Focal adhesion (WP306)

Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP306 CPTAC Assay Portal]
last edited

Authors

169.230.77.174, MaintBot, Thomas, Khanspers, AlexanderPico, Egonw, Zari, Dtruong, MirellaKalafati, Ariutta, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: cell adhesion signaling pathway

Participants

Label Type Compact Identifier
Cell Motility Pathway None
Cell Cycle Pathway None
PI3K-AktSignaling Pathway Pathway None
PDGFRA GeneProduct ncbigene:5156
CAPN2 GeneProduct ensembl:ENSG00000162909
RAC1 GeneProduct ncbigene:5879
LAMA1 GeneProduct ncbigene:284217
COL1A1 GeneProduct ncbigene:1277
MAPK3 GeneProduct ensembl:ENSG00000102882
VTN GeneProduct ncbigene:7448
HGF GeneProduct ncbigene:3082
SHC3 GeneProduct ncbigene:53358
THBS3 GeneProduct ncbigene:7059
PIK3R1 GeneProduct ncbigene:5295
FGR GeneProduct ncbigene:2268
BRAF GeneProduct ncbigene:673
ITGB6 GeneProduct ncbigene:3694
ITGA10 GeneProduct ncbigene:8515
COL4A4 GeneProduct ncbigene:1286
THBS1 GeneProduct ncbigene:7057
ILK GeneProduct ncbigene:3611
CCND2 GeneProduct ncbigene:894
THBS4 GeneProduct ncbigene:7060
LAMA2 GeneProduct ncbigene:3908
TNR GeneProduct ncbigene:7143
ITGB8 GeneProduct ncbigene:3696
ROCK1 GeneProduct ncbigene:6093
ITGA6 GeneProduct ncbigene:3655
FYN GeneProduct ncbigene:2534
PPP1R12A GeneProduct ncbigene:4659
TNK2 GeneProduct ncbigene:10188
VAV1 GeneProduct ncbigene:7409
ELK1 GeneProduct ncbigene:2002
PDGFD GeneProduct ncbigene:80310
VEGF GeneProduct ncbigene:7422
MET GeneProduct ncbigene:4233
KDR GeneProduct ncbigene:3791
CRK GeneProduct ncbigene:1398
Catnb GeneProduct ncbigene:1499
ITGA2 GeneProduct ncbigene:3673
RELN GeneProduct ncbigene:5649
ITGA5 GeneProduct ncbigene:3678
MAPK8 GeneProduct ncbigene:5599
PAK3 GeneProduct ncbigene:5063
PARVB GeneProduct ncbigene:29780
ZYX GeneProduct ncbigene:7791
IBSP GeneProduct ncbigene:3381
Wnt SignalingPathway Pathway None
SPP1 GeneProduct ncbigene:6696
PIP3 Metabolite hmdb:HMDB0004249
COL6A2 GeneProduct ncbigene:1292
PTK2 GeneProduct ncbigene:5747
JUN GeneProduct ncbigene:3725
PAK6 GeneProduct ncbigene:56924
ITGAV GeneProduct ncbigene:3685
ITGB1 GeneProduct ncbigene:3688
LAMA5 GeneProduct ncbigene:3911
ITGA4 GeneProduct ncbigene:3676
RAF1 GeneProduct ncbigene:5894
BUB1B-PAK6 GeneProduct ensembl:ENSG00000259288
ITGA2B GeneProduct ncbigene:3674
MAP2K1 GeneProduct ncbigene:5604
LAMB1 GeneProduct ncbigene:3912
FIGF GeneProduct ncbigene:2277
FLT1 GeneProduct ncbigene:2321
PDPK1 GeneProduct ncbigene:5170
ERBB2 GeneProduct ncbigene:2064
EGF GeneProduct ncbigene:1950
CAV1 GeneProduct ncbigene:857
MYLK GeneProduct ncbigene:4638
CAV3 GeneProduct ncbigene:859
MAPK1 GeneProduct ncbigene:5594
CHAD GeneProduct ncbigene:1101
BCL2 GeneProduct ncbigene:596
COMP GeneProduct ncbigene:1311
TNC GeneProduct ncbigene:3371
LAMC3 GeneProduct ncbigene:10319
CRKL GeneProduct ensembl:ENSG00000099942
SHC1 GeneProduct ncbigene:6464
LAMB2 GeneProduct ncbigene:3913
PIK3R3 GeneProduct ensembl:ENSG00000117461
CDC42 GeneProduct ncbigene:998
RAP1B GeneProduct ncbigene:5908
PTEN GeneProduct ncbigene:5728
LAMA3 GeneProduct ncbigene:3909
ACTB GeneProduct ncbigene:60
GRB2 GeneProduct ncbigene:2885
ITGA9 GeneProduct ncbigene:3680
COL4A2 GeneProduct ncbigene:1284
PAK4 GeneProduct ncbigene:10298
CCND1 GeneProduct ncbigene:595
TXK GeneProduct ncbigene:7294
RAC3 GeneProduct ncbigene:5881
TESK2 GeneProduct ncbigene:10420
SRMS GeneProduct ncbigene:6725
COL1A2 GeneProduct ncbigene:1278
MAPK9 GeneProduct ncbigene:5601
ITGA8 GeneProduct ncbigene:8516
VEGFB GeneProduct ncbigene:7423
AKT2 GeneProduct ncbigene:208
COL5A3 GeneProduct ncbigene:50509
PDGFRB GeneProduct ncbigene:5159
PhosphatidylinositolSignaling Pathway None
VASP GeneProduct ncbigene:7408
