Lung fibrosis (WP3624)

Lung fibrosis pathway linked to events (molecular initiating event, key events and associative events) in a putative Adverse Outcome Pathway for lung fibrosis. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3624 CPTAC Assay Portal]
last edited

Authors

Fehrhart, Penny, Lindarieswijk, Khanspers, MaintBot, Jmelius, Egonw, and Mkutmon

Cited In

Organism

Homo sapiens

Communities

Adverse Outcome Pathways Diseases Nanomaterials Pathways

Annotations

Disease Ontology: pulmonary fibrosis

Pathway Ontology: respiratory system disease pathway carbon nanotube response pathway

Participants

Label Type Compact Identifier
ELMOD2 GeneProduct ensembl:ENSG00000179387
Chemokine signaling Pathway wikipathways:WP3929
Matrixmetalloproteinases Pathway wikipathways:WP129
Collagen producton Pathway wikipathways:WP2798
Chondrocytedifferentiation Pathway wikipathways:WP474
Stressfibre assembly Pathway wikipathways:WP2666
DifferentiationPathway Pathway wikipathways:WP2848
NRF2signaling Pathway wikipathways:WP2884
TGF betasignaling Pathway wikipathways:WP560
Cytokinesand inflammatoryresponse Pathway wikipathways:WP530
Apoptosis Pathway wikipathways:WP254
RTEL1 GeneProduct ensembl:ENSG00000258366
CXCL2 GeneProduct ensembl:ENSG00000081041
SPP1 GeneProduct ensembl:ENSG00000118785
DPP9 GeneProduct ensembl:ENSG00000142002
FGF1 GeneProduct ensembl:ENSG00000113578
CCL4 GeneProduct ensembl:ENSG00000275302
SMAD7 GeneProduct ensembl:ENSG00000101665
TERC GeneProduct ensembl:ENSG00000270141
CTGF GeneProduct ensembl:ENSG00000118523
SFTPA2 GeneProduct ensembl:ENSG00000185303
PARN GeneProduct ensembl:ENSG00000140694
MAPKsignaling Pathway wikipathways:WP382
CCL2 GeneProduct ensembl:ENSG00000108691
SERPINA1 GeneProduct ensembl:ENSG00000197249
SKIL GeneProduct ensembl:ENSG00000136603
TNF GeneProduct ensembl:ENSG00000232810
SFTPA1 GeneProduct ensembl:ENSG00000122852
IL6 GeneProduct ensembl:ENSG00000136244
Oxidative Stress Pathway wikipathways:WP408
EDN1 GeneProduct ensembl:ENSG00000078401
ELN GeneProduct ensembl:ENSG00000049540
CSF3 GeneProduct ensembl:ENSG00000108342
GREM1 GeneProduct ensembl:ENSG00000166923
Inflammasomeactivation Pathway wikipathways:WP288
DSP GeneProduct ensembl:ENSG00000096696
TERT GeneProduct ensembl:ENSG00000164362
MECP2 GeneProduct ensembl:ENSG00000169057
CXCL8 GeneProduct ensembl:ENSG00000169429
OBFC1 GeneProduct ensembl:ENSG00000107960
CALCA GeneProduct ensembl:ENSG00000110680
TGFA GeneProduct ensembl:ENSG00000163235
IL13 GeneProduct ensembl:ENSG00000169194
IL1B GeneProduct ensembl:ENSG00000125538
CCR3 GeneProduct ensembl:ENSG00000183625
CCL5 GeneProduct ensembl:ENSG00000271503
PDGFA GeneProduct ensembl:ENSG00000197461
NADPHoxidase Pathway wikipathways:WP3396
CCL11 GeneProduct ensembl:ENSG00000172156
ATP11A GeneProduct ensembl:ENSG00000068650
FGF2 GeneProduct ensembl:ENSG00000138685
Inflammation Pathway wikipathways:WP453
CMA1 GeneProduct ensembl:ENSG00000092009
IL5 GeneProduct ensembl:ENSG00000113525
Coagulation disturbances Pathway wikipathways:WP558
EGF GeneProduct ensembl:ENSG00000138798
TIMP1 GeneProduct ensembl:ENSG00000102265
NF-KB Pathway kegg.pathway:hsa04064
IL12B GeneProduct ensembl:ENSG00000113302
BMP7 GeneProduct ensembl:ENSG00000101144
PDGFB GeneProduct ensembl:ENSG00000100311
PTX3 GeneProduct ensembl:ENSG00000163661
NFE2L2 GeneProduct ensembl:ENSG00000116044
MMP9 GeneProduct ensembl:ENSG00000100985
FGF7 GeneProduct ensembl:ENSG00000140285
MUC5B GeneProduct ensembl:ENSG00000117983
CEBPB GeneProduct ensembl:ENSG00000172216
CYSLTR2 GeneProduct ensembl:ENSG00000152207
HMOX1 GeneProduct ensembl:ENSG00000100292
p38 MAPK Pathway wikipathways:WP400
MMP2 GeneProduct ensembl:ENSG00000087245
HGF GeneProduct ensembl:ENSG00000019991
SFTPC GeneProduct ensembl:ENSG00000168484
CCR2 GeneProduct ensembl:ENSG00000121807
IL4 GeneProduct ensembl:ENSG00000113520
CSF2 GeneProduct ensembl:ENSG00000164400
PLAU GeneProduct ensembl:ENSG00000122861
FAM13A GeneProduct ensembl:ENSG00000138640
CCL3 GeneProduct ensembl:ENSG00000277632
MT2A GeneProduct ensembl:ENSG00000125148
IGF1 GeneProduct ensembl:ENSG00000017427
TGFB1 GeneProduct ensembl:ENSG00000105329
ROSproduction Metabolite chebi:26523
ROSproduction Metabolite chebi:26523
NF-KB Pathway kegg.pathway:hsa04064
Inflammasomeactivation Pathway wikipathways:WP288
Toll-like receptorsignaling Pathway wikipathways:WP75

References

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  2. Naumanen P, Lappalainen P, Hotulainen P. Mechanisms of actin stress fibre assembly. J Microsc. 2008 Sep;231(3):446–54. PubMed Europe PMC Scholia
  3. Todd NW, Luzina IG, Atamas SP. Molecular and cellular mechanisms of pulmonary fibrosis. Fibrogenesis Tissue Repair. 2012 Jul 23;5(1):11. PubMed Europe PMC Scholia
  4. Montojo J, Zuberi K, Rodriguez H, Bader GD, Morris Q. GeneMANIA: Fast gene network construction and function prediction for Cytoscape. F1000Res. 2014 Jul 1;3:153. PubMed Europe PMC Scholia
  5. Davis AP, Grondin CJ, Lennon-Hopkins K, Saraceni-Richards C, Sciaky D, King BL, et al. The Comparative Toxicogenomics Database’s 10th year anniversary: update 2015. Nucleic Acids Res. 2015 Jan;43(Database issue):D914-20. PubMed Europe PMC Scholia
  6. Vietti G, Lison D, van den Brule S. Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP). Part Fibre Toxicol. 2016 Feb 29;13:11. PubMed Europe PMC Scholia
  7. Labib S, Williams A, Yauk CL, Nikota JK, Wallin H, Vogel U, et al. Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes. Part Fibre Toxicol. 2016 Mar 15;13:15. PubMed Europe PMC Scholia
  8. Nymark P, Rieswijk L, Ehrhart F, Jeliazkova N, Tsiliki G, Sarimveis H, et al. A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions. Toxicol Sci. 2018 Mar 1;162(1):264–75. PubMed Europe PMC Scholia