miR-517 relationship with ARCN1 and USP1 (WP3596)

Schematic summarizing predicted miR-517a relationships with ARCN1 and USP1. A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-517a targets a common vulnerability, primarily via its target ARCN1. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3596 CPTAC Assay Portal].
last edited

Authors

Khanspers, Ryanmiller, and Mkutmon

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: regulatory pathway

Participants

Label Type Compact Identifier
hsa-miR-517a-3p Rna mirbase.mature:MIMAT0002852
p21 GeneProduct ensembl:ENSG00000124762
ID1 GeneProduct ensembl:ENSG00000125968
USP1 GeneProduct ensembl:ENSG00000162607
ARCN1 GeneProduct ensembl:ENSG00000095139
ID2 GeneProduct ensembl:ENSG00000115738

References

  1. Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Mol Syst Biol. 2015 Dec 11;11(12):842. PubMed Europe PMC Scholia