Tyrobp causal network in microglia (WP3625)

The direct and indirect causal inputs upstream and downstream of Tyrobp in microglial cells. Manually translated from human model from Zhang (Cell 2013) to mouse: Gimap2 and Lgals9 (light gray) have no mouse ortholog.
last edited

Authors

Khanspers, AlexanderPico, Egonw, and Eweitz

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: innate immune response pathway Alzheimer's disease pathway

Cell Type Ontology: microglial cell

Participants

Label Type Compact Identifier
Gimap2 GeneProduct None
Tcirg1 GeneProduct ensembl:ENSMUSG00000001750
Dpyd GeneProduct ensembl:ENSMUSG00000033308
Samsn1 GeneProduct ensembl:ENSMUSG00000022876
Il13ra1 GeneProduct ensembl:ENSMUSG00000017057
Gpx1 GeneProduct ensembl:ENSMUSG00000063856
Lgals9c GeneProduct None
Itgam GeneProduct ensembl:ENSMUSG00000030786
Bin2 GeneProduct ensembl:ENSMUSG00000098112
Ppp1r18 GeneProduct ensembl:ENSMUSG00000034595
Igsf6 GeneProduct ensembl:ENSMUSG00000035004
Pycard GeneProduct ensembl:ENSMUSG00000030793
Nckap1l GeneProduct ensembl:ENSMUSG00000022488
Slc1a5 GeneProduct ensembl:ENSMUSG00000001918
Fkbp15 GeneProduct ensembl:ENSMUSG00000066151
Npc2 GeneProduct ensembl:ENSMUSG00000021242
Cxcl16 GeneProduct ensembl:ENSMUSG00000018920
Tyrobp GeneProduct ensembl:ENSMUSG00000030579
Hlx GeneProduct ensembl:ENSMUSG00000039377
Cd4 GeneProduct ensembl:ENSMUSG00000023274
Abcc4 GeneProduct ensembl:ENSMUSG00000032849
Slc7a7 GeneProduct ensembl:ENSMUSG00000000958
Rbm47 GeneProduct ensembl:ENSMUSG00000070780
Apbb1ip GeneProduct ensembl:ENSMUSG00000026786
C1qc GeneProduct ensembl:ENSMUSG00000036896
Itgb2 GeneProduct ensembl:ENSMUSG00000000290
Adap2 GeneProduct ensembl:ENSMUSG00000020709
Tmem106a GeneProduct ensembl:ENSMUSG00000034947
Capg GeneProduct ensembl:ENSMUSG00000056737
Stat5a GeneProduct ensembl:ENSMUSG00000004043
Elf4 GeneProduct ensembl:ENSMUSG00000031103
Rps6ka1 GeneProduct ensembl:ENSMUSG00000003644
Spp1 GeneProduct ensembl:ENSMUSG00000029304
Creb3l2 GeneProduct ensembl:ENSMUSG00000038648
Zfp36l2 GeneProduct ensembl:ENSMUSG00000045817
Runx3 GeneProduct ensembl:ENSMUSG00000070691
Plek GeneProduct ensembl:ENSMUSG00000020120
Nrros GeneProduct ensembl:ENSMUSG00000052384
Lyl1 GeneProduct ensembl:ENSMUSG00000034041
Loxl3 GeneProduct ensembl:ENSMUSG00000000693
C3 GeneProduct ensembl:ENSMUSG00000024164
Ncf2 GeneProduct ensembl:ENSMUSG00000026480
Gapt GeneProduct ensembl:ENSMUSG00000046006
Cd37 GeneProduct ensembl:ENSMUSG00000030798
Tgfbr1 GeneProduct ensembl:ENSMUSG00000007613
Gal3st4 GeneProduct ensembl:ENSMUSG00000075593
Cd84 GeneProduct ensembl:ENSMUSG00000038147
Itgax GeneProduct ensembl:ENSMUSG00000030789
Rnase6 GeneProduct ensembl:ENSMUSG00000021880
Hcls1 GeneProduct ensembl:ENSMUSG00000022831
Il10ra GeneProduct ensembl:ENSMUSG00000032089
Sh2b3 GeneProduct ensembl:ENSMUSG00000042594
Cytl1 GeneProduct ensembl:ENSMUSG00000062329
Tnfrsf1b GeneProduct ensembl:ENSMUSG00000028599
Rgs1 GeneProduct ensembl:ENSMUSG00000026358
Il18 GeneProduct ensembl:ENSMUSG00000039217
Kcne3 GeneProduct ensembl:ENSMUSG00000035165
Sft2d2 GeneProduct ensembl:ENSMUSG00000040848
Maf GeneProduct ensembl:ENSMUSG00000055435
Lhfpl2 GeneProduct ensembl:ENSMUSG00000045312

References

  1. Zhang B, Gaiteri C, Bodea L-G, Wang Z, McElwee J, Podtelezhnikov AA, et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease. Cell. 2013 Apr 25;153(3):707–20. PubMed Europe PMC Scholia
  2. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, et al. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol. 2018 Nov;19(11):1212–23. PubMed Europe PMC Scholia