MAPK signaling pathway (WP358)

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010
last edited

Authors

S.Burel, MaintBot, Khanspers, Ddigles, Mkutmon, Egonw, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: mitogen activated protein kinase signaling pathway mitogen activated protein kinase signaling pathway

Participants

Label Type Compact Identifier
Traf6 GeneProduct ensembl:ENSRNOG00000004639
Mef2c GeneProduct ensembl:ENSRNOG00000033134
Srf GeneProduct ensembl:ENSRNOG00000018232
Rps6ka3 GeneProduct ensembl:ENSRNOG00000006632
Map2k3 GeneProduct ensembl:ENSRNOG00000049132
Elk4 GeneProduct ensembl:ENSRNOG00000007887
Rap1a GeneProduct ensembl:ENSRNOG00000032463
Crk GeneProduct ensembl:ENSRNOG00000025792
Il1a GeneProduct ensembl:ENSRNOG00000004575
Pdgfb GeneProduct ensembl:ENSRNOG00000017197
Akt3 GeneProduct ensembl:ENSRNOG00000021497
Ecsit GeneProduct ensembl:ENSRNOG00000014128
Map3k13 GeneProduct ensembl:ENSRNOG00000025423
Rasgrp4 GeneProduct ensembl:ENSRNOG00000033744
LOC100910771 GeneProduct ensembl:ENSRNOG00000005724
Mapk9 GeneProduct ensembl:ENSRNOG00000002823
Grb2 GeneProduct ensembl:ENSRNOG00000003990
Mknk1 GeneProduct ensembl:ENSRNOG00000010381
Dusp1 GeneProduct ensembl:ENSRNOG00000003977
Stmn1 GeneProduct ensembl:ENSRNOG00000016810
Elk1 GeneProduct ensembl:ENSRNOG00000010171
Egfr GeneProduct ensembl:ENSRNOG00000004332
Ppp3cb GeneProduct ensembl:ENSRNOG00000054782
Ppp3cc GeneProduct ensembl:ENSRNOG00000009745
Map4k1 GeneProduct ensembl:ENSRNOG00000020505
Nfatc1 GeneProduct ensembl:ENSRNOG00000017146
Arrb2 GeneProduct ensembl:ENSRNOG00000019308
Mapt GeneProduct ensembl:ENSRNOG00000005133
Rasgrp1 GeneProduct ensembl:ENSRNOG00000005404
Rap1b GeneProduct ensembl:ENSRNOG00000007048
Cd14 GeneProduct ensembl:ENSRNOG00000017819
Ikbkg GeneProduct ensembl:ENSRNOG00000060936
Bdnf GeneProduct ensembl:ENSRNOG00000047466
Daxx GeneProduct ensembl:ENSRNOG00000000477
Mapk10 GeneProduct ensembl:ENSRNOG00000002079
LOC103694380 GeneProduct ensembl:ENSRNOG00000000837
Mos GeneProduct ensembl:ENSRNOG00000008567
Stk4 GeneProduct ensembl:ENSRNOG00000013529
Mapk14 GeneProduct ensembl:ENSRNOG00000000513
Ikbkb GeneProduct ensembl:ENSRNOG00000019073
Arrb1 GeneProduct ensembl:ENSRNOG00000030404
Lrrk2 GeneProduct ensembl:ENSRNOG00000004048
Casp3 GeneProduct ensembl:ENSRNOG00000010475
Flna GeneProduct ensembl:ENSRNOG00000054890
PRKACA GeneProduct None
Mapkapk2 GeneProduct ensembl:ENSRNOG00000004726
Tnfrsf1a GeneProduct ensembl:ENSRNOG00000031312
Map3k14 GeneProduct ensembl:ENSRNOG00000003278
Hspb1 GeneProduct ensembl:ENSRNOG00000023546
Map3k20 GeneProduct ensembl:ENSRNOG00000001515
Gna12 GeneProduct ensembl:ENSRNOG00000001235
Tgfb1 GeneProduct ensembl:ENSRNOG00000020652
LOC100912399 GeneProduct ensembl:ENSRNOG00000013177
Map3k2 GeneProduct ensembl:ENSRNOG00000014089
Max GeneProduct ensembl:ENSRNOG00000008049
Dusp10 GeneProduct ensembl:ENSRNOG00000004003
RASGRF2 GeneProduct ensembl:ENSRNOG00000056151
Map4k4 GeneProduct ensembl:ENSRNOG00000014013
Pdgfrb GeneProduct ensembl:ENSRNOG00000018461
