p53 signaling (WP2902)

http://www.kegg.jp/ (mmu04115) p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
last edited

Authors

Lindarieswijk, MaintBot, Egonw, Jmelius, and Fehrhart

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: p53 signaling pathway

Participants

Label Type Compact Identifier
Ccnd3 GeneProduct ncbigene:12445
Cdk4 GeneProduct ncbigene:12567
Ccnb1 GeneProduct ncbigene:268697
Ccnb2 GeneProduct ncbigene:12442
Ccnb3 GeneProduct ncbigene:209091
Gm5593 GeneProduct ensembl:ENSMUSG00000048574
Cycs GeneProduct ncbigene:13063
Rrm2 GeneProduct ncbigene:20135
Sesn3 GeneProduct ncbigene:75747
Ccng1 GeneProduct ncbigene:12450
Ccng2 GeneProduct ncbigene:12452
mmu-miR-291b-3p GeneProduct mirbase.mature:mmu-miR-291b-3p
mmu-miR-295-3p GeneProduct mirbase.mature:mmu-miR-295-3p
mmu-miR-302d-3p GeneProduct mirbase.mature:mmu-miR-302d-3p
mmu-miR-18a-5p GeneProduct mirbase.mature:mmu-miR-18a-5p
mmu-miR-20a-5p GeneProduct mirbase.mature:mmu-miR-20a-5p
mmu-miR-181b-5p GeneProduct mirbase.mature:mmu-miR-181b-5p
mmu-miR-223-3p GeneProduct mirbase.mature:mmu-miR-223-3p
mmu-miR-122-5p GeneProduct mirbase.mature:mmu-miR-122-5p
mmu-miR-216a-5p GeneProduct mirbase.mature:mmu-miR-216a-5p
mmu-miR-362-5p GeneProduct mirbase.mature:mmu-miR-362-5p
Sesn2 GeneProduct ncbigene:230784
mmu-miR-19b-3p GeneProduct mirbase.mature:mmu-miR-19b-3p
mmu-miR-449a-5p GeneProduct mirbase.mature:mmu-miR-449a-5p
Mdm2 GeneProduct ncbigene:17246
Siah1a GeneProduct ncbigene:20437
Sesn1 GeneProduct ncbigene:140742
mmu-miR-145a-5p GeneProduct mirbase.mature:mmu-miR-145a-5p
Ccne2 GeneProduct ncbigene:12448
mmu-miR-503-5p GeneProduct mirbase.mature:mmu-miR-503-5p
Serpine1 GeneProduct ncbigene:18787
Pmaip1 GeneProduct ncbigene:58801
Pten GeneProduct ncbigene:19211
Ei24 GeneProduct ncbigene:13663
mmu-miR-1a-3p GeneProduct mirbase.mature:mmu-miR-1a-3p
mmu-miR-9-5p GeneProduct mirbase.mature:mmu-miR-9-5p
mmu-miR-294-3p GeneProduct mirbase.mature:mmu-miR-294-3p
Thbs1 GeneProduct ncbigene:21825
mmu-miR-7b-5p GeneProduct mirbase.mature:mmu-miR-7b-5p
mmu-let-7b-5p GeneProduct mirbase.mature:mmu-let-7b-5p
Rprm GeneProduct ncbigene:67874
Atm GeneProduct ncbigene:11920
mmu-miR-758-3p GeneProduct mirbase.mature:mmu-miR-758-3p
mmu-miR-291a-3p GeneProduct mirbase.mature:mmu-miR-291a-3p
Gtse1 GeneProduct ncbigene:29870
Ccne1 GeneProduct ncbigene:12447
mmu-miR-30e-5p GeneProduct mirbase.mature:mmu-miR-30e-5p
Fas GeneProduct ncbigene:14102
mmu-miR-195a-5p GeneProduct mirbase.mature:mmu-miR-195a-5p
mmu-miR-17-5p GeneProduct mirbase.mature:mmu-miR-17-5p
mmu-miR-21-5p GeneProduct mirbase.mature:mmu-miR-21-5p
mmu-miR-34b-5p GeneProduct mirbase.mature:mmu-miR-34b-5p
Ccnd1 GeneProduct ncbigene:12443
Serpinb5 GeneProduct ncbigene:20724
Rrm2b GeneProduct ncbigene:382985
Cdkn1a GeneProduct ncbigene:12575
Casp3 GeneProduct ncbigene:12367
Gadd45a GeneProduct ncbigene:13197
Chek2 GeneProduct ncbigene:50883
Casp9 GeneProduct ncbigene:12371
Apaf1 GeneProduct ncbigene:11783
Cyct GeneProduct ncbigene:13067
mmu-miR-301b-3p GeneProduct mirbase.mature:mmu-miR-301b-3p
Perp GeneProduct ncbigene:64058
mmu-miR-29b-3p GeneProduct mirbase.mature:mmu-miR-29b-3p
Bai1 GeneProduct ncbigene:107831
Siah1b GeneProduct ncbigene:20438
mmu-miR-425-5p GeneProduct mirbase.mature:mmu-miR-425-5p
