Circadian rhythm genes (WP3594)

This is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rhythm" annotation (taxon = homo sapiens). According to supplementary information they were clustered in major (neurotransmitters, hormons, appetite regulation and immune system) and minor groups. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


Fehrhart, Mkutmon, Ddigles, Khanspers, DeSl, and Eweitz

Cited In


Homo sapiens



Pathway Ontology: regulatory pathway


Label Type Compact Identifier
CDK4 GeneProduct uniprot:P11802
LGR4 GeneProduct uniprot:Q9BXB1
HEBP1 GeneProduct uniprot:Q9NRV9
ROCK2 GeneProduct uniprot:O75116
TOP1 GeneProduct uniprot:P11387
ATF5 GeneProduct uniprot:Q9Y2D1
DYRK1A GeneProduct uniprot:Q13627
BTBD9 GeneProduct uniprot:Q96Q07
MAPK8 GeneProduct uniprot:P45983
PHLPP1 GeneProduct uniprot:O60346
CUL1 GeneProduct uniprot:Q13616
NR2F6 GeneProduct uniprot:P10588
NAMPT GeneProduct uniprot:P43490
ID3 GeneProduct uniprot:Q02535
FAS GeneProduct uniprot:P25445
PER3 GeneProduct uniprot:Q8TAR6
PRF1 GeneProduct uniprot:P14222
CIPC GeneProduct uniprot:G3V3Y7
SERPINE1 GeneProduct uniprot:P05121
MC3R GeneProduct uniprot:P41968
AGRP GeneProduct uniprot:O00253
HTR7 GeneProduct uniprot:P34969
PPP1CC GeneProduct uniprot:P36873
PROX1 GeneProduct uniprot:Q92786
CIART GeneProduct uniprot:Q8N365
SREBF1 GeneProduct uniprot:P36956
CLDN4 GeneProduct uniprot:O14493
PRKCG GeneProduct uniprot:P05129
HDAC1 GeneProduct uniprot:Q13547
Q59FM5 GeneProduct uniprot:Q59FM5
DRD2 GeneProduct uniprot:P14416
NR1H3 GeneProduct uniprot:Q13133
NONO GeneProduct uniprot:Q15233
SLC6A4 GeneProduct uniprot:P31645
STAR GeneProduct uniprot:P49675
MAGEL2 GeneProduct ensembl:ENSG00000254585
CRX GeneProduct uniprot:O43186
CIPC GeneProduct uniprot:G3V5Y7
NTRK1 GeneProduct uniprot:P04629
DRD1 GeneProduct uniprot:P21728
PRKDC GeneProduct uniprot:P78527
KLF9 GeneProduct uniprot:Q13886
TYMS GeneProduct uniprot:P04818
AANAT GeneProduct uniprot:Q16613
MTNR1B GeneProduct uniprot:P49286
PROK1 GeneProduct uniprot:P58294
PPARG GeneProduct uniprot:P37231
NR1D2 GeneProduct uniprot:Q14995
NKX2-1 GeneProduct uniprot:P43699
SLC9A3 GeneProduct uniprot:P48764
PAX4 GeneProduct uniprot:O43316
EZH2 GeneProduct uniprot:Q15910
KDM5A GeneProduct uniprot:P29375
HCRTR2 GeneProduct uniprot:O43614
MYBBP1A GeneProduct uniprot:Q9BQG0
PSPC1 GeneProduct uniprot:Q8WXF1
SIX3 GeneProduct uniprot:O95343
FBXL3 GeneProduct uniprot:Q9UKT7
USP2 GeneProduct uniprot:O75604
ZFHX3 GeneProduct uniprot:Q15911
CIPC GeneProduct uniprot:Q9C0C6
NPY2R GeneProduct uniprot:P49146
NPAS2 GeneProduct uniprot:Q99743
NCOR1 GeneProduct uniprot:O75376
UTS2 GeneProduct uniprot:O95399