SOS1 GeneProduct ncbigene:6654
LAMA4 GeneProduct ncbigene:3910
ARHGAP5 GeneProduct ncbigene:394
COL2A1 GeneProduct ncbigene:1280
LAMB3 GeneProduct ncbigene:3914
RAP1A GeneProduct ncbigene:5906
TNK1 GeneProduct ncbigene:8711
COL5A2 GeneProduct ncbigene:1290
DOCK1 GeneProduct ncbigene:1793
ITGB7 GeneProduct ncbigene:3695
COL4A6 GeneProduct ncbigene:1288
XIAP GeneProduct ensembl:ENSG00000101966
PIK3R2 GeneProduct ncbigene:5296
THBS2 GeneProduct ncbigene:7058
HCK GeneProduct ncbigene:3055
PIP2 Metabolite chebi:18348
IGF1 GeneProduct ncbigene:3479
FLNA GeneProduct ncbigene:2316
GSK3B GeneProduct ncbigene:2932
BLK GeneProduct ncbigene:640
LAMC1 GeneProduct ncbigene:3915
FN1 GeneProduct ncbigene:2335
LAMC2 GeneProduct ncbigene:3918
PGF GeneProduct ncbigene:5228
ITGA3 GeneProduct ncbigene:3675
PIK3CA GeneProduct ncbigene:5290
TNN GeneProduct ncbigene:63923
BIRC3 GeneProduct ncbigene:330
CCND3 GeneProduct ncbigene:896
BIRC2 GeneProduct ncbigene:329
AKT1 GeneProduct ncbigene:207
TNXB GeneProduct ncbigene:7148
PAK1 GeneProduct ncbigene:5058
PXN GeneProduct ncbigene:5829
PIP5K1C GeneProduct ncbigene:23396
BAD GeneProduct ncbigene:572
ITGA1 GeneProduct ensembl:ENSG00000213949
IGF1R GeneProduct ncbigene:3480
ACTN4 GeneProduct ensembl:ENSG00000130402
SRC GeneProduct ncbigene:6714
ACTG1 GeneProduct ncbigene:71
HRAS GeneProduct ncbigene:3265
ITGA7 GeneProduct ncbigene:3679
PDGFA GeneProduct ncbigene:5154
BCAR1 GeneProduct ncbigene:9564
VCL GeneProduct ncbigene:7414
CAV2 GeneProduct ncbigene:858
PIK3CB GeneProduct ncbigene:5291
ITGB5 GeneProduct ncbigene:3693
AKT3 GeneProduct ncbigene:10000
STYK1 GeneProduct ncbigene:55359
TLN1 GeneProduct ncbigene:7094
ROCK2 GeneProduct ncbigene:9475
RAC2 GeneProduct ncbigene:5880
PIK3CD GeneProduct ncbigene:5293
PDGFC GeneProduct ncbigene:56034
VWF GeneProduct ncbigene:7450
ITGA11 GeneProduct ncbigene:22801
ITGB4 GeneProduct ncbigene:3691
RAPGEF1 GeneProduct ncbigene:2889
ITGB3 GeneProduct ncbigene:3690
EGFR GeneProduct ncbigene:1956
VEGFC GeneProduct ncbigene:7424
PAK2 GeneProduct ncbigene:5062
DIAPH1 GeneProduct ensembl:ENSG00000131504
PTK6 GeneProduct ncbigene:5753
RHOA GeneProduct ncbigene:387
RASGRF1 GeneProduct ensembl:ENSG00000058335
Regulation of Actin cytoskeleton Pathway None
MYLK2 GeneProduct ncbigene:85366
PDGFB GeneProduct ncbigene:5155
MYL5 GeneProduct ensembl:ENSG00000215375
COL4A1 GeneProduct ncbigene:1282
SHC2 GeneProduct ensembl:ENSG00000129946
SHC4 GeneProduct ensembl:ENSG00000185634
PRKCA GeneProduct ensembl:ENSG00000154229
PRKCB GeneProduct ensembl:ENSG00000166501
PRKCG GeneProduct ensembl:ENSG00000126583
ARHGAP35 GeneProduct ensembl:ENSG00000160007
PPP1R12B GeneProduct ensembl:ENSG00000077157
PPP1R12C GeneProduct ensembl:ENSG00000125503
PPP1CA GeneProduct ensembl:ENSG00000172531
PPP1CB GeneProduct ensembl:ENSG00000213639
PPP1CC GeneProduct ensembl:ENSG00000186298
PPP1CC GeneProduct ensembl:ENSG00000186298
MYL7 GeneProduct ensembl:ENSG00000106631
MYL10 GeneProduct ensembl:ENSG00000106436
MYL12A GeneProduct ensembl:ENSG00000101608
MYL12B GeneProduct ensembl:ENSG00000118680
MYL2 GeneProduct ensembl:ENSG00000111245
MYL9 GeneProduct ensembl:ENSG00000101335
MYLPF GeneProduct ensembl:ENSG00000180209
MYLK3 GeneProduct ensembl:ENSG00000140795
MYLK4 GeneProduct ensembl:ENSG00000145949
ACTN1 GeneProduct ncbigene:87
PARVA GeneProduct ensembl:ENSG00000197702
PARVG GeneProduct ensembl:ENSG00000138964
FLNB GeneProduct ensembl:ENSG00000136068
FLNC GeneProduct ensembl:ENSG00000128591
TLN2 GeneProduct ensembl:ENSG00000171914
MAPK10 GeneProduct ensembl:ENSG00000109339
VAV2 GeneProduct ensembl:ENSG00000160293
VAV3 GeneProduct ensembl:ENSG00000134215

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