G1 to S cell cycle control (WP348)

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&
last edited

Authors

A.C.Zambon, MaintBot, Khanspers, Christine Chichester, and Mkutmon

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: G1/S DNA damage checkpoint pathway cell cycle checkpoint pathway

Participants

Label Type Compact Identifier
Rb1 GeneProduct ensembl:ENSRNOG00000016029
E2f2 GeneProduct ensembl:ENSRNOG00000047741
E2f1 GeneProduct ensembl:ENSRNOG00000016708
Pole GeneProduct ensembl:ENSRNOG00000037449
Cdkn1b GeneProduct ensembl:ENSRNOG00000007249
Cdk6 GeneProduct ensembl:ENSRNOG00000009258
Pcna GeneProduct ensembl:ENSRNOG00000021264
Cdk4 GeneProduct ensembl:ENSRNOG00000025602
Cdkn1a GeneProduct ensembl:ENSRNOG00000000521
Cdc45 GeneProduct ensembl:ENSRNOG00000050071
CDKN2A GeneProduct None
Cdk1 GeneProduct ensembl:ENSRNOG00000000632
CDK GeneProduct None
E2f GeneProduct None
Tp53 GeneProduct ensembl:ENSRNOG00000010756
Prim2 GeneProduct ensembl:ENSRNOG00000012486
Cdkn1c GeneProduct ensembl:ENSRNOG00000059500
Ccnd2 GeneProduct ensembl:ENSRNOG00000057710
E2f5 GeneProduct ensembl:ENSRNOG00000010760
Ccne1 GeneProduct ensembl:ENSRNOG00000014786
CDK GeneProduct None
Creb3l4 GeneProduct ensembl:ENSRNOG00000023493
Cdkn2b GeneProduct ensembl:ENSRNOG00000006735
Mdm2 GeneProduct ensembl:ENSRNOG00000006304
Cdk7 GeneProduct ensembl:ENSRNOG00000018510
Ccng2 GeneProduct ensembl:ENSRNOG00000002089
Rpa2 GeneProduct ensembl:ENSRNOG00000013005
Cdk4 GeneProduct ensembl:ENSRNOG00000025602
Cdk2 GeneProduct ensembl:ENSRNOG00000006469
E2f4 GeneProduct ensembl:ENSRNOG00000015708
Tp53 GeneProduct ensembl:ENSRNOG00000010756
CDKN2D GeneProduct None
Cdk7 GeneProduct ensembl:ENSRNOG00000018510
Creb3 GeneProduct ensembl:ENSRNOG00000016452
Creb3l3 GeneProduct ensembl:ENSRNOG00000032202
Myt1 GeneProduct ensembl:ENSRNOG00000017346
Tfdp2 GeneProduct ensembl:ENSRNOG00000011241
Ccnb1 GeneProduct ensembl:ENSRNOG00000058539
Rb1 GeneProduct ensembl:ENSRNOG00000016029
Ccnd3 GeneProduct ensembl:ENSRNOG00000050258
Ccnd1 GeneProduct ensembl:ENSRNOG00000020918
Ccnh GeneProduct ensembl:ENSRNOG00000031656
Myc GeneProduct ensembl:ENSRNOG00000004500
LOC100362927 GeneProduct ensembl:ENSRNOG00000037481
Mcm4 GeneProduct ensembl:ENSRNOG00000001833
Mcm3 GeneProduct ensembl:ENSRNOG00000012543
Atf6b GeneProduct ensembl:ENSRNOG00000000431
Orc1 GeneProduct ensembl:ENSRNOG00000008841
Rb1 GeneProduct ensembl:ENSRNOG00000016029
Mcm6 GeneProduct ensembl:ENSRNOG00000003703
Mcm7 GeneProduct ensembl:ENSRNOG00000001349
Mcm2 GeneProduct ensembl:ENSRNOG00000016316
Orc3 GeneProduct ensembl:ENSRNOG00000008314
Cdkn2c GeneProduct ensembl:ENSRNOG00000008956
Pole2 GeneProduct ensembl:ENSRNOG00000004242
Mnat1 GeneProduct ensembl:ENSRNOG00000007267
Orc6 GeneProduct ensembl:ENSRNOG00000024043
Cdk2 GeneProduct ensembl:ENSRNOG00000006469
Mcm5 GeneProduct ensembl:ENSRNOG00000014336
E2f6 GeneProduct ensembl:ENSRNOG00000004449
Orc2 GeneProduct ensembl:ENSRNOG00000012558
E2f3 GeneProduct ensembl:ENSRNOG00000029273
Tfdp1 GeneProduct ensembl:ENSRNOG00000019222
Cdk6 GeneProduct ensembl:ENSRNOG00000009258
Rpa1 GeneProduct ensembl:ENSRNOG00000003123
Creb1 GeneProduct ensembl:ENSRNOG00000013412
Rbl1 GeneProduct ensembl:ENSRNOG00000006921
Tfdp1 GeneProduct ensembl:ENSRNOG00000019222
Wee1 GeneProduct ensembl:ENSRNOG00000010017
Atm GeneProduct ensembl:ENSRNOG00000029773
Creb3l1 GeneProduct ensembl:ENSRNOG00000005413
Gadd45a GeneProduct ensembl:ENSRNOG00000005615
Pola2 GeneProduct ensembl:ENSRNOG00000020906
Orc4 GeneProduct ensembl:ENSRNOG00000005021
Ccne1 GeneProduct ensembl:ENSRNOG00000014786
Prim1 GeneProduct ensembl:ENSRNOG00000031993
Cdc25a GeneProduct ensembl:ENSRNOG00000020737
Ccne1 GeneProduct ensembl:ENSRNOG00000014786
E2f GeneProduct None
Ccna1 GeneProduct ensembl:ENSRNOG00000014052
Orc5 GeneProduct ensembl:ENSRNOG00000011519
Ccne2 GeneProduct ensembl:ENSRNOG00000008055

References

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA. GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. J Invest Dermatol. 2002 Jul;119(1):22–6. PubMed Europe PMC Scholia