GPCRs, class B secretin-like (WP334)

This pathway was created using the GPCRDB (Horn et al., 1998), (originally at The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.
last edited


Nsalomonis, MaintBot, AlexanderPico, BruceConklin, Khanspers, Egonw, and Eweitz

Cited In


Homo sapiens



Pathway Ontology: G protein mediated signaling pathway


Label Type Compact Identifier
ELTD1 GeneProduct ncbigene:64123
PTHR2 GeneProduct ncbigene:5746
PTHR1 GeneProduct ncbigene:5745
CD97 GeneProduct ncbigene:976
GCGR GeneProduct ncbigene:2642
GPR64 GeneProduct ncbigene:10149
GIPR GeneProduct ncbigene:2696
EMR1 GeneProduct ncbigene:2015
CALCR GeneProduct ncbigene:799
GHRHR GeneProduct ncbigene:2692
LPHN3 GeneProduct ncbigene:23284
CRHR1 GeneProduct ncbigene:1394
SCTR GeneProduct ncbigene:6344
CRHR2 GeneProduct ncbigene:1395
VIPR1 GeneProduct ncbigene:7433
CD97 GeneProduct ncbigene:976
LPHN1 GeneProduct ncbigene:22859
LPHN2 GeneProduct ncbigene:23266
GLP1R GeneProduct ncbigene:2740
GLP2R GeneProduct ncbigene:9340
EMR2 GeneProduct ncbigene:30817
ADCYAP1R1 GeneProduct ncbigene:117
VIPR2 GeneProduct ncbigene:7434
CALCRL GeneProduct ncbigene:10203


  1. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, et al. GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res. 1998 Jan 1;26(1):275–9. PubMed Europe PMC Scholia
  2. Karchin R, Karplus K, Haussler D. Classifying G-protein coupled receptors with support vector machines. Bioinformatics. 2002 Jan;18(1):147–59. PubMed Europe PMC Scholia