let-7 inhibition of ES cell reprogramming (WP3299)

Four transcription factors (OCT4, KLF4, SOX2, and c-MYC) reprogram adult cells into stem cells. MicroRNA let-7 is a barrier to reprogramming that inhibits LIN-41, a strong reprogramming factor that is expressed in pluripotent embryonic stem cells. LIN-41 inhibits the transcription factor EGR1, which promotes cell differentiation and is another barrier to reprogramming. (Description from Worringer et al)
last edited


Khanspers and Jmelius

Cited In


Homo sapiens



Pathway Ontology: regulatory pathway


Label Type Compact Identifier
c-MYC GeneProduct ensembl:ENSG00000136997
LIN-41 GeneProduct ensembl:ENSG00000206557
MIRLET7A1 GeneProduct ensembl:ENSG00000199165
EGR1 GeneProduct ensembl:ENSG00000120738
SOX2 GeneProduct ensembl:ENSG00000181449
KLF4 GeneProduct ensembl:ENSG00000136826
OCT4 GeneProduct ncbigene:5460
MIRLET7A2 GeneProduct ensembl:ENSG00000198975
MIRLET7A3 GeneProduct ensembl:ENSG00000198986
MIRLET7C GeneProduct ensembl:ENSG00000199030
MIRLET7D GeneProduct ensembl:ENSG00000199133
MIRLET7E GeneProduct ensembl:ENSG00000198972
MIRLET7F1 GeneProduct ensembl:ENSG00000199072
MIRLET7F2 GeneProduct ensembl:ENSG00000208012
MIRLET7G GeneProduct ensembl:ENSG00000199150
MIRLET7I GeneProduct ensembl:ENSG00000199179


  1. Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, et al. The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes. Cell Stem Cell. 2014 Jan 2;14(1):40–52. PubMed Europe PMC Scholia