Bax GeneProduct ncbigene:12028
Cdk2 GeneProduct ncbigene:12566
Steap3 GeneProduct ncbigene:68428
mmu-miR-340-5p GeneProduct mirbase.mature:mmu-miR-340-5p
Chek1 GeneProduct ncbigene:12649
Sfn GeneProduct ncbigene:55948
Gadd45g GeneProduct ncbigene:23882
Igf1 GeneProduct ncbigene:16000
mmu-miR-124-3p GeneProduct mirbase.mature:mmu-miR-124-3p
mmu-miR-149-5p GeneProduct mirbase.mature:mmu-miR-149-5p
Rfwd2 GeneProduct ncbigene:26374
Atr GeneProduct ncbigene:245000
Mdm4 GeneProduct ncbigene:17248
Trp53 GeneProduct ncbigene:22059
Tsc2 GeneProduct ncbigene:22084
Cdk1 GeneProduct ncbigene:12534
Gadd45b GeneProduct ncbigene:17873
mmu-miR-24-3p GeneProduct mirbase.mature:mmu-miR-24-3p
Shisa5 GeneProduct ncbigene:66940
mmu-miR-103a-3p GeneProduct mirbase.mature:mmu-miR-103a-3p
Cd82 GeneProduct ncbigene:12521
Bbc3 GeneProduct ncbigene:170770
mmu-miR-181a-5p GeneProduct mirbase.mature:mmu-miR-181a-5p
mmu-miR-16-5p GeneProduct mirbase.mature:mmu-miR-16-5p
Zmat3 GeneProduct ncbigene:22401
Pidd1 GeneProduct ncbigene:57913
Ccnd2 GeneProduct ncbigene:12444
Rchy1 GeneProduct ncbigene:68098
Cdkn2a GeneProduct ncbigene:12578
Igfbp3 GeneProduct ncbigene:16009
Ddb2 GeneProduct ncbigene:107986
Ppm1d GeneProduct ncbigene:53892
Cdk6 GeneProduct ncbigene:12571
Casp8 GeneProduct ncbigene:12370
mmu-miR-486-5p GeneProduct mirbase.mature:mmu-miR-486-5p
mmu-miR-297a-5p GeneProduct mirbase.mature:mmu-miR-297a-5p
mmu-miR-217-5p GeneProduct mirbase.mature:mmu-miR-217-5p
Trp73 GeneProduct ncbigene:22062
mmu-miR-15a-5p GeneProduct mirbase.mature:mmu-miR-15a-5p
mmu-miR-21a-5p GeneProduct mirbase.mature:mmu-miR-21a-5p
Bid GeneProduct ncbigene:12122
Gadd45g GeneProduct ncbigene:23882
Gadd45b GeneProduct ncbigene:17873
Gadd45a GeneProduct ncbigene:13197
Igfbp3 GeneProduct ncbigene:16009
Mdm2 GeneProduct ncbigene:17246
Siah1a GeneProduct ncbigene:20437
Siah1b GeneProduct ncbigene:20438
mmu-miR-425-5p GeneProduct mirbase.mature:mmu-miR-425-5p
mmu-miR-16-5p GeneProduct mirbase.mature:mmu-miR-16-5p
mmu-miR-17-5p GeneProduct mirbase.mature:mmu-miR-17-5p
mmu-miR-301b-3p GeneProduct mirbase.mature:mmu-miR-301b-3p
mmu-miR-301b-3p GeneProduct mirbase.mature:mmu-miR-301b-3p
mmu-miR-301b-3p GeneProduct mirbase.mature:mmu-miR-301b-3p
mmu-miR-19b-3p GeneProduct mirbase.mature:mmu-miR-19b-3p
mmu-miR-19b-3p GeneProduct mirbase.mature:mmu-miR-19b-3p
mmu-miR-19b-3p GeneProduct mirbase.mature:mmu-miR-19b-3p
mmu-miR-503-5p GeneProduct mirbase.mature:mmu-miR-503-5p
mmu-let-7b-5p GeneProduct mirbase.mature:mmu-let-7b-5p
mmu-miR-19b-3p GeneProduct mirbase.mature:mmu-miR-19b-3p
mmu-miR-340-5p GeneProduct mirbase.mature:mmu-miR-340-5p
mmu-miR-34b-5p GeneProduct mirbase.mature:mmu-miR-34b-5p
mmu-miR-149-5p GeneProduct mirbase.mature:mmu-miR-149-5p
mmu-miR-362-5p GeneProduct mirbase.mature:mmu-miR-362-5p
mmu-miR-15a-5p GeneProduct mirbase.mature:mmu-miR-15a-5p
mmu-miR-362-5p GeneProduct mirbase.mature:mmu-miR-362-5p
mmu-miR-15a-5p GeneProduct mirbase.mature:mmu-miR-15a-5p
mmu-miR-15a-5p GeneProduct mirbase.mature:mmu-miR-15a-5p
mmu-miR-24-3p GeneProduct mirbase.mature:mmu-miR-24-3p

References

  1. Rieswijk L, Brauers KJJ, Coonen MLJ, van Breda SGJ, Jennen DGJ, Kleinjans JCS. Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes. Mutagenesis. 2015 Nov;30(6):771–84. PubMed Europe PMC Scholia