Methionine de novo and salvage pathway (WP3580)

Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway Pathway adapted from [http://www.kegg.jp/kegg-bin/show_pathway?map00270 KEGG]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3580 CPTAC Assay Portal]
last edited

Authors

Paul Cavuoto, Mkutmon, DeSl, Marvin M2, AlexanderPico, Egonw, Khanspers, MaintBot, Eweitz, and Finterly

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: classic metabolic pathway methionine biosynthetic pathway

Participants

Label Type Compact Identifier
FAD Metabolite hmdb:HMDB0001248
magnesium Metabolite chebi:25107
MethylatedMetabolite Metabolite None
MTRR GeneProduct None
Dimethylglycine Metabolite hmdb:HMDB0000092
potassium Metabolite chebi:26216
Methyltranferases GeneProduct None
Metabolite Metabolite None
S-Adenosylmethionine Metabolite hmdb:HMDB0001185
L-Methionine Metabolite hmdb:HMDB0000696
MAT2A GeneProduct ensembl:ENSG00000168906
MAT2B GeneProduct ensembl:ENSG00000038274
S-Adenosylhomocysteine Metabolite hmdb:HMDB0000939
Homocysteine Metabolite hmdb:HMDB0000742
AHCY GeneProduct ensembl:ENSG00000101444
NAD Metabolite hmdb:HMDB0000902
Cobalamin Metabolite hmdb:HMDB0002174
MTR GeneProduct ensembl:ENSG00000116984
Zinc Metabolite hmdb:HMDB0015532
Zinc Metabolite hmdb:HMDB0015532
BHMT GeneProduct ensembl:ENSG00000145692
Choline Metabolite hmdb:HMDB0000097
Betaine Metabolite hmdb:HMDB0000043
CHDH GeneProduct ensembl:ENSG00000016391
Adenosine Metabolite hmdb:HMDB0000050
Water Metabolite hmdb:HMDB0002111
Water Metabolite hmdb:HMDB0002111
ATP Metabolite hmdb:HMDB0000538
Diphosphate Metabolite chebi:18361
Phosphate Metabolite hmdb:HMDB0001429
5-Methyltetrahydrofolic acid Metabolite hmdb:HMDB0001396
Tetrahydrofolic acid Metabolite hmdb:HMDB0001846
Methionine sulfoxide Metabolite hmdb:HMDB0002005
L-Methionine Metabolite hmdb:HMDB0000696
Protein-bound Methionine sulfoxide Metabolite None
Protein-bound Methionine Metabolite None
MSRA GeneProduct ensembl:ENSG00000175806
MSRB2 GeneProduct ensembl:ENSG00000148450
MSRB3 GeneProduct ensembl:ENSG00000174099
Thioredoxin Protein uniprot:H9ZYJ2
Water Metabolite hmdb:HMDB0002111
Thioredoxin disulfide Metabolite chebi:18191
Thioredoxin disulfide Metabolite chebi:18191
Water Metabolite hmdb:HMDB0002111
Thioredoxin Protein uniprot:H9ZYJ2
Thioredoxin disulfide Metabolite chebi:18191
Water Metabolite hmdb:HMDB0002111
Thioredoxin Protein uniprot:H9ZYJ2
S-Adenosylmethioninamine Metabolite hmdb:HMDB0000988
2-Oxo-4-methylthiobutanoic acid Metabolite hmdb:HMDB0001553
pyruvate Metabolite chebi:15361
AMD1 GeneProduct ensembl:ENSG00000123505
Carbon dioxide Metabolite hmdb:HMDB0001967
TAT GeneProduct ensembl:ENSG00000198650
Pyridoxal 5-phosphate Metabolite HMDB
Oxoglutaric acid Metabolite HMDB
L-Glutamic acid Metabolite HMDB
FAD Metabolite HMDB
Ammonia Metabolite HMDB
IL4I1 GeneProduct Ensembl
Hydrogen peroxide Metabolite HMDB
Oxygen Metabolite HMDB
Water Metabolite HMDB
1,2-Dihydroxy-3-keto-5-methylthiopentene Metabolite HMDB
5-(methylthio)-2,3-Dioxopentyl phosphate Metabolite HMDB
5-Methylthioribulose 1-phosphate Metabolite HMDB
5-Methylthioadenosine Metabolite hmdb:HMDB0001173
5-Methylthioribose 1-phosphate Metabolite hmdb:HMDB0000963
ODC1 GeneProduct ensembl:ENSG00000115758
Ornithine Metabolite hmdb:HMDB0000214
Carbon dioxide Metabolite hmdb:HMDB0001967
Putrescine Metabolite hmdb:HMDB0001414
SRM GeneProduct ensembl:ENSG00000116649
Spermidine Metabolite hmdb:HMDB0001257
Spermidine Metabolite hmdb:HMDB0001257
Spermine Metabolite hmdb:HMDB0001256
SMS GeneProduct ensembl:ENSG00000102172
Cellular Proliferation Pathway None
MTAP GeneProduct ensembl:ENSG00000099810
Adenine Metabolite hmdb:HMDB0000034
Phosphate Metabolite hmdb:HMDB0001429
MRI1 GeneProduct ensembl:ENSG00000037757
Zinc Metabolite hmdb:HMDB0015532
APIP GeneProduct ensembl:ENSG00000149089
Water Metabolite hmdb:HMDB0002111
Iron Metabolite hmdb:HMDB0000692
ADI1 GeneProduct ensembl:ENSG00000182551
Formic acid Metabolite hmdb:HMDB0000142
Oxygen Metabolite hmdb:HMDB0001377
ENOPH1 GeneProduct ensembl:ENSG00000145293
Magnesium Metabolite hmdb:HMDB0000547
Phosphoric acid Metabolite hmdb:HMDB0002142
Water Metabolite hmdb:HMDB0002111
Oxygen Metabolite hmdb:HMDB0001377
Formic acid Metabolite hmdb:HMDB0000142
3-Methylthiopropionic acid Metabolite hmdb:HMDB0001527
Carbon monoxide Metabolite hmdb:HMDB0001361
Nickel Metabolite hmdb:HMDB0002457
ADI1 GeneProduct ensembl:ENSG00000182551
MAT1A GeneProduct ensembl:ENSG00000151224
Potassium Metabolite chebi:26216
Water Metabolite hmdb:HMDB0002111
ATP Metabolite hmdb:HMDB0000538
Diphosphate Metabolite chebi:18361
Phosphate Metabolite hmdb:HMDB0001429
cobalt(2+) ion Metabolite chebi:48828
magnesium Metabolite chebi:25107
cobalt(2+) ion Metabolite chebi:48828

References

  1. Alvarez L, Corrales F, Martín-Duce A, Mato JM. Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies. Biochem J. 1993 Jul 15;293 ( Pt 2)(Pt 2):481–6. PubMed Europe PMC Scholia