SREBF and miR33 in cholesterol and lipid homeostasis (WP3137)

This pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders Näär.
last edited

Authors

Mkutmon and Lindarieswijk

Cited In

Organism

Bos taurus

Communities

Annotations

Pathway Ontology: homeostasis pathway

Participants

Label Type Compact Identifier
SREBF1 GeneProduct ensembl:ENSBTAG00000007884
PPARGC1A GeneProduct ensembl:ENSBTAG00000017024
FASN GeneProduct ensembl:ENSBTAG00000015980
SIRT6 GeneProduct ensembl:ENSBTAG00000019909
HMGCR GeneProduct ensembl:ENSBTAG00000007840
SIRT1 GeneProduct ensembl:ENSBTAG00000014023
MTOR GeneProduct ensembl:ENSBTAG00000015325
SCD GeneProduct ensembl:ENSBTAG00000047957
NR1H3 GeneProduct ensembl:ENSBTAG00000010681
PPARA GeneProduct ensembl:ENSBTAG00000008063
bta-mir-33a Rna ensembl:ENSBTAG00000029975
MED15 GeneProduct ensembl:ENSBTAG00000018048
SREBF2 GeneProduct ensembl:ENSBTAG00000014265
bta-mir-33b Rna ensembl:ENSBTAG00000036437
HMGCS1 GeneProduct ensembl:ENSBTAG00000011839
LDLR GeneProduct ensembl:ENSBTAG00000012314
ABCA1 GeneProduct ensembl:ENSBTAG00000020661
PRKAA1 GeneProduct ensembl:ENSBTAG00000000013

References

  1. Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun Z-Y, Watts JL, et al. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 2006 Aug 10;442(7103):700–4. PubMed Europe PMC Scholia
  2. Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim S-H, Mostoslavsky R, et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 2007 Apr 4;26(7):1913–23. PubMed Europe PMC Scholia
  3. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, et al. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis. EMBO J. 2007 Jul 11;26(13):3169–79. PubMed Europe PMC Scholia
  4. Rodgers JT, Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12861–6. PubMed Europe PMC Scholia
  5. Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature. 2007 Nov 29;450(7170):736–40. PubMed Europe PMC Scholia
  6. Walker AK, Yang F, Jiang K, Ji J-Y, Watts JL, Purushotham A, et al. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 1;24(13):1403–17. PubMed Europe PMC Scholia
  7. Gerin I, Clerbaux L-A, Haumont O, Lanthier N, Das AK, Burant CF, et al. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. J Biol Chem. 2010 Oct 29;285(44):33652–61. PubMed Europe PMC Scholia
  8. Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, et al. MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17321–6. PubMed Europe PMC Scholia