IL-3 signaling pathway (WP319)

Interleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common beta chain, which is shared between all members of this cytokine family. Binding of IL-3 to IL3RA recruits the beta chain to the complex, which activates the JAK/STAT, MAPK and PI 3-kinase signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_15
last edited

Authors

A.Pandey, MaintBot, Christine Chichester, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: interleukin-3 signaling pathway

Participants

Label Type Compact Identifier
IL3 GeneProduct ncbigene:24495
Stat1 GeneProduct ncbigene:25124
Raf1 GeneProduct ncbigene:24703
Stat5a GeneProduct ncbigene:24918
Fcer2 GeneProduct ncbigene:171075
Slc2a1 GeneProduct ncbigene:24778
Kcnip3 GeneProduct ncbigene:65199
Cbl GeneProduct ncbigene:500985
Ptpn6 GeneProduct ncbigene:116689
Atf2 GeneProduct ncbigene:81647
Shc1 GeneProduct ncbigene:85385
MAPK7 GeneProduct ncbigene:114509
Jak2 GeneProduct ncbigene:24514
Pxn GeneProduct ncbigene:360820
Ywhaz GeneProduct ncbigene:25578
Vcl GeneProduct ncbigene:305679
Stat6 GeneProduct ncbigene:362896
Gab1 GeneProduct ncbigene:361388
Tec GeneProduct ncbigene:84492
TYK2 GeneProduct ncbigene:298706
Matk GeneProduct ncbigene:60450
Mapk1 GeneProduct ncbigene:116590
Ptk2 GeneProduct ncbigene:25614
Pik3cd GeneProduct ncbigene:366508
Gata2 GeneProduct ncbigene:25159
Pik3r1 GeneProduct ncbigene:25513
Lyn GeneProduct ncbigene:81515
Bad GeneProduct ncbigene:64639
Bcl2l11 GeneProduct ncbigene:64547
Grb2 GeneProduct ncbigene:81504
Csf2rb GeneProduct ncbigene:171081
Sos1 GeneProduct ncbigene:313845
Slc2a1 GeneProduct ncbigene:24778
Atf1 GeneProduct ncbigene:315305
Vav1 GeneProduct ncbigene:25156
Chek1 GeneProduct ncbigene:140583
Crk GeneProduct ncbigene:54245
Jak1 GeneProduct ncbigene:84598
Stat3 GeneProduct ncbigene:25125
Prkca GeneProduct ncbigene:24680
Id1 GeneProduct ncbigene:25261
PILRB GeneProduct ncbigene:288554
Gnb2l1 GeneProduct ncbigene:83427
IL3 GeneProduct ncbigene:24495
Mapk8 GeneProduct ncbigene:116554
Gab2 GeneProduct ncbigene:84477
Stat5b GeneProduct ncbigene:25126
Prkaca GeneProduct ncbigene:25636
Bmx GeneProduct ncbigene:367786
Csf2rb GeneProduct ncbigene:171081
Lck GeneProduct ncbigene:313050
Ywhab GeneProduct ncbigene:56011
Mapk3 GeneProduct ncbigene:50689
YWHAQ GeneProduct ncbigene:25577
Dnm1 GeneProduct ncbigene:140694
BIRC5 GeneProduct ncbigene:64041
Mapk14 GeneProduct ncbigene:81649
Il3ra GeneProduct ncbigene:246144
Ppp2ca GeneProduct ncbigene:24672
Akt1 GeneProduct ncbigene:24185
Gene Symbol GeneProduct None
Nfkb1 GeneProduct ncbigene:81736
RPS6KB2 GeneProduct ncbigene:361696
Gsk3b GeneProduct ncbigene:84027
Tnfrsf1b GeneProduct ncbigene:156767
Bcl2 GeneProduct ncbigene:24224
Sfpi1 GeneProduct ncbigene:366126
Prkcb GeneProduct ncbigene:25023
Gata1 GeneProduct ncbigene:25172
Mras GeneProduct ncbigene:25482
Kras GeneProduct ncbigene:24525
Bad GeneProduct ncbigene:64639
Mmp9 GeneProduct ncbigene:81687
Ptpn11 GeneProduct ncbigene:25622
Creb1 GeneProduct ncbigene:81646
Rap1a GeneProduct ncbigene:295347
Rara GeneProduct ncbigene:24705
Shc1 GeneProduct ncbigene:85385
Mapk3 GeneProduct ncbigene:50689
Syk GeneProduct ncbigene:25155
Src GeneProduct ncbigene:83805
PIK3CA GeneProduct ncbigene:170911
Bax GeneProduct ncbigene:24887
Mapkapk2 GeneProduct ncbigene:289014
Cish GeneProduct ncbigene:83681
Pik3r2 GeneProduct ncbigene:29741
Mapk9 GeneProduct ncbigene:50658
IL3 GeneProduct ncbigene:24495
Hspb1 GeneProduct ncbigene:24471
Inpp5d GeneProduct ncbigene:54259
Crkl GeneProduct ncbigene:287942
Fes GeneProduct ncbigene:361597
Hras GeneProduct ncbigene:293621
Rac2 GeneProduct ncbigene:366957
RAPGEF1 GeneProduct ncbigene:63881
Selp GeneProduct ncbigene:25651
Gsk3a GeneProduct ncbigene:50686
Foxo1 GeneProduct ncbigene:84482
Prkca GeneProduct ncbigene:24680
Pak1 GeneProduct ncbigene:29431
Il3ra GeneProduct ncbigene:246144
Socs2 GeneProduct ncbigene:84607
Rxra GeneProduct ncbigene:25271
IL3 GeneProduct ncbigene:24495
Map2k1 GeneProduct ncbigene:170851
Hck GeneProduct ncbigene:25734
Nfkb1 GeneProduct ncbigene:81736
Mmp2 GeneProduct ncbigene:81686
Socs3 GeneProduct ncbigene:89829
Rac1 GeneProduct ncbigene:363875
Bcl2l1 GeneProduct ncbigene:24888
CDC42 GeneProduct ncbigene:64465
Fyn GeneProduct ncbigene:25150

References