IL-1 signaling pathway (WP355)

The interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor, IL1R2. Upon binding to the ligands, interleukin-1 alpha or beta, IL1R1 interacts with IL-1 receptor accessory protein (IL1RAP) to activate the MAPK/JNK signaling modules. The MAPK pathway leads to activation of NFkB complex. As both IL-1 and TNF alpha stimulate the MAPK signaling module and activate NFkB, they are synergistic and complement each other's activity. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_13
last edited

Authors

A.Pandey, MaintBot, Christine Chichester, Egonw, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: interleukin-1 signaling pathway

Participants

Label Type Compact Identifier
PELI1 GeneProduct ncbigene:305549
RELA GeneProduct ncbigene:309165
TOLLIP GeneProduct ncbigene:361677
MAP3K7 GeneProduct ncbigene:313121
Traf6 GeneProduct ncbigene:311245
Traf6 GeneProduct ncbigene:311245
Gene Symbol GeneProduct None
Il1a GeneProduct ncbigene:24493
Irak1 GeneProduct ncbigene:363520
Il1a GeneProduct ncbigene:24493
MAP3K7 GeneProduct ncbigene:313121
MAPK1 GeneProduct ncbigene:116590
Il1r2 GeneProduct ncbigene:117022
MAP3K7IP2 GeneProduct None
NFKB1 GeneProduct ncbigene:81736
Traf6 GeneProduct ncbigene:311245
Irak4 GeneProduct ncbigene:300177
MAP3K14 GeneProduct ncbigene:360640
Il1rap GeneProduct ncbigene:25466
PELI1 GeneProduct ncbigene:305549
MAP2K1 GeneProduct ncbigene:170851
MAP3K7IP2 GeneProduct None
Irak1 GeneProduct ncbigene:363520
Traf6 GeneProduct ncbigene:311245
Irak1 GeneProduct ncbigene:363520
Il1a GeneProduct ncbigene:24493
NFKBIA GeneProduct ncbigene:25493
Traf6 GeneProduct ncbigene:311245
Il1b GeneProduct ncbigene:24494
Ptpns1 GeneProduct ncbigene:25528
CASP1 GeneProduct ncbigene:25166
TOLLIP GeneProduct ncbigene:361677
MAP3K7IP2 GeneProduct None
Il1a GeneProduct ncbigene:24493
MAPK3 GeneProduct ncbigene:50689
MAP3K7IP2 GeneProduct None
Il1r1 GeneProduct ncbigene:25663
PTPN11 GeneProduct ncbigene:25622
MAPK8 GeneProduct ncbigene:116554
PTPN11 GeneProduct ncbigene:25622
Il1rn GeneProduct ncbigene:60582
IRAK4 GeneProduct ncbigene:300177
MAP3K7 GeneProduct ncbigene:313121
MAP3K7 GeneProduct ncbigene:313121
Il1r2 GeneProduct ncbigene:117022
Il1b GeneProduct ncbigene:24494
MAP3K7 GeneProduct ncbigene:313121
Myd88 GeneProduct ncbigene:301059
CAPNS1 GeneProduct ncbigene:29156
Traf6 GeneProduct ncbigene:311245
PRKCZ GeneProduct ncbigene:25522
RELA GeneProduct ncbigene:309165
Il1r1 GeneProduct ncbigene:25663
Il1b GeneProduct ncbigene:24494
PLCG1 GeneProduct ncbigene:25738
MAP3K7IP2 GeneProduct None
CAPN1 GeneProduct ncbigene:29153
MAPK1 GeneProduct ncbigene:116590
Irak1 GeneProduct ncbigene:363520
Irak1 GeneProduct ncbigene:363520
Irak2 GeneProduct ncbigene:362418
CHUK GeneProduct ncbigene:309361
IKBKAP GeneProduct ncbigene:140934
Il1rap GeneProduct ncbigene:25466
MAP3K7IP1 GeneProduct ncbigene:315139
SQSTM1 GeneProduct ncbigene:113894
MAP3K7IP1 GeneProduct ncbigene:315139
CHUK GeneProduct ncbigene:309361
MAP3K7 GeneProduct ncbigene:313121
MAP3K7IP2 GeneProduct None
NFKBIA GeneProduct ncbigene:25493
Il1r2 GeneProduct ncbigene:117022
AKT1 GeneProduct ncbigene:24185
MAP3K14 GeneProduct ncbigene:360640
IRAK4 GeneProduct ncbigene:300177
MAP3K7IP1 GeneProduct ncbigene:315139
Ptpns1 GeneProduct ncbigene:25528
NFKBIB GeneProduct ncbigene:81525
IRAK3 GeneProduct ncbigene:314870
Il1r1 GeneProduct ncbigene:25663
Irak1 GeneProduct ncbigene:363520
Il1b GeneProduct ncbigene:24494
Il1rn GeneProduct ncbigene:60582

References