Lipid particles composition (WP3601)

This particle describes the chemical composition of various lipid particles. See also [https://www.wikipathways.org/index.php/Pathway:WP430] for a basic overview of cholesterol synthesis, and for the disease related to the lipoproteins in this pathway see [https://www.wikipathways.org/index.php/Pathway:WP4522]. Additional sources - A. Goldberg, Overview of Lipid Metabolism, 2015. http://www.msdmanuals.com/professional/endocrine-and-metabolic-disorders/lipid-disorders/overview-of-lipid-metabolism
last edited

Authors

Egonw, MaintBot, Ariutta, DeSl, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: lipid metabolic pathway

Participants

Label Type Compact Identifier
ROS Metabolite chebi:26523
cholesterylester Metabolite chebi:17002
Apo C-III Protein uniprot:P02656
Apo C-II Protein uniprot:P02655
HDL Metabolite chebi:39025
cholesterol Metabolite hmdb:HMDB0000067
TG Metabolite chebi:17855
CETP GeneProduct ensembl:ENSG00000087237
LDLR GeneProduct ensembl:ENSG00000130164
Apo A-II Protein uniprot:P02652
Apo E Protein uniprot:P02649
FA Metabolite chebi:35366
IDL Complex None
LCAT GeneProduct ensembl:ENSG00000213398
LDL Metabolite chebi:39026
Apo A-I Protein uniprot:P02647
LPL GeneProduct ensembl:ENSG00000175445
Apo B-100 Protein uniprot:P04114
VLDL Metabolite chebi:39027
cholesterylester Metabolite chebi:17002
Apo E Protein uniprot:P02649
Apo C-II Protein uniprot:P02655
Apo C-III Protein uniprot:P02656
Apo B-48 Protein None
Apo E Protein uniprot:P02649
Apo C-II Protein uniprot:P02655
Apo C-III Protein uniprot:P02656
Chylomicron Complex None
TG Metabolite chebi:17855
glycerol Metabolite hmdb:HMDB0000131
cholesterol Metabolite hmdb:HMDB0000067
cholesterol Metabolite hmdb:HMDB0000067
cholesterol Metabolite hmdb:HMDB0000067
oxLDL Metabolite chebi:60151
cholesterol Metabolite hmdb:HMDB0000067
Apo E Protein uniprot:P02649

References

  1. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988 Apr 29;240(4852):622–30. PubMed Europe PMC Scholia
  2. Steinberg D. Lewis A. Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis. Circulation. 1997 Feb 18;95(4):1062–71. PubMed Europe PMC Scholia