mir-124 predicted interactions with cell cycle and differentiation (WP3595)

Schematic of predicted interactions of miR-124 with cell cycle and cell differentiation machinery. A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-124 is selectively toxic, mainly by inducing terminal cell differentiation via its target SIX4.
last edited

Authors

Khanspers, Ryanmiller, and Mkutmon

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: regulatory pathway

Participants

Label Type Compact Identifier
KLB1 GeneProduct ensembl:ENSG00000118046
hsa-miR-124a Rna mirbase.mature:MIMAT0000422
PTBP GeneProduct ensembl:ENSG00000011304
SIX4 GeneProduct ensembl:ENSG00000100625
STRADB GeneProduct ensembl:ENSG00000082146
SCP1 GeneProduct ensembl:ENSG00000144579
AMPK GeneProduct ensembl:ENSG00000132356

References

  1. Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Mol Syst Biol. 2015 Dec 11;11(12):842. PubMed Europe PMC Scholia