Fatty acid biosynthesis (WP357)

Fatty acid synthesis is the creation of fatty acids from acetyl-CoA and NADPH through the action of enzymes called fatty acid synthases. This process takes place in the cytoplasm of the cell. Most of the acetyl-CoA which is converted into fatty acids is derived from carbohydrates via the glycolytic pathway. Source: [https://en.wikipedia.org/wiki/Fatty_acid_synthesis Wikipedia] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP357 CPTAC Assay Portal]
last edited


Kdahlquist, MaintBot, Michiel, AlexanderPico, Evelo, Bassetfrog, Jildau, MartijnVanIersel, Egonw, Mkutmon, Fehrhart, Khanspers, DeSl, and Eweitz

Cited In


Homo sapiens



Pathway Ontology: fatty acid biosynthetic pathway


Label Type Compact Identifier
3-L-Hydroxyacyl-CoA Metabolite chebi:57318
Acetyl-synthase Protein ensembl:ENSG00000131069
Acetyl-ACP Metabolite wikidata:Q59811305
beta-hydroxybutyryl Metabolite None
Crotonoyl-ACP Metabolite kegg.compound:C04618
Oxaloacetate Metabolite chebi:30744
Fatty acyl CoA Metabolite None
Palmitate Metabolite chemspider:440215
Malonyl-ACP Metabolite kegg.compound:C01209
trans-delta2-enoyl-CoA Metabolite None
Butyryl-ACP Metabolite chebi:3247
Acetoacetyl-ACP Metabolite chebi:2393
Palmitoyl-ACP Metabolite kegg.compound:C16520
TCA Cycle Pathway wikipathways:WP78
Citrate Metabolite chemspider:29081
pyruvate Metabolite chebi:15361
Long-Chain fatty acid Metabolite chebi:15904
3-ketoacyl-CoA Metabolite chebi:57347
FASN GeneProduct ncbigene:2194
Malonyl-CoA Metabolite cas:524-14-1
ECHS1 GeneProduct ncbigene:1892
ACSL5 GeneProduct ncbigene:51703
FASN GeneProduct ncbigene:2194
PECR GeneProduct ncbigene:55825
ECHDC2 GeneProduct ncbigene:55268
ACACA GeneProduct ncbigene:31
ECHDC1 GeneProduct ncbigene:55862
ACSL4 GeneProduct ncbigene:2182
Acetyl-CoA Metabolite chebi:15351
FASN GeneProduct ncbigene:2194
SCD GeneProduct ncbigene:6319
ACAS2 GeneProduct ncbigene:55902
FASN GeneProduct ncbigene:2194
ECHDC3 GeneProduct ncbigene:79746
FASN GeneProduct ncbigene:2194
ACLY GeneProduct ncbigene:47
FASN GeneProduct ncbigene:2194
ACSL3 GeneProduct ncbigene:2181
HADHSC GeneProduct ncbigene:3033
FASN GeneProduct ncbigene:2194
ACACB GeneProduct ncbigene:32
ACSL1 GeneProduct ncbigene:2180
PC GeneProduct ncbigene:5091
ACAA2 GeneProduct ncbigene:10449
FASN GeneProduct ncbigene:2194
MECR GeneProduct ncbigene:51102
Triacylglyceride Synthesis pathway Pathway wikipathways:WP325
DECR1 GeneProduct ncbigene:1666
Acyl-CoA (n+2) Metabolite cas:9029-97-4
ACSL6 GeneProduct ncbigene:23305
ECH1 GeneProduct ncbigene:1891


  1. Weiss L, Hoffmann GE, Schreiber R, Andres H, Fuchs E, Körber E, et al. Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Biol Chem Hoppe Seyler. 1986 Sep;367(9):905–12. PubMed Europe PMC Scholia