BHLHE40 GeneProduct uniprot:O14503
NAGLU GeneProduct uniprot:P54802
CIPC GeneProduct uniprot:G3V5J4
HCRTR1 GeneProduct uniprot:O43613
KMT2A GeneProduct uniprot:Q03164
CARTPT GeneProduct uniprot:Q16568
SOX14 GeneProduct uniprot:O95416
KCNH7 GeneProduct uniprot:Q9NS40
TPH1 GeneProduct uniprot:P17752
SKP1 GeneProduct uniprot:P63208
CCAR2 GeneProduct uniprot:Q8N163
SIN3A GeneProduct uniprot:Q96ST3
ADCY1 GeneProduct uniprot:Q08828
NGFR GeneProduct uniprot:P08138
PPP1CB GeneProduct uniprot:P62140
MTNR1A GeneProduct uniprot:P48039
GHRH GeneProduct uniprot:P01286
TIMELESS GeneProduct uniprot:Q9UNS1
CSNK1D GeneProduct uniprot:P48730
OPN4 GeneProduct uniprot:Q9UHM6
DBP GeneProduct uniprot:Q10586
ID2 GeneProduct uniprot:Q02363
CSNK1E GeneProduct uniprot:P49674
SUV39H1 GeneProduct uniprot:O43463
PTEN GeneProduct uniprot:P60484
NPS GeneProduct uniprot:P0C0P6
SIRT1 GeneProduct uniprot:Q96EB6
PRKAA2 GeneProduct uniprot:P54646
NFIL3 GeneProduct uniprot:Q16649
GNA11 GeneProduct uniprot:P29992
HDAC3 GeneProduct uniprot:O15379
UBA52 GeneProduct uniprot:P62987
PRKG2 GeneProduct uniprot:Q13237
ATOH7 GeneProduct uniprot:Q8N100
GFPT1 GeneProduct uniprot:Q06210
DRD4 GeneProduct uniprot:P21917
ID4 GeneProduct uniprot:P47928
CREB1 GeneProduct uniprot:P16220
TP53 GeneProduct uniprot:P04637
HNF1B GeneProduct uniprot:P35680
PASD1 GeneProduct uniprot:Q8IV76
HS3ST2 GeneProduct uniprot:Q9Y278
CPT1A GeneProduct uniprot:P50416
CRH GeneProduct uniprot:P06850
DRD3 GeneProduct uniprot:P35462
NMS GeneProduct uniprot:Q5H8A3
PML GeneProduct uniprot:P29590
UBC GeneProduct uniprot:P0CG48
MAGED1 GeneProduct uniprot:Q9Y5V3
NTRK3 GeneProduct uniprot:Q16288
FBXL21 GeneProduct ensembl:ENSG00000164616
TNFRSF11A GeneProduct uniprot:Q9Y6Q6
CREM GeneProduct uniprot:Q03060
CRY1 GeneProduct uniprot:Q16526
ARNT2 GeneProduct uniprot:Q9HBZ2
IL6 GeneProduct uniprot:P05231
PROK2 GeneProduct uniprot:Q9HC23
RORA GeneProduct uniprot:P35398
RORC GeneProduct uniprot:P51449
CLOCK GeneProduct uniprot:O15516
GNAQ GeneProduct ensembl:ENSG00000156052
MTA1 GeneProduct uniprot:Q13330
PRKCDBP GeneProduct uniprot:Q969G5
HCRTR1 GeneProduct uniprot:O43613
THRAP3 GeneProduct uniprot:Q9Y2W1
SUV39H2 GeneProduct uniprot:Q9H5I1
PROKR1 GeneProduct uniprot:Q8TCW9
TH GeneProduct uniprot:P07101
AHCY GeneProduct uniprot:P23526
BHLHE41 GeneProduct uniprot:Q9C0J9
NR1D1 GeneProduct uniprot:P20393
NPAS2 GeneProduct uniprot:Q99743
PRKAA1 GeneProduct uniprot:Q13131
JUN GeneProduct uniprot:P05412
ADORA2A GeneProduct uniprot:P29274
OPN3 GeneProduct uniprot:Q9H1Y3
KCNMA1 GeneProduct uniprot:Q12791
PPARA GeneProduct uniprot:Q07869
CRY2 GeneProduct uniprot:Q49AN0
DDC GeneProduct uniprot:P20711
