MFAP5-mediated ovarian cancer cell motility and invasiveness (WP3301)

A graphical summary of the molecular signaling events involved in MFAP5-mediated ovarian cancer cell motility and invasiveness. Based on figure 6c in [https://www.ncbi.nlm.nih.gov/pubmed/25277212 Leung et al]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3301 CPTAC Assay Portal]
last edited

Authors

Khanspers, Elisa, AMTan, MaintBot, and Fehrhart

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Disease Ontology: ovarian cancer disease of cellular proliferation

Pathway Ontology: disease pathway cancer pathway

Participants

Label Type Compact Identifier
Ca2+ Metabolite hmdb:HMDB0000464
Troponin C GeneProduct ensembl:ENSG00000114854
CREB1 GeneProduct ensembl:ENSG00000118260
IP3 Metabolite cas:85166-31-0
MFAP5 GeneProduct ensembl:ENSG00000197614
ITGB3 GeneProduct ensembl:ENSG00000259207
TNNC1 GeneProduct ensembl:ENSG00000114854
RYR3 GeneProduct ensembl:ENSG00000198838
DAG Metabolite hmdb:HMDB0007098
PLCG1 GeneProduct ensembl:ENSG00000124181
PIP2 Metabolite cas:245126-95-8
FAK GeneProduct ensembl:ENSG00000169398
PRKCQ GeneProduct ensembl:ENSG00000065675
ITPR3 GeneProduct ensembl:ENSG00000096433
JUN GeneProduct ensembl:ENSG00000177606
ITGAV GeneProduct ensembl:ENSG00000138448
ERK2 GeneProduct ensembl:ENSG00000100030
Ca2+ Metabolite hmdb:HMDB0000464
Ca2+ Metabolite hmdb:HMDB0000464
Ca2+ Metabolite hmdb:HMDB0000464
Ca2+ Metabolite hmdb:HMDB0000464
Ca2+ Metabolite hmdb:HMDB0000464
FAK GeneProduct ensembl:ENSG00000169398
PRKCQ GeneProduct ensembl:ENSG00000065675
PLCG1 GeneProduct ensembl:ENSG00000124181
Troponin C GeneProduct ensembl:ENSG00000114854
CREB1 GeneProduct ensembl:ENSG00000118260
CREB1 GeneProduct ensembl:ENSG00000118260
ERK2 GeneProduct ensembl:ENSG00000100030
Ca2+ Metabolite hmdb:HMDB0000464
Ca2+ Metabolite hmdb:HMDB0000464
JUN GeneProduct ensembl:ENSG00000177606
ERK1 GeneProduct ensembl:ENSG00000102882
ERK1 GeneProduct ensembl:ENSG00000102882

References

  1. Leung CS, Yeung T-L, Yip K-P, Pradeep S, Balasubramanian L, Liu J, et al. Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential. Nat Commun. 2014 Oct 3;5:5092. PubMed Europe PMC Scholia