G13 signaling pathway (WP298)

The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: [[wikipedia:G12/G13_alpha_subunits|Wikipedia]]
last edited


A.Chow, MaintBot, Thomas, Christine Chichester, Khanspers, Egonw, and Eweitz

Cited In


Mus musculus



Pathway Ontology: G protein mediated signaling pathway via Galpha12/Galpha13 family


Label Type Compact Identifier
Rtkn GeneProduct ncbigene:20166
Pkn1 GeneProduct ncbigene:320795
Cfl2 GeneProduct ncbigene:12632
Rhpn2 GeneProduct ncbigene:52428
Rhoa GeneProduct ncbigene:11848
Pfn1 GeneProduct ncbigene:18643
Arhgef1 GeneProduct ncbigene:16801
Sra1 GeneProduct ncbigene:24068
Gna13 GeneProduct ncbigene:14674
Iqgap2 GeneProduct ncbigene:544963
Iqgap1 GeneProduct ncbigene:29875
Pik3cd GeneProduct ncbigene:18707
Arhgdib GeneProduct ncbigene:11857
Pik3cb GeneProduct ncbigene:74769
Sh3rf1 GeneProduct ncbigene:59009
Limk1 GeneProduct ncbigene:16885
Mybph GeneProduct ncbigene:53311
Rac1 GeneProduct ncbigene:19353
Tnk2 GeneProduct ncbigene:51789
Pak3 GeneProduct ncbigene:18481
Pip4k2a GeneProduct ncbigene:18718
Mapk10 GeneProduct ncbigene:26414
Calm1 GeneProduct ncbigene:12313
Wasl GeneProduct ncbigene:73178
Pik3r2 GeneProduct ncbigene:18709
Ppp1cb GeneProduct ncbigene:19046
Was GeneProduct ncbigene:22376
Map3k4 GeneProduct ncbigene:26407
Myl1 GeneProduct ncbigene:17901
Cit GeneProduct ncbigene:12704
Arhgdig GeneProduct ncbigene:14570
Rock1 GeneProduct ncbigene:19877
Diap1 GeneProduct ncbigene:13367
Pik3ca GeneProduct ncbigene:18706
Cdc42 GeneProduct ncbigene:12540
Rps6kb1 GeneProduct ncbigene:72508
Rock2 GeneProduct ncbigene:19878
Cfl1 GeneProduct ncbigene:12631


  1. Neves SR, Ram PT, Iyengar R. G protein pathways. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia