Initiation of transcription and translation elongation at the HIV-1 LTR (WP3414)

Following cellular activation or drug treatment, NFAT and NF-kB translocate to the nucleus and bind sites at the HIV-1 LTR. NFAT and NF-kB recruit p300/CBP to the LTR, resulting in acetylation of histone tails and transcriptional activation. In the case of NF-kB, proteosomal degradation of IkBa permits NF-kB translocation and displacement of the p50 homodimers. This is followed by Tat- dependent elongation in which Tat recruits the P-TEFb complex to TAR. Cdk9 phosphorylates the CTD of RNA Pol II, resulting in increased processivity. P-TEFb phosphorylates DSIF and NELF, resulting in removal of NELF from Pol II and converting DSIF into a positive elongation factor, thereby promoting productive elongation. Data nodes in blue represent HIV proteins. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3414 CPTAC Assay Portal]
last edited

Authors

Khanspers, MaintBot, and AMTan

Cited In

Organism

Homo sapiens

Communities

Annotations

Disease Ontology: human immunodeficiency virus infectious disease

Participants

Label Type Compact Identifier
NFATC4 GeneProduct ensembl:ENSG00000100968
NFATC3 GeneProduct ensembl:ENSG00000072736
NFATC2 GeneProduct ensembl:ENSG00000101096
Histones GeneProduct None
SUPT4H1 GeneProduct ensembl:ENSG00000213246
CDK9 GeneProduct ensembl:ENSG00000136807
HDAC1 GeneProduct ensembl:ENSG00000116478
HDAC GeneProduct None
RNA Pol II GeneProduct None
PPP3R1 GeneProduct ensembl:ENSG00000221823
NELFB GeneProduct ensembl:ENSG00000188986
SP1 GeneProduct ensembl:ENSG00000185591
Tat GeneProduct None
HEXIM1 GeneProduct ensembl:ENSG00000186834
PPP3CA GeneProduct ensembl:ENSG00000138814
SUPT5H GeneProduct ensembl:ENSG00000196235
PPP3CC GeneProduct ensembl:ENSG00000120910
HMBA Metabolite hmdb:HMDB0041901
PPP3CB GeneProduct ensembl:ENSG00000107758
p300 GeneProduct ensembl:ENSG00000100393
CycT1 GeneProduct ensembl:ENSG00000129315
PPP3R2 GeneProduct ensembl:ENSG00000188386
CBP GeneProduct ensembl:ENSG00000005339
NELFA GeneProduct ensembl:ENSG00000185049
IKBA GeneProduct ensembl:ENSG00000100906
NFATC1 GeneProduct ensembl:ENSG00000131196
RELA GeneProduct ensembl:ENSG00000173039
NFATC4 GeneProduct ensembl:ENSG00000100968
Prostratin Metabolite chemspider:399975
NFATC3 GeneProduct ensembl:ENSG00000072736
Ubiquitin GeneProduct None
NFATC2 GeneProduct ensembl:ENSG00000101096
NFATC1 GeneProduct ensembl:ENSG00000131196
p50 GeneProduct ensembl:ENSG00000109320
NFATC4 GeneProduct ensembl:ENSG00000100968
NFATC3 GeneProduct ensembl:ENSG00000072736
NFATC2 GeneProduct ensembl:ENSG00000101096
NFATC1 GeneProduct ensembl:ENSG00000131196
IKBA GeneProduct ensembl:ENSG00000100906
RELA GeneProduct ensembl:ENSG00000173039
p50 GeneProduct ensembl:ENSG00000109320
RELA GeneProduct ensembl:ENSG00000173039
p50 GeneProduct ensembl:ENSG00000109320
RELA GeneProduct ensembl:ENSG00000173039
p50 GeneProduct ensembl:ENSG00000109320
RELA GeneProduct ensembl:ENSG00000173039
p50 GeneProduct ensembl:ENSG00000109320
NFATC4 GeneProduct ensembl:ENSG00000100968
NFATC3 GeneProduct ensembl:ENSG00000072736
NFATC2 GeneProduct ensembl:ENSG00000101096
NFATC1 GeneProduct ensembl:ENSG00000131196
p50 GeneProduct ensembl:ENSG00000109320
p50 GeneProduct ensembl:ENSG00000109320
CBP GeneProduct ensembl:ENSG00000005339
p300 GeneProduct ensembl:ENSG00000100393
Histones GeneProduct None
CDK9 GeneProduct ensembl:ENSG00000136807
CycT1 GeneProduct ensembl:ENSG00000129315
Tat GeneProduct None
Tat GeneProduct None
NELFCD GeneProduct ensembl:ENSG00000101158
NELFE GeneProduct ncbigene:7936
CDK9 GeneProduct ensembl:ENSG00000136807
CycT1 GeneProduct ensembl:ENSG00000129315
Tat GeneProduct None
SP1 GeneProduct ensembl:ENSG00000185591
SP1 GeneProduct ensembl:ENSG00000185591
HDAC2 GeneProduct ensembl:ENSG00000196591
HDAC3 GeneProduct ensembl:ENSG00000171720
HDAC4 GeneProduct ensembl:ENSG00000068024
HDAC5 GeneProduct ensembl:ENSG00000108840
HDAC7 GeneProduct ensembl:ENSG00000061273
HDAC8 GeneProduct ncbigene:55869
HDAC9 GeneProduct ensembl:ENSG00000048052

References

  1. Ruelas DS, Greene WC. An integrated overview of HIV-1 latency. Cell. 2013 Oct 24;155(3):519–29. PubMed Europe PMC Scholia