Photodynamic therapy-induced NF-kB survival signaling (WP3617)

Photodynamic therapy may induce a pro-inflammatory and angiogenic response mediated by NF-κB. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3617 CPTAC Assay Portal]
last edited

Authors

Ruudweijer, MaintBot, Khanspers, AlexanderPico, and Fehrhart

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Disease Ontology: cancer

Pathway Ontology: altered regulatory pathway

Participants

Label Type Compact Identifier
CSF2 GeneProduct ncbigene:1437
IL8 GeneProduct ncbigene:3576
IL6 GeneProduct ncbigene:3569
IL1B GeneProduct ncbigene:3553
IL1A GeneProduct ncbigene:3552
IL2 GeneProduct ncbigene:3558
VEGFA GeneProduct ncbigene:7422
CCND1 GeneProduct ncbigene:595
TNF GeneProduct ncbigene:7124
EGLN2 GeneProduct ncbigene:112398
IKBKB GeneProduct ncbigene:3551
CHUK GeneProduct ncbigene:1147
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ncbigene:5970
REL GeneProduct ncbigene:5966
NFKB2 GeneProduct ncbigene:4791
TRAF6 GeneProduct ncbigene:7189
TNF GeneProduct ncbigene:7124
PTGS2 GeneProduct ncbigene:5743
ICAM1 GeneProduct ncbigene:3383
VCAM1 GeneProduct ncbigene:7412
CXCL2 GeneProduct ncbigene:2920
CD40LG GeneProduct ncbigene:959
SELE GeneProduct ncbigene:6401
TNFRSF1A GeneProduct ncbigene:7132
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ncbigene:5970
REL GeneProduct ncbigene:5966
NFKB2 GeneProduct ncbigene:4791
RELB GeneProduct ncbigene:5971
RELB GeneProduct ncbigene:5971
PTGS2 GeneProduct ncbigene:5743
CFLAR GeneProduct ncbigene:8837
BIRC2 GeneProduct ncbigene:329
BIRC5 GeneProduct ncbigene:332
BIRC3 GeneProduct ncbigene:330
BCL2A1 GeneProduct ncbigene:597
BCL2L2 GeneProduct ncbigene:599
MMP3 GeneProduct ncbigene:4314
MMP9 GeneProduct ncbigene:4318
VEGFA GeneProduct ncbigene:7422
MMP2 GeneProduct ncbigene:4313
MMP1 GeneProduct ncbigene:4312
PTGS2 GeneProduct ncbigene:5743

References

  1. Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M. Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies. Cancer Metastasis Rev. 2015 Dec;34(4):643–90. PubMed Europe PMC Scholia
  2. Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, et al. Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells. BMC Cancer. 2015 Dec 26;15:1014. PubMed Europe PMC Scholia