Overview of nanoparticle effects (WP3287)

This pathway is giving a summary of currently known nanoparticle effects on cells and organisms. Although there is currently no nanoparticle-specific effect known, there is a cascade of effects triggered if cells or organisms are exposed to nanoparticles: The most abundantly observed event is oxidative stress which causes DNA damage, protein and lipid oxidation, and cell death. The mere overload of nanoparticles in the vesicular system leads to cytoskeleton and cell adhesion problems and interfere with the cell's autophagic system. Some specific nanoparticles are reported to interfere with the cell membrane, others stimulate the blood coagulation system. The release of metal ions from specific nanoparticles challenges the metal disposal system of the cell.
last edited

Authors

Fehrhart, Mkutmon, Lindarieswijk, Egonw, MaintBot, and Eweitz

Cited In

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Organism

Homo sapiens

Communities

Adverse Outcome Pathways Nanomaterials Pathways

Annotations

Pathway Ontology: nanomaterial response pathway

Participants

Label Type Compact Identifier
Oxidative stress Pathway wikipathways:WP408
AKT GeneProduct ensembl:ENSG00000117020
Prostaglandin pathway Pathway wikipathways:WP98
Angiogenesis Pathway wikipathways:WP1539
ferritin GeneProduct pfam:PF00210
C-reactive protein GeneProduct ensembl:ENSG00000132693
COX2 (PTGS2) GeneProduct ensembl:ENSG00000073756
Glutathione Metabolite chebi:16856
DNA damage response Pathway wikipathways:WP707
TNF-a Signaling Pathway wikipathways:WP231
Cytoskeleton Pathway wikipathways:WP51
PI3K GeneProduct ensembl:ENSG00000171608
Il-6 signaling Pathway wikipathways:WP364
Integrin GeneProduct ensembl:ENSG00000156886
HMOX1 GeneProduct ensembl:ENSG00000100292
Autophagic cell death Pathway wikipathways:WP2509
Cell cycle Pathway wikipathways:WP179
FAK (PTK2) GeneProduct ensembl:ENSG00000169398
Nanoparticle Metabolite chebi:50803
Immune systemup or down regulation Pathway wikipathways:WP2783
Necrosis Pathway wikipathways:WP2513
Cell adhesion Pathway wikipathways:WP306
Blood coagulation Pathway wikipathways:WP558
Inflammation Pathway wikipathways:WP453
Metallothionein GeneProduct pfam:PF00131
Prostaglandin Metabolite chebi:26333
Necroptosis Pathway wikipathways:WP2513
Differentiation Pathway wikipathways:WP2848
COX1 (PTGS1) GeneProduct ensembl:ENSG00000095303
Actin GeneProduct pfam:PF00022
P-cadherin GeneProduct ensembl:ENSG00000062038
Apoptosis Pathway wikipathways:WP2507
fibronectin GeneProduct ensembl:ENSG00000115414
collagen IV GeneProduct ensembl:ENSG00000187498
NF-kB GeneProduct ensembl:ENSG00000170322
Bax GeneProduct ensembl:ENSG00000087088
IL-6 GeneProduct ensembl:ENSG00000136244
Il-8 GeneProduct ensembl:ENSG00000169429
Bcl-2 GeneProduct ensembl:ENSG00000171791
TNF GeneProduct ensembl:ENSG00000232810
cyclin D3 GeneProduct ensembl:ENSG00000112576
laminin GeneProduct ensembl:ENSG00000053747

References

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