F7 GeneProduct uniprot:P08709
METTL3 GeneProduct uniprot:Q86U44
ADORA1 GeneProduct uniprot:P30542
CRTC1 GeneProduct uniprot:Q6UUV9
HNRNPD GeneProduct uniprot:Q14103
PER2 GeneProduct uniprot:O15055
NCOA2 GeneProduct uniprot:Q15596
RAI1 GeneProduct uniprot:Q7Z5J4
TOP2A GeneProduct uniprot:P11388
NOCT GeneProduct uniprot:Q9UK39
KLF10 GeneProduct uniprot:Q13118
NRIP1 GeneProduct uniprot:P48552
SETX GeneProduct uniprot:Q7Z333
HOMER1 GeneProduct uniprot:Q86YM7
DBP GeneProduct uniprot:M0QXP1
PER1 GeneProduct uniprot:O15534
ATF4 GeneProduct uniprot:P18848
DHX9 GeneProduct uniprot:Q08211
NCOA2 GeneProduct uniprot:Q15596
CST3 GeneProduct uniprot:P01034
MTTP GeneProduct uniprot:E9PBP6
SIK1 GeneProduct uniprot:P57059
RBM4 GeneProduct uniprot:Q9BWF3
CHRNB2 GeneProduct uniprot:P17787
CIPC GeneProduct uniprot:G3V405
SFPQ GeneProduct uniprot:P23246
UBE3A GeneProduct uniprot:Q05086
OPRL1 GeneProduct uniprot:P41146
ADCY1 GeneProduct uniprot:Q08828
EGR1 GeneProduct uniprot:P18146
MAPK10 GeneProduct uniprot:P53779
OGT GeneProduct uniprot:O15294
ARNTL2 GeneProduct uniprot:Q8WYA1
C1orf51 GeneProduct uniprot:Q5TB13
DDX5 GeneProduct uniprot:P17844
ARNT GeneProduct uniprot:P27540
JUND GeneProduct uniprot:P17535
MAPK9 GeneProduct uniprot:P45984
PPP1CA GeneProduct uniprot:P62136
RBM4B GeneProduct uniprot:Q9BQ04
PPP1CB GeneProduct uniprot:P62140
UTS2R GeneProduct uniprot:Q9UKP6
EGR3 GeneProduct uniprot:Q06889
GSK3B GeneProduct uniprot:P49841
KCND2 GeneProduct uniprot:Q9NZV8
HCRTR2 GeneProduct uniprot:O43614
AVP GeneProduct uniprot:P01185
AHR GeneProduct uniprot:P35869
CHRM1 GeneProduct uniprot:P11229
HNRNPU GeneProduct uniprot:Q00839
SFTPC GeneProduct uniprot:P11686
PRMT5 GeneProduct uniprot:O14744
HDAC2 GeneProduct uniprot:Q92769
ADA GeneProduct uniprot:P00813
PTGDS GeneProduct uniprot:P41222
EP300 GeneProduct uniprot:Q09472
RORB GeneProduct uniprot:Q92753
BTRC GeneProduct uniprot:Q9Y297
PROKR2 GeneProduct uniprot:Q8NFJ6
LEP GeneProduct uniprot:P41159
ADIPOQ GeneProduct uniprot:Q15848
RELB GeneProduct uniprot:Q01201
GHRL GeneProduct uniprot:Q9UBU3
NLGN1 GeneProduct uniprot:Q8N2Q7
NOS2 GeneProduct uniprot:P35228
TPH2 GeneProduct uniprot:Q8IWU9
RPS27A GeneProduct uniprot:P62979
PPARGC1A GeneProduct uniprot:Q9UBK2
ARNTL GeneProduct uniprot:O00327
FBXW11 GeneProduct uniprot:Q9UKB1
HOMER1 GeneProduct uniprot:Q86YM7
NRIP1 GeneProduct uniprot:P48552
PROKR2 GeneProduct uniprot:Q8NFJ6
C1orf51 GeneProduct uniprot:Q5TB13
AGRP GeneProduct uniprot:O00253
PROKR1 GeneProduct uniprot:Q8TCW9
SIRT1 GeneProduct uniprot:Q96EB6
PROK2 GeneProduct uniprot:Q9HC23
BHLHE41 GeneProduct uniprot:Q9C0J9
PRKAA1 GeneProduct uniprot:Q13131