Tab1 GeneProduct ensembl:ENSRNOG00000017285
Map3k4 GeneProduct ensembl:ENSRNOG00000017419
Gadd45a GeneProduct ensembl:ENSRNOG00000005615
Wnt signaling pathway Pathway wikipathways:WP428
Map2k5 GeneProduct ensembl:ENSRNOG00000007926
Cdc25b GeneProduct ensembl:ENSRNOG00000021248
Il1r1 GeneProduct ensembl:ENSRNOG00000014504
Rac2 GeneProduct ensembl:ENSRNOG00000007350
Prkcd GeneProduct ensembl:ENSRNOG00000016346
Ppp5c GeneProduct ensembl:ENSRNOG00000016907
Map2k1 GeneProduct ensembl:ENSRNOG00000010176
Rac1 GeneProduct ensembl:ENSRNOG00000001068
Ptpn7 GeneProduct ensembl:ENSRNOG00000005807
Il1r2 GeneProduct ensembl:ENSRNOG00000014378
Tab2 GeneProduct ensembl:ENSRNOG00000016054
Tgfbr1 GeneProduct ensembl:ENSRNOG00000007036
Mapk1 GeneProduct ensembl:ENSRNOG00000001849
Ptprr GeneProduct ensembl:ENSRNOG00000004483
Ptpn5 GeneProduct ensembl:ENSRNOG00000013981
Pla2g4d GeneProduct ensembl:ENSRNOG00000037231
Braf GeneProduct ensembl:ENSRNOG00000010957
Ntrk1 GeneProduct ensembl:ENSRNOG00000013953
Atf2 GeneProduct ensembl:ENSRNOG00000001597
Map2k4 GeneProduct ensembl:ENSRNOG00000003834
LPS Metabolite chebi:16412
Fos GeneProduct ensembl:ENSRNOG00000008015
Prkcg GeneProduct ensembl:ENSRNOG00000054371
Myc GeneProduct ensembl:ENSRNOG00000004500
Sos2 GeneProduct ensembl:ENSRNOG00000004826
Tgfb2 GeneProduct ensembl:ENSRNOG00000002418
Elk1 GeneProduct ensembl:ENSRNOG00000010171
LOC100912585 GeneProduct ensembl:ENSRNOG00000002412
Dusp4 GeneProduct ensembl:ENSRNOG00000011921
Cacng3 GeneProduct ensembl:ENSRNOG00000012362
Apoptosis Pathway wikipathways:WP254
Hspa8 GeneProduct ensembl:ENSRNOG00000032585
Mapk12 GeneProduct ensembl:ENSRNOG00000031233
Mapk8ip1 GeneProduct ensembl:ENSRNOG00000058478
IP3 Metabolite chebi:16595
Ppm1a GeneProduct ensembl:ENSRNOG00000005916
Ca2+ Metabolite hmdb:HMDB0000464
Il1b GeneProduct ensembl:ENSRNOG00000004649
Elk4 GeneProduct ensembl:ENSRNOG00000007887
Traf2 GeneProduct ensembl:ENSRNOG00000006238
Mapk13 GeneProduct ensembl:ENSRNOG00000000515
Taok1 GeneProduct ensembl:ENSRNOG00000015692
Map2k6 GeneProduct ensembl:ENSRNOG00000004437
Dusp8 GeneProduct ensembl:ENSRNOG00000029394
Akt2 GeneProduct ensembl:ENSRNOG00000018677
Mapkapk5 GeneProduct ensembl:ENSRNOG00000001345
Rasa2 GeneProduct ensembl:ENSRNOG00000011909
Dusp7 GeneProduct ensembl:ENSRNOG00000010789
Ppp3r2 GeneProduct ensembl:ENSRNOG00000005368
Fgfr1 GeneProduct ensembl:ENSRNOG00000016050
Tgfb3 GeneProduct ensembl:ENSRNOG00000009867
Ppp3ca GeneProduct ensembl:ENSRNOG00000009882
Egf GeneProduct ensembl:ENSRNOG00000053979
Ddit3 GeneProduct ensembl:ENSRNOG00000006789
Map3k6 GeneProduct ensembl:ENSRNOG00000008936
Map3k8 GeneProduct ensembl:ENSRNOG00000016378
Ngf GeneProduct ensembl:ENSRNOG00000016571
LOC100911248 GeneProduct ensembl:ENSRNOG00000001868
Taok2 GeneProduct ensembl:ENSRNOG00000019964
cAMP Metabolite hmdb:HMDB0000058
Mapk3 GeneProduct ensembl:ENSRNOG00000053583
Mapk8 GeneProduct ensembl:ENSRNOG00000020155
Nr4a1 GeneProduct ensembl:ENSRNOG00000007607
Cell cycle Pathway wikipathways:WP179
Prkca GeneProduct ensembl:ENSRNOG00000003491
