Microglia pathogen phagocytosis pathway (WP3626)

Pathogens are recognized by complement C1q or immunoglobulin (IgG) that bind to microglia complement receptors (e.g., ITGAM/ITGB2) or Fc-receptors (e.g., FCGR1) that signal via the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor molecules TYROBP or FCER1G, respectively. Alternatively, pathogens are directly recognized by classical innate immune receptors (e.g., TREM2) that require the interaction with TYROBP for further signaling. This pathway was converted from the original human pathway to mouse.
last edited

Authors

Khanspers, AlexanderPico, MaintBot, DeSl, Egonw, and Eweitz

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: innate immune response pathway Alzheimer's disease pathway

Cell Type Ontology: microglial cell

Participants

Label Type Compact Identifier
Oxygen Metabolite hmdb:HMDB0001377
Pik3 GeneProduct None
IgG GeneProduct None
Hck GeneProduct ensembl:ENSMUSG00000003283
C1qa GeneProduct ensembl:ENSMUSG00000036887
Tyrobp GeneProduct ensembl:ENSMUSG00000030579
Syk GeneProduct ensembl:ENSMUSG00000021457
Pik3r1 GeneProduct ensembl:ENSMUSG00000041417
Siglece GeneProduct ensembl:ENSMUSG00000030474
Trem1 GeneProduct ensembl:ENSMUSG00000042265
PIP2 Metabolite wikidata:Q27088398
Fcer1g GeneProduct ensembl:ENSMUSG00000058715
Fcgr1 GeneProduct ensembl:ENSMUSG00000015947
Itgam GeneProduct ensembl:ENSMUSG00000030786
Trem2 GeneProduct ensembl:ENSMUSG00000023992
Trem3 GeneProduct ensembl:ENSMUSG00000041754
Itgb2 GeneProduct ensembl:ENSMUSG00000000290
Lyn GeneProduct ensembl:ENSMUSG00000042228
Ptpn6 GeneProduct ensembl:ENSMUSG00000004266
Plcg2 GeneProduct ensembl:ENSMUSG00000034330
Lat GeneProduct ensembl:ENSMUSG00000030742
Rac1 GeneProduct ensembl:ENSMUSG00000001847
Rac2 GeneProduct ensembl:ENSMUSG00000033220
Rac3 GeneProduct ensembl:ENSMUSG00000018012
Vav1 GeneProduct ensembl:ENSMUSG00000034116
Vav2 GeneProduct ensembl:ENSMUSG00000009621
Vav3 GeneProduct ensembl:ENSMUSG00000033721
Nckap1l GeneProduct ensembl:ENSMUSG00000022488
Arpc1b GeneProduct ensembl:ENSMUSG00000029622
Ncf4 GeneProduct ensembl:ENSMUSG00000071715
Ncf2 GeneProduct ensembl:ENSMUSG00000026480
Ncf1 GeneProduct ensembl:ENSMUSG00000015950
Cybb GeneProduct ensembl:ENSMUSG00000015340
Cyba GeneProduct ensembl:ENSMUSG00000006519
Ncf1 GeneProduct ensembl:ENSMUSG00000015950
Ncf4 GeneProduct ensembl:ENSMUSG00000071715
Ncf2 GeneProduct ensembl:ENSMUSG00000026480
Rac1 GeneProduct ensembl:ENSMUSG00000001847
Rac2 GeneProduct ensembl:ENSMUSG00000033220
Rac3 GeneProduct ensembl:ENSMUSG00000018012
Cybb GeneProduct ensembl:ENSMUSG00000015340
Cyba GeneProduct ensembl:ENSMUSG00000006519
C1qb GeneProduct ensembl:ENSMUSG00000036905
C1qc GeneProduct ensembl:ENSMUSG00000036896
PIP3 Metabolite hmdb:HMDB0004249
Pik3cg GeneProduct ensembl:ENSMUSG00000020573
Pik3ca GeneProduct ensembl:ENSMUSG00000027665
Pik3cd GeneProduct ensembl:ENSMUSG00000039936
Pik3cb GeneProduct ensembl:ENSMUSG00000032462
Pik3r2 GeneProduct ensembl:ENSMUSG00000031834
Pik3c3 GeneProduct ensembl:ENSMUSG00000033628
Pik3c2a GeneProduct ensembl:ENSMUSG00000030660
Pik3r6 GeneProduct ensembl:ENSMUSG00000046207
Pik3r3 GeneProduct ensembl:ENSMUSG00000028698

References

  1. Zhang B, Gaiteri C, Bodea L-G, Wang Z, McElwee J, Podtelezhnikov AA, et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease. Cell. 2013 Apr 25;153(3):707–20. PubMed Europe PMC Scholia