p38 Mapk signaling pathway (WP294)

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.
last edited


S.Burel, MaintBot, Khanspers, Ddigles, Mkutmon, Egonw, and Eweitz

Cited In


Rattus norvegicus



Pathway Ontology: p38 MAPK signaling pathway


Label Type Compact Identifier
Mapkapk2 GeneProduct ensembl:ENSRNOG00000004726
Grb2 GeneProduct ensembl:ENSRNOG00000003990
Traf2 GeneProduct ensembl:ENSRNOG00000006238
Mapkapk5 GeneProduct ensembl:ENSRNOG00000001345
Hspb1 GeneProduct ensembl:ENSRNOG00000023546
Shc1 GeneProduct ensembl:ENSRNOG00000020657
Map2k6 GeneProduct ensembl:ENSRNOG00000004437
Map3k9 GeneProduct ensembl:ENSRNOG00000007271
Rac1 GeneProduct ensembl:ENSRNOG00000001068
Tgfbr1 GeneProduct ensembl:ENSRNOG00000007036
Mef2d GeneProduct ensembl:ENSRNOG00000031778
Atf2 GeneProduct ensembl:ENSRNOG00000001597
Stat1 GeneProduct ensembl:ENSRNOG00000014079
Creb1 GeneProduct ensembl:ENSRNOG00000013412
Map3k5 GeneProduct ensembl:ENSRNOG00000031700
Mknk1 GeneProduct ensembl:ENSRNOG00000010381
LOC100910771 GeneProduct ensembl:ENSRNOG00000005724
Ripk1 GeneProduct ensembl:ENSRNOG00000017787
Rps6ka5 GeneProduct ensembl:ENSRNOG00000004362
Mapk14 GeneProduct ensembl:ENSRNOG00000000513
Elk1 GeneProduct ensembl:ENSRNOG00000010171
Max GeneProduct ensembl:ENSRNOG00000008049
Mapk14 GeneProduct ensembl:ENSRNOG00000000513
Hras GeneProduct ensembl:ENSRNOG00000016611
Cdc42 GeneProduct ensembl:ENSRNOG00000013536
LOC100911295 GeneProduct ensembl:ENSRNOG00000050978
Apoptosis Pathway wikipathways:WP1290
Pla2g4a GeneProduct ensembl:ENSRNOG00000002657
Map2k4 GeneProduct ensembl:ENSRNOG00000003834
Ddit3 GeneProduct ensembl:ENSRNOG00000006789
Rasgrf1 GeneProduct ensembl:ENSRNOG00000014025
Mapkapk2 GeneProduct ensembl:ENSRNOG00000004726
Tgfb2 GeneProduct ensembl:ENSRNOG00000002418
Daxx GeneProduct ensembl:ENSRNOG00000000477
LOC100912399 GeneProduct ensembl:ENSRNOG00000013177
Myc GeneProduct ensembl:ENSRNOG00000004500
Tradd GeneProduct ensembl:ENSRNOG00000015179


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