Atf4 GeneProduct ensembl:ENSRNOG00000017801
Ntf4 GeneProduct ensembl:ENSRNOG00000020783
Pdgfa GeneProduct ensembl:ENSRNOG00000001312
Atf4 GeneProduct ensembl:ENSRNOG00000017801
Ntrk2 GeneProduct ensembl:ENSRNOG00000018839
Faslg GeneProduct ensembl:ENSRNOG00000002978
Pdgfrb GeneProduct ensembl:ENSRNOG00000018461
Ppm1b GeneProduct ensembl:ENSRNOG00000030667
Fgfr2 GeneProduct ensembl:ENSRNOG00000016374
Cdc42 GeneProduct ensembl:ENSRNOG00000013536
Fgfr3 GeneProduct ensembl:ENSRNOG00000016818
Lamtor3 GeneProduct ensembl:ENSRNOG00000010552
Fgfr4 GeneProduct ensembl:ENSRNOG00000016763
Jun GeneProduct ensembl:ENSRNOG00000026293
Sos1 GeneProduct ensembl:ENSRNOG00000007106
Jund GeneProduct ensembl:ENSRNOG00000019568
Rras GeneProduct ensembl:ENSRNOG00000037247
Hras GeneProduct ensembl:ENSRNOG00000016611
Rps6ka5 GeneProduct ensembl:ENSRNOG00000004362
Map3k12 GeneProduct ensembl:ENSRNOG00000015134
Tp53 GeneProduct ensembl:ENSRNOG00000010756
Rras2 GeneProduct ensembl:ENSRNOG00000012258
Nfkb1 GeneProduct ensembl:ENSRNOG00000023258
Gng12 GeneProduct ensembl:ENSRNOG00000050231
Pla2g4c GeneProduct ensembl:ENSRNOG00000026764
Nf1 GeneProduct ensembl:ENSRNOG00000013780
Rasgrp2 GeneProduct ensembl:ENSRNOG00000021098
Akt1 GeneProduct ensembl:ENSRNOG00000028629
p53 signaling pathway Pathway None
Rasgrp3 GeneProduct ensembl:ENSRNOG00000032703
Rasgrp4 GeneProduct ensembl:ENSRNOG00000033744
Rasa1 GeneProduct ensembl:ENSRNOG00000029185
Rasgrf1 GeneProduct ensembl:ENSRNOG00000014025
HSPA6 GeneProduct None
Ca2+ Metabolite hmdb:HMDB0000464
Ntf3 GeneProduct ensembl:ENSRNOG00000019716
Rapgef2 GeneProduct ensembl:ENSRNOG00000021581
Phosphatidylinositolsignaling system Pathway None
Prkacb GeneProduct ensembl:ENSRNOG00000004978
Hspa1a GeneProduct ensembl:ENSRNOG00000045654
Prkaca GeneProduct ensembl:ENSRNOG00000005257
Stk3 GeneProduct ensembl:ENSRNOG00000011278
Dusp3 GeneProduct ensembl:ENSRNOG00000036798
Map4k3 GeneProduct ensembl:ENSRNOG00000007172
Chuk GeneProduct ensembl:ENSRNOG00000022485
Tgfbr2 GeneProduct ensembl:ENSRNOG00000013265
Nfkb2 GeneProduct ensembl:ENSRNOG00000019311
Map4k2 GeneProduct ensembl:ENSRNOG00000021061
Rela GeneProduct ensembl:ENSRNOG00000030888
Map2k7 GeneProduct ensembl:ENSRNOG00000001047
Relb GeneProduct ensembl:ENSRNOG00000033235
PPP3R1 GeneProduct None
Dusp9 GeneProduct ensembl:ENSRNOG00000055185
Nlk GeneProduct ensembl:ENSRNOG00000008704
Dusp2 GeneProduct ensembl:ENSRNOG00000013862
DAG Metabolite chebi:18035
Dusp16 GeneProduct ensembl:ENSRNOG00000006628
Fas GeneProduct ensembl:ENSRNOG00000019142
Mknk2 GeneProduct ensembl:ENSRNOG00000029028
Pla2g4a GeneProduct ensembl:ENSRNOG00000002657
Nfatc3 GeneProduct ensembl:ENSRNOG00000054264
Map3k5 GeneProduct ensembl:ENSRNOG00000031700
Map3k11 GeneProduct ensembl:ENSRNOG00000020773
Taok3 GeneProduct ensembl:ENSRNOG00000001138
Dusp6 GeneProduct ensembl:ENSRNOG00000023896
Map2k2 GeneProduct ensembl:ENSRNOG00000020005
PPP5D1 GeneProduct None
Mapk11 GeneProduct ensembl:ENSRNOG00000006984
Rps6ka4 GeneProduct ensembl:ENSRNOG00000021117
