeneProduct ensembl:ENSG00000130876
PPARγ GeneProduct ensembl:ENSG00000132170
Smad5 GeneProduct ensembl:ENSG00000113658
HSPB7 GeneProduct ensembl:ENSG00000173641
HOXC9 GeneProduct ensembl:ENSG00000180806
Zfp423 GeneProduct ensembl:ENSG00000102935
EVA1 GeneProduct ensembl:ENSG00000149573
CIDEA GeneProduct ensembl:ENSG00000176194
PRDM16 GeneProduct ensembl:ENSG00000142611
HOXC8 GeneProduct ensembl:ENSG00000037965
PRDM16 GeneProduct ensembl:ENSG00000142611
Smad5 GeneProduct ensembl:ENSG00000113658
Smad1 GeneProduct ensembl:ENSG00000170365
C/EBPβ GeneProduct ensembl:ENSG00000172216


  1. Nascimento EBM, Boon MR, van Marken Lichtenbelt WD. Fat cells gain new identities. Sci Transl Med. 2014 Jul 30;6(247):247fs29. PubMed Europe PMC Scholia