Mapkapk3 GeneProduct ensembl:ENSRNOG00000014832
Rac3 GeneProduct ensembl:ENSRNOG00000048172
Mapk8ip2 GeneProduct ensembl:ENSRNOG00000032828
Mapk8ip3 GeneProduct ensembl:ENSRNOG00000033568
Flnb GeneProduct ensembl:ENSRNOG00000009470
Flnc GeneProduct ensembl:ENSRNOG00000007281
Hspa1a GeneProduct ensembl:ENSRNOG00000045654
Hspa1l GeneProduct ensembl:ENSRNOG00000047966
Hspa2 GeneProduct ensembl:ENSRNOG00000006472
Mras GeneProduct ensembl:ENSRNOG00000014060
Nras GeneProduct ensembl:ENSRNOG00000023079
Kras GeneProduct ensembl:ENSRNOG00000009338
Raf1 GeneProduct ensembl:ENSRNOG00000010153
Pla2g4f GeneProduct ensembl:ENSRNOG00000008135
Pla2g4b GeneProduct ensembl:ENSRNOG00000007447
Pla2g4e GeneProduct ensembl:ENSRNOG00000024904
Cacng2 GeneProduct ensembl:ENSRNOG00000006226
Cacng5 GeneProduct ensembl:ENSRNOG00000003288
Cacng4 GeneProduct ensembl:ENSRNOG00000003262
Cacna2d3 GeneProduct ensembl:ENSRNOG00000031287
Cacng8 GeneProduct ensembl:ENSRNOG00000057848
Cacng7 GeneProduct ensembl:ENSRNOG00000056257
Cacng6 GeneProduct ensembl:ENSRNOG00000057852
Cacna1a GeneProduct ensembl:ENSRNOG00000052707
Cacna1b GeneProduct ensembl:ENSRNOG00000004560
Cacna1c GeneProduct ensembl:ENSRNOG00000007090
Cacna1d GeneProduct ensembl:ENSRNOG00000013147
Cacna1e GeneProduct ensembl:ENSRNOG00000002863
Cacna1f GeneProduct ensembl:ENSRNOG00000010348
Cacna1s GeneProduct ensembl:ENSRNOG00000046231
Cacna2d1 GeneProduct ensembl:ENSRNOG00000033531
Cacnb1 GeneProduct ensembl:ENSRNOG00000004518
Cacnb2 GeneProduct ensembl:ENSRNOG00000018378
Cacnb3 GeneProduct ensembl:ENSRNOG00000054274
Cacnb4 GeneProduct ensembl:ENSRNOG00000007666
Cacng1 GeneProduct ensembl:ENSRNOG00000003245
CACNA1I GeneProduct None
Cacna1h GeneProduct ensembl:ENSRNOG00000033893
Cacna1g GeneProduct ensembl:ENSRNOG00000060528
Cacna2d2 GeneProduct ensembl:ENSRNOG00000015835
Cacna2d4 GeneProduct ensembl:ENSRNOG00000008031
Fgf4 GeneProduct ensembl:ENSRNOG00000020890
Fgf1 GeneProduct ensembl:ENSRNOG00000013867
Fgf2 GeneProduct ensembl:ENSRNOG00000017392
Fgf3 GeneProduct ensembl:ENSRNOG00000020888
Fgf4 GeneProduct ensembl:ENSRNOG00000020890
Fgf5 GeneProduct ensembl:ENSRNOG00000022631
Fgf6 GeneProduct ensembl:ENSRNOG00000053662
Fgf7 GeneProduct ensembl:ENSRNOG00000009425
Fgf8 GeneProduct ensembl:ENSRNOG00000017524
Fgf9 GeneProduct ensembl:ENSRNOG00000011471
Fgf10 GeneProduct ensembl:ENSRNOG00000012278
Fgf11 GeneProduct ensembl:ENSRNOG00000014882
Fgf12 GeneProduct ensembl:ENSRNOG00000001931
Fgf13 GeneProduct ensembl:ENSRNOG00000042753
Fgf14 GeneProduct ensembl:ENSRNOG00000009288
Fgf20 GeneProduct ensembl:ENSRNOG00000000109
Fgf21 GeneProduct ensembl:ENSRNOG00000020990
Fgf22 GeneProduct ensembl:ENSRNOG00000008960
Fgf23 GeneProduct ensembl:ENSRNOG00000052205
Fgf18 GeneProduct ensembl:ENSRNOG00000048389
Fgf17 GeneProduct ensembl:ENSRNOG00000012912
Fgf16 GeneProduct ensembl:ENSRNOG00000061530
Fgf19 GeneProduct ensembl:ENSRNOG00000020899
Pak2 GeneProduct ensembl:ENSRNOG00000001747
Pak1 GeneProduct ensembl:ENSRNOG00000029784

References

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